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P70124

- SPB5_MOUSE

UniProt

P70124 - SPB5_MOUSE

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Protein

Serpin B5

Gene

Serpinb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei340 – 3412Reactive bond homologBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. extracellular matrix organization Source: MGI
  2. morphogenesis of an epithelium Source: MGI
  3. negative regulation of endopeptidase activity Source: RefGenome
  4. prostate gland morphogenesis Source: MGI
  5. regulation of epithelial cell proliferation Source: MGI
  6. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Protein family/group databases

MEROPSiI04.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:Serpinb5
Synonyms:Pi5, Spi5, Spi7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109579. Serpinb5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: InterPro
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Serpin B5PRO_0000032487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP70124.
PaxDbiP70124.
PRIDEiP70124.

PTM databases

PhosphoSiteiP70124.

Expressioni

Gene expression databases

BgeeiP70124.
GenevestigatoriP70124.

Interactioni

Subunit structurei

Interacts with IRF6.By similarity

Protein-protein interaction databases

BioGridi203447. 1 interaction.
STRINGi10090.ENSMUSP00000108350.

Structurei

3D structure databases

ProteinModelPortaliP70124.
SMRiP70124. Positions 1-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP70124.
KOiK10139.
OMAiDGINCKI.
OrthoDBiEOG7327PB.
PhylomeDBiP70124.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70124-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDALRLANSA FAVDLFKQLC ERDPAGNILF SPICLSTSLS LAQVGTKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLVK RLYIDKSLNP
110 120 130 140 150
STEFISSTKR PYAKELETVD FKDKLEETKG QINSSIKELT DGHFEDILSE
160 170 180 190 200
NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRISKT DTKPVQMMNL
210 220 230 240 250
EATFCLGNID DISCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEQQL
260 270 280 290 300
NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES
310 320 330 340 350
TSDFSGMSET KGVSLSNVIH RVCLEITEDG GESIEVPGSR ILQHKDEFNA
360 370
DHPFIYIIRH NKTRNIIFFG KFCSP
Length:375
Mass (Da):42,111
Last modified:February 1, 1997 - v1
Checksum:i5894DD8B9A76F9A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54705 mRNA. Translation: AAB06042.1.
AK136532 mRNA. Translation: BAE23032.1.
AK145220 mRNA. Translation: BAE26308.1.
CH466520 Genomic DNA. Translation: EDL39856.1.
CH466520 Genomic DNA. Translation: EDL39857.1.
BC005434 mRNA. Translation: AAH05434.1.
CCDSiCCDS35684.1.
RefSeqiNP_033283.1. NM_009257.3.
XP_006529353.1. XM_006529290.1.
XP_006529354.1. XM_006529291.1.
UniGeneiMm.268618.

Genome annotation databases

EnsembliENSMUST00000086701; ENSMUSP00000083908; ENSMUSG00000067006.
ENSMUST00000112729; ENSMUSP00000108349; ENSMUSG00000067006.
ENSMUST00000112730; ENSMUSP00000108350; ENSMUSG00000067006.
GeneIDi20724.
KEGGimmu:20724.
UCSCiuc007cha.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54705 mRNA. Translation: AAB06042.1 .
AK136532 mRNA. Translation: BAE23032.1 .
AK145220 mRNA. Translation: BAE26308.1 .
CH466520 Genomic DNA. Translation: EDL39856.1 .
CH466520 Genomic DNA. Translation: EDL39857.1 .
BC005434 mRNA. Translation: AAH05434.1 .
CCDSi CCDS35684.1.
RefSeqi NP_033283.1. NM_009257.3.
XP_006529353.1. XM_006529290.1.
XP_006529354.1. XM_006529291.1.
UniGenei Mm.268618.

3D structure databases

ProteinModelPortali P70124.
SMRi P70124. Positions 1-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203447. 1 interaction.
STRINGi 10090.ENSMUSP00000108350.

Protein family/group databases

MEROPSi I04.980.

PTM databases

PhosphoSitei P70124.

Proteomic databases

MaxQBi P70124.
PaxDbi P70124.
PRIDEi P70124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086701 ; ENSMUSP00000083908 ; ENSMUSG00000067006 .
ENSMUST00000112729 ; ENSMUSP00000108349 ; ENSMUSG00000067006 .
ENSMUST00000112730 ; ENSMUSP00000108350 ; ENSMUSG00000067006 .
GeneIDi 20724.
KEGGi mmu:20724.
UCSCi uc007cha.1. mouse.

Organism-specific databases

CTDi 5268.
MGIi MGI:109579. Serpinb5.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P70124.
KOi K10139.
OMAi DGINCKI.
OrthoDBi EOG7327PB.
PhylomeDBi P70124.
TreeFami TF352619.

Miscellaneous databases

ChiTaRSi Serpinb5. mouse.
NextBioi 299325.
PROi P70124.
SOURCEi Search...

Gene expression databases

Bgeei P70124.
Genevestigatori P70124.

Family and domain databases

InterProi IPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00676. MASPIN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility."
    Zhang M., Sheng S., Maass N., Sager R.
    Mol. Med. 3:49-59(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Mammary gland.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSPB5_MOUSE
AccessioniPrimary (citable) accession number: P70124
Secondary accession number(s): Q3ULZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3