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P70160

- CALC_MOUSE

UniProt

P70160 - CALC_MOUSE

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Protein

Calcitonin

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

  1. calcitonin receptor binding Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. activation of protein kinase activity Source: Ensembl
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  4. aging Source: Ensembl
  5. cellular calcium ion homeostasis Source: MGI
  6. detection of temperature stimulus involved in sensory perception of pain Source: MGI
  7. embryo implantation Source: Ensembl
  8. feeding behavior Source: MGI
  9. inflammatory response Source: MGI
  10. monocyte chemotaxis Source: Ensembl
  11. negative regulation of blood pressure Source: MGI
  12. negative regulation of bone resorption Source: Ensembl
  13. negative regulation of neurological system process Source: MGI
  14. negative regulation of ossification Source: MGI
  15. negative regulation of smooth muscle contraction Source: MGI
  16. negative regulation of transcription, DNA-templated Source: Ensembl
  17. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  18. neuropeptide signaling pathway Source: MGI
  19. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  20. positive regulation of ossification Source: MGI
  21. regulation of heart rate Source: MGI
  22. regulation of inflammatory response Source: Ensembl
  23. response to heat Source: MGI
  24. response to pain Source: MGI
  25. sperm capacitation Source: MGI
  26. vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2151253. Calca.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: MGI
  5. intracellular Source: MGI
  6. neuronal cell body Source: MGI
  7. neuron projection Source: MGI
  8. nucleus Source: Ensembl
  9. terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 8257PRO_0000004056Add
BLAST
Peptidei85 – 11632CalcitoninPRO_0000004057Add
BLAST
Propeptidei121 – 13616PRO_0000004058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 91By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Curated
Modified residuei116 – 1161Proline amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70160.

Expressioni

Gene expression databases

BgeeiP70160.
CleanExiMM_CALCA.
ExpressionAtlasiP70160. baseline and differential.
GenevestigatoriP70160.

Structurei

3D structure databases

ProteinModelPortaliP70160.
SMRiP70160. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP70160.
OMAiEYETENI.
PhylomeDBiP70160.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA
60 70 80 90 100
ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL
110 120 130
NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN
Length:136
Mass (Da):15,141
Last modified:February 1, 1997 - v1
Checksum:iB7F1DD27F7E10DE5
GO
Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q99JA0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):14,065
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081Q → K in AAH30071. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97991 mRNA. Translation: CAA66630.1.
AF325522, AF325521 Genomic DNA. Translation: AAK18180.1.
BC030071 mRNA. Translation: AAH30071.1.
CCDSiCCDS21763.1. [P70160-1]
PIRiJC4977.
RefSeqiNP_031613.2. NM_007587.2. [P70160-1]
XP_006507335.1. XM_006507272.1. [P70160-1]
XP_006507336.1. XM_006507273.1. [P70160-1]
UniGeneiMm.4361.

Genome annotation databases

EnsembliENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669. [P70160-1]
GeneIDi12310.
KEGGimmu:12310.
UCSCiuc009jig.2. mouse. [P70160-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97991 mRNA. Translation: CAA66630.1 .
AF325522 , AF325521 Genomic DNA. Translation: AAK18180.1 .
BC030071 mRNA. Translation: AAH30071.1 .
CCDSi CCDS21763.1. [P70160-1 ]
PIRi JC4977.
RefSeqi NP_031613.2. NM_007587.2. [P70160-1 ]
XP_006507335.1. XM_006507272.1. [P70160-1 ]
XP_006507336.1. XM_006507273.1. [P70160-1 ]
UniGenei Mm.4361.

3D structure databases

ProteinModelPortali P70160.
SMRi P70160. Positions 85-116.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P70160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032907 ; ENSMUSP00000032907 ; ENSMUSG00000030669 . [P70160-1 ]
GeneIDi 12310.
KEGGi mmu:12310.
UCSCi uc009jig.2. mouse. [P70160-1 ]

Organism-specific databases

CTDi 796.
MGIi MGI:2151253. Calca.

Phylogenomic databases

GeneTreei ENSGT00390000010511.
HOGENOMi HOG000038203.
HOVERGENi HBG031362.
InParanoidi P70160.
OMAi EYETENI.
PhylomeDBi P70160.
TreeFami TF333069.

Enzyme and pathway databases

Reactomei REACT_198563. Amyloids.

Miscellaneous databases

ChiTaRSi CALCA. mouse.
NextBioi 280856.
PROi P70160.
SOURCEi Search...

Gene expression databases

Bgeei P70160.
CleanExi MM_CALCA.
ExpressionAtlasi P70160. baseline and differential.
Genevestigatori P70160.

Family and domain databases

InterProi IPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view ]
PANTHERi PTHR10505. PTHR10505. 1 hit.
Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view ]
PRINTSi PR00270. CALCITONINA.
SMARTi SM00113. CALCITONIN. 1 hit.
[Graphical view ]
PROSITEi PS00258. CALCITONIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of mouse procalcitonin."
    Rehli M., Luger K., Beier W., Falk W.
    Biochem. Biophys. Res. Commun. 226:420-425(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  2. "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
    Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
    DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCALC_MOUSE
AccessioniPrimary (citable) accession number: P70160
Secondary accession number(s): Q8K1K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3