Reviewed,
UniProtKB/Swiss-Prot P70080 (TPH1_CHICK)
Last modified
November 25, 2008.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tryptophan 5-hydroxylase 1 EC=1.14.16.4 Alternative name(s): Tryptophan 5-monooxygenase 1 | ||||
| Gene names |
| ||||
| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin. |
| Cofactor | Fe(2+) ion. |
| Pathway | Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. |
| Subunit structure | Multimer of identical subunits By similarity. |
| Sequence similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Contains 1 ACT domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Serotonin biosynthesis |
| Ligand | Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW serotonin biosynthetic process from tryptophanInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amino acid binding Inferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: InterPro tryptophan 5-monooxygenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Tryptophan 5-hydroxylase 1 | PRO_0000205572 | |||||
Regions | |||||||||
| Domain | 18 – 92 | 75 | ACT | ||||||
Sites | |||||||||
| Metal binding | 273 | 1 | Iron By similarity | ||||||
| Metal binding | 278 | 1 | Iron By similarity | ||||||
| Metal binding | 318 | 1 | Iron By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 58 | 1 | Phosphoserine; by PKA Potential | ||||||
Sequences
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References
| [1] | "Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels." Florez J.C., Seidenman K.J., Barrett R.K., Sangoram A.M., Takahashi J.S. Brain Res. Mol. Brain Res. 42:25-30(1996) [PubMed: 8915576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: White leghorn. Tissue: Pineal gland. |
Cross-references
Sequence databases | |
|---|---|
| U26428 mRNA. Translation: AAC60036.1. | |
| RefSeq | NP_990287.1. |
| UniGene | Gga.43354 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MLW based on UniProtKB P17752. |
| SMR | P70080. Positions 105-394. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSGALG00000006236. Gallus gallus. [Contig view] |
| GeneID | 395799. |
| KEGG | gga:395799. |
Phylogenomic databases | |
| HOGENOM | P70080. |
| HOVERGEN | P70080. |
Family and domain databases | |
| InterPro | IPR001273. Aaa_hydroxylase. IPR002912. ACT_bd. IPR005963. Tyr_5_mOase. [Graphical view] |
| Gene3D | G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit. |
| PANTHER | PTHR11473. Aaa_hydroxylase. 1 hit. |
| Pfam | PF01842. ACT. 1 hit. PF00351. Biopterin_H. 1 hit. [Graphical view] |
| PRINTS | PR00372. FYWHYDRXLASE. |
| ProDom | PD002559. Aaa_hydroxylase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01270. Trp_5_monoox. 1 hit. |
| PROSITE | PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TPH1_CHICK | ||||||||
| Accession | Primary (citable) accession number: P70080 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


