P70160 (CALC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcitonin

Gene names

Name:	Calca
Synonyms:	Calc

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calcitonin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of adenylate cyclase activity Inferred from direct assay PubMed 8582325. Source: MGI activation of protein kinase activity Inferred from electronic annotation. Source: Compara adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from genetic interaction PubMed 8582325. Source: MGI aging Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from genetic interaction PubMed 12488435. Source: MGI detection of temperature stimulus involved in sensory perception of pain Inferred from mutant phenotype PubMed 16118273. Source: MGI elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara feeding behavior Inferred from direct assay PubMed 8735980. Source: MGI inflammatory response Inferred from direct assay PubMed 7698182. Source: MGI monocyte chemotaxis Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from mutant phenotype PubMed 10642343PubMed 11717154PubMed 15583078. Source: MGI negative regulation of bone resorption Inferred from electronic annotation. Source: Compara negative regulation of neurological system process Inferred from mutant phenotype PubMed 11717154. Source: MGI negative regulation of ossification Inferred from mutant phenotype PubMed 12488435PubMed 15537449. Source: MGI negative regulation of smooth muscle contraction Inferred from direct assay PubMed 9322931. Source: MGI negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from direct assay PubMed 7698182. Source: MGI positive regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara positive regulation of ossification Inferred from mutant phenotype PubMed 15537449. Source: MGI regulation of heart rate Inferred from mutant phenotype PubMed 11717154. Source: MGI regulation of inflammatory response Inferred from electronic annotation. Source: Compara response to heat Inferred from mutant phenotype PubMed 11166483PubMed 16118273. Source: MGI response to pain Inferred from mutant phenotype PubMed 10208559PubMed 11276224. Source: MGI sperm capacitation Inferred from sequence alignment PubMed 12704735. Source: MGI vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Inferred from mutant phenotype PubMed 11717154. Source: MGI
Cellular_component	axon Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay PubMed 11551509PubMed 14765981PubMed 9271704. Source: MGI extracellular space Inferred from direct assay PubMed 14765981. Source: MGI neuronal cell body Inferred from direct assay PubMed 9838101. Source: MGI nucleus Inferred from electronic annotation. Source: Compara terminal bouton Inferred from direct assay PubMed 10208559PubMed 10532808PubMed 8453761PubMed 9853118. Source: MGI
Molecular_function	calcitonin receptor binding Inferred from direct assay PubMed 9322931. Source: MGI receptor binding Inferred from direct assay PubMed 7698182PubMed 8278635. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Calcitonin (identifier: P70160-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1)

The sequence of this isoform can be found in the external entry Q99JA0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 82	57			PRO_0000004056
	Peptide	85 – 116	32	Calcitonin		PRO_0000004057
	Propeptide	121 – 136	16			PRO_0000004058
Amino acid modifications
	Modified residue	116	1	Proline amide By similarity
	Glycosylation	87	1	N-linked (GlcNAc...) Probable
	Disulfide bond	85 ↔ 91		By similarity
Experimental info
	Sequence conflict	108	1	Q → K in AAH30071. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Calcitonin [UniParc]. Last modified February 1, 1997. Version 1. Checksum: B7F1DD27F7E10DE5	FASTA	136	15,141
	10 20 30 40 50 60 MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK 70 80 90 100 110 120 ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL NKFHTFPQTS IGVEAPGKKR 130 DVAKDLETNH QSHFGN
	Isoform Calcitonin-gene related peptide I [UniParc]. See Q99JA0.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of mouse procalcitonin." Rehli M., Luger K., Beier W., Falk W. Biochem. Biophys. Res. Commun. 226:420-425(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.
[2]	"Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes." Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J. DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97991 mRNA. Translation: CAA66630.1. AF325522, AF325521 Genomic DNA. Translation: AAK18180.1. BC030071 mRNA. Translation: AAH30071.1.
IPI	IPI00377495.
PIR	JC4977.
RefSeq	NP_031613.2. NM_007587.2.
UniGene	Mm.4361.
3D structure databases
ProteinModelPortal	P70160.
SMR	P70160. Positions 85-116.
ModBase	Search...
Proteomic databases
PRIDE	P70160.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669.
GeneID	12310.
KEGG	mmu:12310.
UCSC	uc009jig.2. mouse.
Organism-specific databases
CTD	796.
MGI	MGI:2151253. Calca.
Phylogenomic databases
GeneTree	ENSGT00390000010511.
HOGENOM	HOG000038203.
HOVERGEN	HBG031362.
InParanoid	P70160.
Gene expression databases
ArrayExpress	P70160.
Bgee	P70160.
CleanEx	MM_CALCA.
Genevestigator	P70160.
GermOnline	ENSMUSG00000030669. Mus musculus.
Family and domain databases
InterPro	IPR018360. Calcitonin_CS. IPR001693. Calcitonin_peptide-like. IPR021117. Procalcitonin-like. IPR021116. Procalcitonin/adrenomedullin. IPR021118. Procalcitonin_A-typ. [Graphical view]
PANTHER	PTHR10505. PTHR10505. 1 hit. PTHR10505:SF3. PTHR10505:SF3. 1 hit.
Pfam	PF00214. Calc_CGRP_IAPP. 1 hit. [Graphical view]
PRINTS	PR00270. CALCITONINA.
SMART	SM00113. CALCITONIN. 1 hit. [Graphical view]
PROSITE	PS00258. CALCITONIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CALCA. mouse.
NextBio	280856.
SOURCE	Search...

Entry information

Entry name

CALC_MOUSE

Accession

Primary (citable) accession number: P70160
Secondary accession number(s): Q8K1K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program