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P70091 (CP19A_ORENI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:cyp19a1
Synonyms:cyp19
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica) [Reference proteome]
Taxonomic identifier8128 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Aromatase
PRO_0000051971

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P70091 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EA62E690CF8C06F6

FASTA52259,428
        10         20         30         40         50         60 
MDLISACEQA MNPVGLDAVV ARSLCDLKCH PIDGISMATR TLILLVCLLL VAWSHTDKKI 

        70         80         90        100        110        120 
VPGPSFCLGL GPLLSYLRFI WTGIGTASNY YNNKYGDIVR VWINGEETLI LSRSSAVHHV 

       130        140        150        160        170        180 
LKNGNYTSRF GSIQGLSYLG MNERGIIFNN NVTLWKKIRT YFAKALTGPN LQQTVDVCVS 

       190        200        210        220        230        240 
SIQAHLDHLD SLGHVDVLNL LRCTVLDISN RLFLNVPLNE KELMLKIQKY FHTWQDVLIK 

       250        260        270        280        290        300 
PDIYFKFRWI HHRHKTATQE LQDAIKRLVD QKRKNMEQAD KLDNINFTAE LIFAQNHGEL 

       310        320        330        340        350        360 
SAENVTQCVL EMVIAAPDTL SLSLFFMLLL LKQNPHVEPQ LLQEIDAVVG ERQLQNQDLH 

       370        380        390        400        410        420 
KLQVMESFIY ECLSFHPVVD FTMRRALSDD IIEGYRISKG TNIILNTGRM HRTEFFLKGN 

       430        440        450        460        470        480 
QFNLEHFENN VPRPPTFQPF GSGPRACIGK HMAMVMMKSI LVTLLSQYSV CTHEGPILDC 

       490        500        510        520 
LPQTNNLSQQ PVEHQQAETE HLHMRFLPRQ GSSCQTLKDP NL 

« Hide

References

[1]"Isolation and characterization of the cDNA encoding the tilapia (Oreochromis niloticus) cytochrome P450 aromatase (P450arom): changes in P450arom mRNA, protein and enzyme activity in ovarian follicles during oogenesis."
Chang X.T., Kobayashi T., Kajiura H., Nakamura M., Nagahama Y.
J. Mol. Endocrinol. 18:57-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72071 mRNA. Translation: AAB16814.1.
RefSeqNP_001266515.1. NM_001279586.1.
UniGeneOni.44896.

3D structure databases

ProteinModelPortalP70091.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100708217.

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_ORENI
AccessionPrimary (citable) accession number: P70091
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families