Steroidogenic acute regulatory protein, mitochondrial precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name=StAR

Alternative name(s):
START domain-containing protein 1
Short name=StARD1

Gene names

Name:

STAR

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone By similarity.
Pathway	Steroid metabolism; cholesterol metabolism.
Subunit structure	May interact with TSPO By similarity.
Subcellular location	Mitochondrion.
Sequence similarities	Contains 1 START domain.

Ontologies

Keywords
Biological process	Lipid transport Steroidogenesis Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cholesterol transport Inferred from electronic annotation. Source: GOC steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cholesterol binding Inferred from electronic annotation. Source: InterPro cholesterol transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 62

62

Mitochondrion By similarity

Chain

63 – 284

222

Steroidogenic acute regulatory protein, mitochondrial

PRO_0000033317

Regions

Domain

66 – 279

214

START

Amino acid modifications

Modified residue

56

1

Phosphoserine; by PKA By similarity

Modified residue

194

1

Phosphoserine; by PKA By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P70114 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F238151F9EC8512B
Show »

FASTA

284

31,497

        10         20         30         40         50         60 
MLLATFKLCA GSSYRHLRNM KGLRHQAVLA IGQELNRRTL GDSSPGWISQ VRRRSSLLGS 

        70         80         90        100        110        120 
QLEAALYSEQ ELSYIQQGEV AMQKALSILS NQEGWKKENQ QENGDEVLSK VVPDVGKVFR 

       130        140        150        160        170        180 
LEVVVDQPMD RLYAELVDRM EAMGEWNPNV KEIKVLQKIG KDTVITHELA AAAAGNLVGP 

       190        200        210        220        230        240 
RDFVSVRCAK RRGSTCVLAG IATHFGEMPE QSGVIRAEQG PTCMVLHPLA GSPSKTKFTW 

       250        260        270        280 
LLSIDLKGWL PKSIINQVLS QTQMEFANHL RKRLESSSAS EARC

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References

[1]

"Adrenocorticotropin regulates the level of the steroidogenic acute regulatory (StAR) protein mRNA in hamster adrenals."
Fleury A., Cloutier M., Ducharme L., Lefebvre A., LeHoux J., Lehoux J.-G.
Endocr. Res. 22:515-520(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U66490 mRNA. Translation: AAB06763.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ILJ	model	-	A	66-279	[»]

ProteinModelPortal

P70114.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG010529.

Enzyme and pathway databases

UniPathway

UPA00296.

Family and domain databases

Gene3D

3.30.530.20. 1 hit.

InterPro

IPR000799. StAR.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]

Pfam

PF01852. START. 1 hit.
[Graphical view]

PRINTS

PR00978. STARPROTEIN.

SMART

SM00234. START. 1 hit.
[Graphical view]

PROSITE

PS50848. START. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

STAR_MESAU

Accession

Primary (citable) accession number: P70114

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families