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Protein

Calcitonin

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

  • calcitonin receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW
  • identical protein binding Source: Ensembl
  • signaling receptor binding Source: MGI

GO - Biological processi

  • activation of adenylate cyclase activity Source: MGI
  • activation of protein kinase activity Source: Ensembl
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • aging Source: Ensembl
  • artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular response to nerve growth factor stimulus Source: MGI
  • cellular response to tumor necrosis factor Source: Ensembl
  • detection of temperature stimulus involved in sensory perception of pain Source: MGI
  • embryo implantation Source: Ensembl
  • feeding behavior Source: MGI
  • inflammatory response Source: MGI
  • monocyte chemotaxis Source: Ensembl
  • negative regulation of blood pressure Source: MGI
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of neurological system process Source: MGI
  • negative regulation of ossification Source: MGI
  • negative regulation of smooth muscle contraction Source: MGI
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  • neuropeptide signaling pathway Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  • positive regulation of ossification Source: MGI
  • regulation of heart rate Source: MGI
  • response to heat Source: MGI
  • response to pain Source: MGI
  • sperm capacitation Source: MGI

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2151253 Calca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405626 – 82Add BLAST57
PeptideiPRO_000000405785 – 116CalcitoninAdd BLAST32
PropeptideiPRO_0000004058121 – 136Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Disulfide bondi85 ↔ 91By similarity
Glycosylationi87N-linked (GlcNAc...) asparagineCurated1
Modified residuei116Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70160
PRIDEiP70160

PTM databases

PhosphoSitePlusiP70160

Expressioni

Gene expression databases

BgeeiENSMUSG00000030669
CleanExiMM_CALCA
ExpressionAtlasiP70160 baseline and differential
GenevisibleiP70160 MM

Interactioni

GO - Molecular functioni

  • calcitonin receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW
  • identical protein binding Source: Ensembl
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032907

Structurei

3D structure databases

ProteinModelPortaliP70160
SMRiP70160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S Eukaryota
ENOG4111KS6 LUCA
GeneTreeiENSGT00390000010511
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP70160
OrthoDBiEOG091G0RF5
PhylomeDBiP70160
TreeFamiTF333069

Family and domain databases

InterProiView protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00270 CALCITONINA
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA
60 70 80 90 100
ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL
110 120 130
NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN
Length:136
Mass (Da):15,141
Last modified:February 1, 1997 - v1
Checksum:iB7F1DD27F7E10DE5
GO
Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q99JA0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):14,065
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → K in AAH30071 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97991 mRNA Translation: CAA66630.1
AF325522, AF325521 Genomic DNA Translation: AAK18180.1
BC030071 mRNA Translation: AAH30071.1
CCDSiCCDS21763.1 [P70160-1]
PIRiJC4977
RefSeqiNP_001292545.1, NM_001305616.1 [P70160-1]
NP_031613.2, NM_007587.2 [P70160-1]
XP_017177447.1, XM_017321958.1 [P70160-1]
XP_017177448.1, XM_017321959.1 [P70160-1]
XP_017177449.1, XM_017321960.1 [P70160-1]
UniGeneiMm.4361

Genome annotation databases

EnsembliENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669 [P70160-1]
ENSMUST00000206853; ENSMUSP00000146328; ENSMUSG00000030669 [P70160-1]
GeneIDi12310
UCSCiuc009jig.2 mouse [P70160-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALC_MOUSE
AccessioniPrimary (citable) accession number: P70160
Secondary accession number(s): Q8K1K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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