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P70085

- CP17A_ORYLA

UniProt

P70085 - CP17A_ORYLA

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

cyp17a1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi451 – 4511Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:cyp17a1
Synonyms:cyp17
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051946Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000023959.

Structurei

3D structure databases

ProteinModelPortaliP70085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP70085.
KOiK00512.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform C17L (identifier: P70085-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWFLCLSVL VVLVLALAAL LWRVRTRDRP QEAPSLPYLP VLGSLLSLRS
60 70 80 90 100
PHPPHVLFKE LQQKYGQTYS LKMGSHQVII VNHHAHAREV LLKRGRTFAG
110 120 130 140 150
RPRTVTTDVL TRDGKDIAFG DYSATWRFHR KIVHGALCMF GEGSASLQRI
160 170 180 190 200
ICTEAQSLCS TLSEAAATGL ALDLSPELTR AVTNVICSLC FNSSYSRGDP
210 220 230 240 250
EFEAMLRYSQ GIVDTVAKDS LVDIFPWLQI FPNKDLRLLK QCVAVRDQLL
260 270 280 290 300
QKKFEEHKSD YSDHVQRDLL DALLRAKRSA ENNNTAAEFS AEAVGLSDDH
310 320 330 340 350
LLMTVGDIFG AGVETTTTVL KWAITYLIHY PEVQKQIQEE LDRKVGVDRP
360 370 380 390 400
PQLSDRGSLP FLEATIREVL RIRPVAPLLI PHVALSDTSL GDFTVRKGTR
410 420 430 440 450
VVINLWSLHH DEKEWTNPDL FNPGRFLSAD GSSLTLPSSS YLPFGAGLRV
460 470 480 490 500
CLGEALAKME LFLFLSWILQ RFTLSVPPSQ SLPSLEGKFG VVLQPVKYAV
510
KATPRPGCHS GLFPANP
Length:517
Mass (Da):57,524
Last modified:February 1, 1997 - v1
Checksum:i7A67509437ED6C6E
GO
Isoform C17S (identifier: P70085-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-258: Missing.

Show »
Length:488
Mass (Da):54,004
Checksum:i640239B9AB8B624B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei230 – 25829Missing in isoform C17S. 1 PublicationVSP_000615Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87121 mRNA. Translation: BAA13252.1.
D87122 mRNA. Translation: BAA13253.1.
RefSeqiNP_001098564.1. NM_001105094.1. [P70085-1]
UniGeneiOla.85.

Genome annotation databases

EnsembliENSORLT00000023962; ENSORLP00000023961; ENSORLG00000019226. [P70085-2]
GeneIDi100125816.
KEGGiola:100125816.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87121 mRNA. Translation: BAA13252.1 .
D87122 mRNA. Translation: BAA13253.1 .
RefSeqi NP_001098564.1. NM_001105094.1. [P70085-1 ]
UniGenei Ola.85.

3D structure databases

ProteinModelPortali P70085.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8090.ENSORLP00000023959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSORLT00000023962 ; ENSORLP00000023961 ; ENSORLG00000019226 . [P70085-2 ]
GeneIDi 100125816.
KEGGi ola:100125816.

Organism-specific databases

CTDi 100313515.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P70085.
KOi K00512.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase."
    Fukada S., Tanaka M., Matsuyama M., Kobayashi D., Nagahama Y.
    Mol. Reprod. Dev. 45:285-290(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C17L AND C17S).
    Strain: Orange-red.
    Tissue: Ovarian follicle.

Entry informationi

Entry nameiCP17A_ORYLA
AccessioniPrimary (citable) accession number: P70085
Secondary accession number(s): P70086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3