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Protein

Histone H2A.Z-like

Gene

h2a.zl1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.Z-like
Short name:
H2A.Zl
Alternative name(s):
H2A.Z1
XH2AZ
Gene namesi
Name:h2a.zl1
Synonyms:h2a.zl2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256368. h2afz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 128127Histone H2A.Z-likePRO_0000239072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51N6-acetyllysineBy similarity
Modified residuei8 – 81N6-acetyllysineBy similarity
Modified residuei12 – 121N6-acetyllysineBy similarity
Cross-linki122 – 122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP70094.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Expression is highest at the gastrula stage. Expressed preferentially in tissues of mesoderm origin, such as the notochord and some regions of the primitive ear.2 Publications

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Zl forms a heterodimer with H2B (By similarity).By similarity

Protein-protein interaction databases

BioGridi97458. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70094.
SMRiP70094. Positions 17-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

HOVERGENiHBG009342.
KOiK11251.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGKAGKDT GKAKATSITR SSRAGLQFPV GRIHRLLKNR TTSHGRVGGT
60 70 80 90 100
AAVYTAAILE YLTAEVLELA GNASKDLKVK RISPRHLQLA IRGDEELDAL
110 120
IKATIAGGGV IPHIHKSLIG KKGQQKTV
Length:128
Mass (Da):13,486
Last modified:January 23, 2007 - v3
Checksum:i18433898EB6E95AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98535 mRNA. Translation: CAA67148.1.
X98536 mRNA. Translation: CAA67149.1.
U77893 mRNA. Translation: AAB36781.1.
BC044011 mRNA. Translation: AAH44011.1.
BC091714 mRNA. Translation: AAH91714.1.
RefSeqiNP_001079528.1. NM_001086059.1.
NP_001081609.1. NM_001088140.1.
UniGeneiXl.38014.
Xl.42570.

Genome annotation databases

GeneIDi379215.
397949.
KEGGixla:379215.
xla:397949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98535 mRNA. Translation: CAA67148.1.
X98536 mRNA. Translation: CAA67149.1.
U77893 mRNA. Translation: AAB36781.1.
BC044011 mRNA. Translation: AAH44011.1.
BC091714 mRNA. Translation: AAH91714.1.
RefSeqiNP_001079528.1. NM_001086059.1.
NP_001081609.1. NM_001088140.1.
UniGeneiXl.38014.
Xl.42570.

3D structure databases

ProteinModelPortaliP70094.
SMRiP70094. Positions 17-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi97458. 1 interaction.

Proteomic databases

PRIDEiP70094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379215.
397949.
KEGGixla:379215.
xla:397949.

Organism-specific databases

CTDi3015.
XenbaseiXB-GENE-6256368. h2afz.

Phylogenomic databases

HOVERGENiHBG009342.
KOiK11251.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "H2A.Zl, a new variant histone expressed during Xenopus early developement exhibits several distinct features from the core histone H2A."
    Iouzalen N., Moreau J., Mechali M.
    Nucleic Acids Res. 24:3947-3952(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Oocyte.
  2. "Histone H2A.z displays a neural-specific expression pattern in Xenopus."
    Aberger F., Grunz H., Richter K.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg and Embryo.
  4. "Unique residues on the H2A.Z containing nucleosome surface are important for Xenopus laevis development."
    Ridgway P., Brown K.D., Rangasamy D., Svensson U., Tremethick D.J.
    J. Biol. Chem. 279:43815-43820(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiH2AZL_XENLA
AccessioniPrimary (citable) accession number: P70094
Secondary accession number(s): O13272, O13273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.