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Protein

Calcitonin

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

  • calcitonin receptor binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • activation of adenylate cyclase activity Source: MGI
  • activation of protein kinase activity Source: Ensembl
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • aging Source: Ensembl
  • cellular calcium ion homeostasis Source: MGI
  • cellular response to nerve growth factor stimulus Source: Ensembl
  • cellular response to tumor necrosis factor Source: Ensembl
  • detection of temperature stimulus involved in sensory perception of pain Source: MGI
  • embryo implantation Source: Ensembl
  • feeding behavior Source: MGI
  • inflammatory response Source: MGI
  • monocyte chemotaxis Source: Ensembl
  • negative regulation of blood pressure Source: MGI
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of neurological system process Source: MGI
  • negative regulation of ossification Source: MGI
  • negative regulation of smooth muscle contraction Source: MGI
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  • neuropeptide signaling pathway Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  • positive regulation of ossification Source: MGI
  • regulation of heart rate Source: MGI
  • regulation of inflammatory response Source: Ensembl
  • regulation of mitochondrion degradation Source: MGI
  • response to heat Source: MGI
  • response to pain Source: MGI
  • sperm capacitation Source: MGI
  • vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2151253. Calca.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • cytoplasm Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • intracellular Source: MGI
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
  • nucleus Source: Ensembl
  • terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 8257PRO_0000004056Add
BLAST
Peptidei85 – 11632CalcitoninPRO_0000004057Add
BLAST
Propeptidei121 – 13616PRO_0000004058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 91By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Curated
Modified residuei116 – 1161Proline amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70160.

Expressioni

Gene expression databases

BgeeiP70160.
CleanExiMM_CALCA.
ExpressionAtlasiP70160. baseline and differential.
GenevestigatoriP70160.

Structurei

3D structure databases

ProteinModelPortaliP70160.
SMRiP70160. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP70160.
PhylomeDBiP70160.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA
60 70 80 90 100
ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL
110 120 130
NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN
Length:136
Mass (Da):15,141
Last modified:February 1, 1997 - v1
Checksum:iB7F1DD27F7E10DE5
GO
Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q99JA0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):14,065
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081Q → K in AAH30071 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97991 mRNA. Translation: CAA66630.1.
AF325522, AF325521 Genomic DNA. Translation: AAK18180.1.
BC030071 mRNA. Translation: AAH30071.1.
CCDSiCCDS21763.1. [P70160-1]
PIRiJC4977.
RefSeqiNP_031613.2. NM_007587.2. [P70160-1]
UniGeneiMm.4361.

Genome annotation databases

EnsembliENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669. [P70160-1]
GeneIDi12310.
KEGGimmu:12310.
UCSCiuc009jig.2. mouse. [P70160-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97991 mRNA. Translation: CAA66630.1.
AF325522, AF325521 Genomic DNA. Translation: AAK18180.1.
BC030071 mRNA. Translation: AAH30071.1.
CCDSiCCDS21763.1. [P70160-1]
PIRiJC4977.
RefSeqiNP_031613.2. NM_007587.2. [P70160-1]
UniGeneiMm.4361.

3D structure databases

ProteinModelPortaliP70160.
SMRiP70160. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP70160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669. [P70160-1]
GeneIDi12310.
KEGGimmu:12310.
UCSCiuc009jig.2. mouse. [P70160-1]

Organism-specific databases

CTDi796.
MGIiMGI:2151253. Calca.

Phylogenomic databases

GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP70160.
PhylomeDBiP70160.
TreeFamiTF333069.

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi280856.
PROiP70160.
SOURCEiSearch...

Gene expression databases

BgeeiP70160.
CleanExiMM_CALCA.
ExpressionAtlasiP70160. baseline and differential.
GenevestigatoriP70160.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of mouse procalcitonin."
    Rehli M., Luger K., Beier W., Falk W.
    Biochem. Biophys. Res. Commun. 226:420-425(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  2. "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
    Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
    DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCALC_MOUSE
AccessioniPrimary (citable) accession number: P70160
Secondary accession number(s): Q8K1K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 27, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.