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P70091

- CP19A_ORENI

UniProt

P70091 - CP19A_ORENI

Protein

Aromatase

Gene

cyp19a1

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:cyp19a1
    Synonyms:cyp19
    OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
    Taxonomic identifieri8128 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
    ProteomesiUP000005207: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522AromatasePRO_0000051971Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP70091.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLISACEQA MNPVGLDAVV ARSLCDLKCH PIDGISMATR TLILLVCLLL    50
    VAWSHTDKKI VPGPSFCLGL GPLLSYLRFI WTGIGTASNY YNNKYGDIVR 100
    VWINGEETLI LSRSSAVHHV LKNGNYTSRF GSIQGLSYLG MNERGIIFNN 150
    NVTLWKKIRT YFAKALTGPN LQQTVDVCVS SIQAHLDHLD SLGHVDVLNL 200
    LRCTVLDISN RLFLNVPLNE KELMLKIQKY FHTWQDVLIK PDIYFKFRWI 250
    HHRHKTATQE LQDAIKRLVD QKRKNMEQAD KLDNINFTAE LIFAQNHGEL 300
    SAENVTQCVL EMVIAAPDTL SLSLFFMLLL LKQNPHVEPQ LLQEIDAVVG 350
    ERQLQNQDLH KLQVMESFIY ECLSFHPVVD FTMRRALSDD IIEGYRISKG 400
    TNIILNTGRM HRTEFFLKGN QFNLEHFENN VPRPPTFQPF GSGPRACIGK 450
    HMAMVMMKSI LVTLLSQYSV CTHEGPILDC LPQTNNLSQQ PVEHQQAETE 500
    HLHMRFLPRQ GSSCQTLKDP NL 522
    Length:522
    Mass (Da):59,428
    Last modified:February 1, 1997 - v1
    Checksum:iEA62E690CF8C06F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72071 mRNA. Translation: AAB16814.1.
    RefSeqiNP_001266515.1. NM_001279586.1.
    UniGeneiOni.44896.

    Genome annotation databases

    GeneIDi100708217.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72071 mRNA. Translation: AAB16814.1 .
    RefSeqi NP_001266515.1. NM_001279586.1.
    UniGenei Oni.44896.

    3D structure databases

    ProteinModelPortali P70091.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100708217.

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the cDNA encoding the tilapia (Oreochromis niloticus) cytochrome P450 aromatase (P450arom): changes in P450arom mRNA, protein and enzyme activity in ovarian follicles during oogenesis."
      Chang X.T., Kobayashi T., Kajiura H., Nakamura M., Nagahama Y.
      J. Mol. Endocrinol. 18:57-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_ORENI
    AccessioniPrimary (citable) accession number: P70091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3