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Protein

Homeobox protein Nkx-3.2

Gene

nkx3-2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi202 – 26160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-3.2
Alternative name(s):
Bagpipe homeobox protein homolog 1
Xbap
Gene namesi
Name:nkx3-2
Synonyms:bap1 Publication, bapx1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-876836. nkx3-2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Homeobox protein Nkx-3.2PRO_0000271891Add
BLAST

Expressioni

Tissue specificityi

First expressed in developing facial cartilage in early tailbud embryos, with expression localized to the basihyobranchial, palatoquadrate and possibly Meckel's cartilages. Shortly after, a second area of expression is seen in the musculature of the anterior gut. During late embryogenesis, gut expression extends into hindgut tissues. In adults, expressed at a high level in the kidney, pancreas, spleen and stomach and at a slightly lower level in the intestine, skeletal muscle and tongue. Adult heart, liver and lung show little or no expression.2 Publications

Developmental stagei

First expressed during late neurula stage (stage 18). Levels increase slowly up to the tailbud stage (stage 28), then increase sharply before remaining approximately constant through the remaining tailbud and tadpole stages (stages 30-44).1 Publication

Inductioni

By foxf1-B.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP70061.
SMRiP70061. Positions 201-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-3 homeobox family.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG006689.
KOiK09995.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGPLDTPW AADVSPSGPR GIKAGRSALL VPILGSIWGA WRPEPGATRY
60 70 80 90 100
RTLDPMAAVR SSSRLTPFSI QAILNRKEER AHTFPRLATA VSPACCWRIF
110 120 130 140 150
GESEAEGLGS PCGGAPGAGA GGEPSGWDSD SALSEEGELG RPGDIGERKK
160 170 180 190 200
QRPLEARAKG EDEEETPGCS DCEIGASVPD PSPPDEDPKC EQLMLEPPKQ
210 220 230 240 250
RKKRSRAAFS HAQVFELERR FNHQRYLSGP ERADLAASLK LTETQVKIWF
260 270 280 290 300
QNRRYKTKRR QMATDLLAAA PAAKKVAVKV LVRDDQRQYH PGEVLHPSLL
310 320
PLQAPYFYPY YCALPGWTLS AAACSRGTP
Length:329
Mass (Da):36,000
Last modified:February 1, 1997 - v1
Checksum:i8F53AE997C91EE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75487 mRNA. Translation: AAB82336.1.
RefSeqiNP_001079282.1. NM_001085813.1.
UniGeneiXl.226.

Genome annotation databases

GeneIDi378569.
KEGGixla:378569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75487 mRNA. Translation: AAB82336.1.
RefSeqiNP_001079282.1. NM_001085813.1.
UniGeneiXl.226.

3D structure databases

ProteinModelPortaliP70061.
SMRiP70061. Positions 201-261.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378569.
KEGGixla:378569.

Organism-specific databases

CTDi579.
XenbaseiXB-GENE-876836. nkx3-2.

Phylogenomic databases

HOVERGENiHBG006689.
KOiK09995.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle."
    Newman C.S., Grow M.W., Cleaver O., Chia F., Krieg P.
    Dev. Biol. 181:223-233(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic head1 Publication.
  2. "Function and regulation of FoxF1 during Xenopus gut development."
    Tseng H.-T., Shah R., Jamrich M.
    Development 131:3637-3647(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiNKX32_XENLA
AccessioniPrimary (citable) accession number: P70061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.