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Protein

Galectin-3-binding protein

Gene

LGALS3BP

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Pancreas cancer-associated protein 4
Gene namesi
Name:LGALS3BP
Synonyms:M2BP
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

  • Secreted By similarity
  • Secretedextracellular spaceextracellular matrix By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 578560Galectin-3-binding proteinPRO_0000357034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 113PROSITE-ProRule annotation
Disulfide bondi62 ↔ 123PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi93 ↔ 103PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP70117.
SMRiP70117. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101SRCRPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 22169BTBPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 360101BACKAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052323.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLWLFSLW LLVPGTQGTK DGDMRLVNGA SANEGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWNILDANV VCRALGYENA TQALGRAAFG PGRGPVMLDE VECTGTEPSL
110 120 130 140 150
ANCSSLGWLK SRCGHEKDAG VVCSNETGGV HILDLSGDLP NALGQIFDSQ
160 170 180 190 200
QGCDLFIQVT GQGHGDLTIC AHKLILNTNP EAQALWQVVG SSVIMRVDAE
210 220 230 240 250
CMPVVRDFLR YFYSRRIEVT MSSVKCLHKL ASAYGATQLQ DYCGRLFATL
260 270 280 290 300
LPQDPTFRTP LELYAYAQAT RDSVLEDLCV QFLAWNFEPL TQAEAWLSVP
310 320 330 340 350
TALLQALLSK SDLAVSSELD LLKAVDQWSM ESSASHAEVE RLLEQVRFPM
360 370 380 390 400
VLPQELFELQ FNLSLYEGHR ELFQRKTMEA LEFHTVPFRV LAKYRGLNLT
410 420 430 440 450
EDTYQPRLYT SSTWSTLVTE SSSRSRAAVQ VYGYAQYYPY GYDSRRWYYP
460 470 480 490 500
YQSFQTPQHP SFLFVDKLIS WSATYLPTVQ SCWNYGFSCT PEELPVLGLT
510 520 530 540 550
KSSYSEPAIG YENKALMLCG GYSVVDVANF AGSKAPIPSA LDTNSSKISS
560 570
LFPCSSGAFS GFRVVIRPFY LTNSTDLD
Length:578
Mass (Da):64,399
Last modified:February 1, 1997 - v1
Checksum:i45BF22796BE79EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73375 mRNA. Translation: AAB18745.1.
RefSeqiNP_001268610.1. NM_001281681.1.

Genome annotation databases

GeneIDi101825995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73375 mRNA. Translation: AAB18745.1.
RefSeqiNP_001268610.1. NM_001281681.1.

3D structure databases

ProteinModelPortaliP70117.
SMRiP70117. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101825995.

Organism-specific databases

CTDi3959.

Phylogenomic databases

HOVERGENiHBG052323.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of blood group A-modified glycoproteins in hamster pancreatic cancer and cloning of hamster Mac-2-BP."
    Schaffert C., Pour P.M., MacDonald R.G., Chaney W.G.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLG3BP_MESAU
AccessioniPrimary (citable) accession number: P70117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.