Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosome maturation protein SBDS

Gene

Sbds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Protein 22A3
Shwachman-Bodian-Diamond syndrome protein homolog
Gene namesi
Name:Sbds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913961. Sbds.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality. Embryos cease to develop prior to 6.5 dpc. Reduced assembly of 60S ribosomes and accumulation of halfmer ribosomes.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 250249Ribosome maturation protein SBDSPRO_0000123763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei238 – 2381PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70122.
MaxQBiP70122.
PaxDbiP70122.
PRIDEiP70122.

PTM databases

iPTMnetiP70122.
PhosphoSiteiP70122.

Expressioni

Tissue specificityi

Detected in adult liver, brain, heart, spleen, pancreas, kidney, lung and testis (at protein level). Detected in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiP70122.
CleanExiMM_SBDS.
ExpressionAtlasiP70122. baseline and differential.
GenevisibleiP70122. MM.

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211663. 2 interactions.
IntActiP70122. 2 interactions.
MINTiMINT-4133887.
STRINGi10090.ENSMUSP00000026387.

Structurei

3D structure databases

ProteinModelPortaliP70122.
SMRiP70122. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiKOG2917. Eukaryota.
COG1500. LUCA.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiP70122.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiP70122.
TreeFamiTF300881.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Sdo1/SBDS.
[Graphical view]
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKPNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLMKVVESE
210 220 230 240 250
DYSQQLEIVC LIDPGCFREI DELIKKETKG RGSLEVLSLK DVEEGDEKFE
Length:250
Mass (Da):28,781
Last modified:January 23, 2007 - v4
Checksum:i3137CA2807DD250A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005079 mRNA. Translation: BAB23803.1.
AK014648 mRNA. Translation: BAB29487.1.
AK019228 mRNA. Translation: BAB31612.1.
AK168847 mRNA. Translation: BAE40670.1.
BC003849 mRNA. Translation: AAH03849.1.
X99668 mRNA. Translation: CAA67982.1. Sequence problems.
CCDSiCCDS19710.1.
RefSeqiNP_075737.1. NM_023248.2.
UniGeneiMm.280484.

Genome annotation databases

EnsembliENSMUST00000026387; ENSMUSP00000026387; ENSMUSG00000025337.
GeneIDi66711.
KEGGimmu:66711.
UCSCiuc008zuj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005079 mRNA. Translation: BAB23803.1.
AK014648 mRNA. Translation: BAB29487.1.
AK019228 mRNA. Translation: BAB31612.1.
AK168847 mRNA. Translation: BAE40670.1.
BC003849 mRNA. Translation: AAH03849.1.
X99668 mRNA. Translation: CAA67982.1. Sequence problems.
CCDSiCCDS19710.1.
RefSeqiNP_075737.1. NM_023248.2.
UniGeneiMm.280484.

3D structure databases

ProteinModelPortaliP70122.
SMRiP70122. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211663. 2 interactions.
IntActiP70122. 2 interactions.
MINTiMINT-4133887.
STRINGi10090.ENSMUSP00000026387.

PTM databases

iPTMnetiP70122.
PhosphoSiteiP70122.

Proteomic databases

EPDiP70122.
MaxQBiP70122.
PaxDbiP70122.
PRIDEiP70122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026387; ENSMUSP00000026387; ENSMUSG00000025337.
GeneIDi66711.
KEGGimmu:66711.
UCSCiuc008zuj.1. mouse.

Organism-specific databases

CTDi51119.
MGIiMGI:1913961. Sbds.

Phylogenomic databases

eggNOGiKOG2917. Eukaryota.
COG1500. LUCA.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiP70122.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiP70122.
TreeFamiTF300881.

Miscellaneous databases

NextBioi322437.
PROiP70122.
SOURCEiSearch...

Gene expression databases

BgeeiP70122.
CleanExiMM_SBDS.
ExpressionAtlasiP70122. baseline and differential.
GenevisibleiP70122. MM.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Sdo1/SBDS.
[Graphical view]
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryo, Liver and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Crozet F.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE.
    Strain: BALB/cJ.
    Tissue: Cochlea.
  4. "Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality."
    Zhang S., Shi M., Hui C.C., Rommens J.M.
    Mol. Cell. Biol. 26:6656-6663(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  5. "Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses."
    Ball H.L., Zhang B., Riches J.J., Gandhi R., Li J., Rommens J.M., Myers J.S.
    Hum. Mol. Genet. 18:3684-3695(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSBDS_MOUSE
AccessioniPrimary (citable) accession number: P70122
Secondary accession number(s): Q3TG78, Q9CR18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.