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P70124

- SPB5_MOUSE

UniProt

P70124 - SPB5_MOUSE

Protein

Serpin B5

Gene

Serpinb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei340 – 3412Reactive bond homologBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. extracellular matrix organization Source: MGI
    2. morphogenesis of an epithelium Source: MGI
    3. negative regulation of endopeptidase activity Source: RefGenome
    4. prostate gland morphogenesis Source: MGI
    5. regulation of epithelial cell proliferation Source: MGI
    6. regulation of proteolysis Source: RefGenome

    Protein family/group databases

    MEROPSiI04.980.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B5
    Alternative name(s):
    Maspin
    Peptidase inhibitor 5
    Short name:
    PI-5
    Gene namesi
    Name:Serpinb5
    Synonyms:Pi5, Spi5, Spi7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109579. Serpinb5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Serpin B5PRO_0000032487Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP70124.
    PaxDbiP70124.
    PRIDEiP70124.

    PTM databases

    PhosphoSiteiP70124.

    Expressioni

    Gene expression databases

    BgeeiP70124.
    GenevestigatoriP70124.

    Interactioni

    Subunit structurei

    Interacts with IRF6.By similarity

    Protein-protein interaction databases

    BioGridi203447. 1 interaction.
    STRINGi10090.ENSMUSP00000108350.

    Structurei

    3D structure databases

    ProteinModelPortaliP70124.
    SMRiP70124. Positions 1-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115014.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiQ3ULZ0.
    KOiK10139.
    OMAiDGINCKI.
    OrthoDBiEOG7327PB.
    PhylomeDBiP70124.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00676. MASPIN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70124-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDALRLANSA FAVDLFKQLC ERDPAGNILF SPICLSTSLS LAQVGTKGDT    50
    ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLVK RLYIDKSLNP 100
    STEFISSTKR PYAKELETVD FKDKLEETKG QINSSIKELT DGHFEDILSE 150
    NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRISKT DTKPVQMMNL 200
    EATFCLGNID DISCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEQQL 250
    NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES 300
    TSDFSGMSET KGVSLSNVIH RVCLEITEDG GESIEVPGSR ILQHKDEFNA 350
    DHPFIYIIRH NKTRNIIFFG KFCSP 375
    Length:375
    Mass (Da):42,111
    Last modified:February 1, 1997 - v1
    Checksum:i5894DD8B9A76F9A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U54705 mRNA. Translation: AAB06042.1.
    AK136532 mRNA. Translation: BAE23032.1.
    AK145220 mRNA. Translation: BAE26308.1.
    CH466520 Genomic DNA. Translation: EDL39856.1.
    CH466520 Genomic DNA. Translation: EDL39857.1.
    BC005434 mRNA. Translation: AAH05434.1.
    CCDSiCCDS35684.1.
    RefSeqiNP_033283.1. NM_009257.3.
    XP_006529353.1. XM_006529290.1.
    XP_006529354.1. XM_006529291.1.
    UniGeneiMm.268618.

    Genome annotation databases

    EnsembliENSMUST00000086701; ENSMUSP00000083908; ENSMUSG00000067006.
    ENSMUST00000112729; ENSMUSP00000108349; ENSMUSG00000067006.
    ENSMUST00000112730; ENSMUSP00000108350; ENSMUSG00000067006.
    GeneIDi20724.
    KEGGimmu:20724.
    UCSCiuc007cha.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U54705 mRNA. Translation: AAB06042.1 .
    AK136532 mRNA. Translation: BAE23032.1 .
    AK145220 mRNA. Translation: BAE26308.1 .
    CH466520 Genomic DNA. Translation: EDL39856.1 .
    CH466520 Genomic DNA. Translation: EDL39857.1 .
    BC005434 mRNA. Translation: AAH05434.1 .
    CCDSi CCDS35684.1.
    RefSeqi NP_033283.1. NM_009257.3.
    XP_006529353.1. XM_006529290.1.
    XP_006529354.1. XM_006529291.1.
    UniGenei Mm.268618.

    3D structure databases

    ProteinModelPortali P70124.
    SMRi P70124. Positions 1-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203447. 1 interaction.
    STRINGi 10090.ENSMUSP00000108350.

    Protein family/group databases

    MEROPSi I04.980.

    PTM databases

    PhosphoSitei P70124.

    Proteomic databases

    MaxQBi P70124.
    PaxDbi P70124.
    PRIDEi P70124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086701 ; ENSMUSP00000083908 ; ENSMUSG00000067006 .
    ENSMUST00000112729 ; ENSMUSP00000108349 ; ENSMUSG00000067006 .
    ENSMUST00000112730 ; ENSMUSP00000108350 ; ENSMUSG00000067006 .
    GeneIDi 20724.
    KEGGi mmu:20724.
    UCSCi uc007cha.1. mouse.

    Organism-specific databases

    CTDi 5268.
    MGIi MGI:109579. Serpinb5.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115014.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi Q3ULZ0.
    KOi K10139.
    OMAi DGINCKI.
    OrthoDBi EOG7327PB.
    PhylomeDBi P70124.
    TreeFami TF352619.

    Miscellaneous databases

    NextBioi 299325.
    PROi P70124.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70124.
    Genevestigatori P70124.

    Family and domain databases

    InterProi IPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00676. MASPIN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility."
      Zhang M., Sheng S., Maass N., Sager R.
      Mol. Med. 3:49-59(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum and Mammary gland.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSPB5_MOUSE
    AccessioniPrimary (citable) accession number: P70124
    Secondary accession number(s): Q3ULZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3