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Protein

Homeobox protein Nkx-3.2

Gene

nkx3-2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi202 – 261HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-3.2
Alternative name(s):
Bagpipe homeobox protein homolog 1
Xbap
Gene namesi
Name:nkx3-2
Synonyms:bap1 Publication, bapx1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-876836. nkx3-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002718911 – 329Homeobox protein Nkx-3.2Add BLAST329

Expressioni

Tissue specificityi

First expressed in developing facial cartilage in early tailbud embryos, with expression localized to the basihyobranchial, palatoquadrate and possibly Meckel's cartilages. Shortly after, a second area of expression is seen in the musculature of the anterior gut. During late embryogenesis, gut expression extends into hindgut tissues. In adults, expressed at a high level in the kidney, pancreas, spleen and stomach and at a slightly lower level in the intestine, skeletal muscle and tongue. Adult heart, liver and lung show little or no expression.2 Publications

Developmental stagei

First expressed during late neurula stage (stage 18). Levels increase slowly up to the tailbud stage (stage 28), then increase sharply before remaining approximately constant through the remaining tailbud and tadpole stages (stages 30-44).1 Publication

Inductioni

By foxf1-B.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP70061.
SMRiP70061.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-3 homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG006689.
KOiK09995.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P70061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGPLDTPW AADVSPSGPR GIKAGRSALL VPILGSIWGA WRPEPGATRY
60 70 80 90 100
RTLDPMAAVR SSSRLTPFSI QAILNRKEER AHTFPRLATA VSPACCWRIF
110 120 130 140 150
GESEAEGLGS PCGGAPGAGA GGEPSGWDSD SALSEEGELG RPGDIGERKK
160 170 180 190 200
QRPLEARAKG EDEEETPGCS DCEIGASVPD PSPPDEDPKC EQLMLEPPKQ
210 220 230 240 250
RKKRSRAAFS HAQVFELERR FNHQRYLSGP ERADLAASLK LTETQVKIWF
260 270 280 290 300
QNRRYKTKRR QMATDLLAAA PAAKKVAVKV LVRDDQRQYH PGEVLHPSLL
310 320
PLQAPYFYPY YCALPGWTLS AAACSRGTP
Length:329
Mass (Da):36,000
Last modified:February 1, 1997 - v1
Checksum:i8F53AE997C91EE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75487 mRNA. Translation: AAB82336.1.
RefSeqiNP_001079282.1. NM_001085813.1.
UniGeneiXl.226.

Genome annotation databases

GeneIDi378569.
KEGGixla:378569.

Similar proteinsi

Entry informationi

Entry nameiNKX32_XENLA
AccessioniPrimary (citable) accession number: P70061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families