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P70160

- CALC_MOUSE

UniProt

P70160 - CALC_MOUSE

Protein

Calcitonin

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

    GO - Molecular functioni

    1. calcitonin receptor binding Source: MGI
    2. receptor binding Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. activation of protein kinase activity Source: Ensembl
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    4. aging Source: Ensembl
    5. cellular calcium ion homeostasis Source: MGI
    6. detection of temperature stimulus involved in sensory perception of pain Source: MGI
    7. embryo implantation Source: Ensembl
    8. feeding behavior Source: MGI
    9. inflammatory response Source: MGI
    10. monocyte chemotaxis Source: Ensembl
    11. negative regulation of blood pressure Source: MGI
    12. negative regulation of bone resorption Source: Ensembl
    13. negative regulation of neurological system process Source: MGI
    14. negative regulation of ossification Source: MGI
    15. negative regulation of smooth muscle contraction Source: MGI
    16. negative regulation of transcription, DNA-templated Source: Ensembl
    17. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
    18. neuropeptide signaling pathway Source: MGI
    19. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    20. positive regulation of ossification Source: MGI
    21. regulation of heart rate Source: MGI
    22. regulation of inflammatory response Source: Ensembl
    23. response to heat Source: MGI
    24. response to pain Source: MGI
    25. sperm capacitation Source: MGI
    26. vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin
    Gene namesi
    Name:Calca
    Synonyms:Calc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2151253. Calca.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. cytoplasm Source: MGI
    3. extracellular region Source: MGI
    4. extracellular space Source: MGI
    5. intracellular Source: MGI
    6. neuronal cell body Source: MGI
    7. neuron projection Source: MGI
    8. nucleus Source: Ensembl
    9. terminal bouton Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 8257PRO_0000004056Add
    BLAST
    Peptidei85 – 11632CalcitoninPRO_0000004057Add
    BLAST
    Propeptidei121 – 13616PRO_0000004058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 91By similarity
    Glycosylationi87 – 871N-linked (GlcNAc...)Curated
    Modified residuei116 – 1161Proline amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP70160.

    Expressioni

    Gene expression databases

    ArrayExpressiP70160.
    BgeeiP70160.
    CleanExiMM_CALCA.
    GenevestigatoriP70160.

    Structurei

    3D structure databases

    ProteinModelPortaliP70160.
    SMRiP70160. Positions 85-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcitonin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00390000010511.
    HOGENOMiHOG000038203.
    HOVERGENiHBG031362.
    InParanoidiP70160.
    OMAiEYETENI.
    PhylomeDBiP70160.
    TreeFamiTF333069.

    Family and domain databases

    InterProiIPR021118. Calcitonin.
    IPR018360. Calcitonin_CS.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view]
    PANTHERiPTHR10505. PTHR10505. 1 hit.
    PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view]
    PRINTSiPR00270. CALCITONINA.
    SMARTiSM00113. CALCITONIN. 1 hit.
    [Graphical view]
    PROSITEiPS00258. CALCITONIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA    50
    ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL 100
    NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN 136
    Length:136
    Mass (Da):15,141
    Last modified:February 1, 1997 - v1
    Checksum:iB7F1DD27F7E10DE5
    GO
    Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q99JA0.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:128
    Mass (Da):14,065
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti108 – 1081Q → K in AAH30071. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97991 mRNA. Translation: CAA66630.1.
    AF325522, AF325521 Genomic DNA. Translation: AAK18180.1.
    BC030071 mRNA. Translation: AAH30071.1.
    CCDSiCCDS21763.1. [P70160-1]
    PIRiJC4977.
    RefSeqiNP_031613.2. NM_007587.2. [P70160-1]
    XP_006507335.1. XM_006507272.1. [P70160-1]
    XP_006507336.1. XM_006507273.1. [P70160-1]
    UniGeneiMm.4361.

    Genome annotation databases

    EnsembliENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669. [P70160-1]
    GeneIDi12310.
    KEGGimmu:12310.
    UCSCiuc009jig.2. mouse. [P70160-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97991 mRNA. Translation: CAA66630.1 .
    AF325522 , AF325521 Genomic DNA. Translation: AAK18180.1 .
    BC030071 mRNA. Translation: AAH30071.1 .
    CCDSi CCDS21763.1. [P70160-1 ]
    PIRi JC4977.
    RefSeqi NP_031613.2. NM_007587.2. [P70160-1 ]
    XP_006507335.1. XM_006507272.1. [P70160-1 ]
    XP_006507336.1. XM_006507273.1. [P70160-1 ]
    UniGenei Mm.4361.

    3D structure databases

    ProteinModelPortali P70160.
    SMRi P70160. Positions 85-116.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P70160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032907 ; ENSMUSP00000032907 ; ENSMUSG00000030669 . [P70160-1 ]
    GeneIDi 12310.
    KEGGi mmu:12310.
    UCSCi uc009jig.2. mouse. [P70160-1 ]

    Organism-specific databases

    CTDi 796.
    MGIi MGI:2151253. Calca.

    Phylogenomic databases

    GeneTreei ENSGT00390000010511.
    HOGENOMi HOG000038203.
    HOVERGENi HBG031362.
    InParanoidi P70160.
    OMAi EYETENI.
    PhylomeDBi P70160.
    TreeFami TF333069.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    ChiTaRSi CALCA. mouse.
    NextBioi 280856.
    PROi P70160.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70160.
    Bgeei P70160.
    CleanExi MM_CALCA.
    Genevestigatori P70160.

    Family and domain databases

    InterProi IPR021118. Calcitonin.
    IPR018360. Calcitonin_CS.
    IPR001693. Calcitonin_peptide-like.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view ]
    PANTHERi PTHR10505. PTHR10505. 1 hit.
    Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view ]
    PRINTSi PR00270. CALCITONINA.
    SMARTi SM00113. CALCITONIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00258. CALCITONIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of mouse procalcitonin."
      Rehli M., Luger K., Beier W., Falk W.
      Biochem. Biophys. Res. Commun. 226:420-425(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thyroid.
    2. "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes."
      Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.
      DNA Seq. 12:131-135(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCALC_MOUSE
    AccessioniPrimary (citable) accession number: P70160
    Secondary accession number(s): Q8K1K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3