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P70059

- TRY2_XENLA

UniProt

P70059 - TRY2_XENLA

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Protein

Trypsin

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Charge relay systemBy similarity
Metal bindingi73 – 731CalciumBy similarity
Metal bindingi75 – 751Calcium; via carbonyl oxygenBy similarity
Metal bindingi83 – 831CalciumBy similarity
Active sitei105 – 1051Charge relay systemBy similarity
Sitei192 – 1921Required for specificityBy similarity
Active sitei198 – 1981Charge relay systemBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.126.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin (EC:3.4.21.4)
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5776767. prss1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Propeptidei16 – 216Activation peptideBy similarityPRO_0000028235
Chaini22 – 244223TrypsinPRO_0000028236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 158PROSITE-ProRule annotation
Disulfide bondi46 ↔ 62PROSITE-ProRule annotation
Disulfide bondi130 ↔ 231PROSITE-ProRule annotation
Disulfide bondi137 ↔ 204PROSITE-ProRule annotation
Disulfide bondi169 ↔ 183PROSITE-ProRule annotation
Disulfide bondi194 ↔ 218PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP70059.
SMRiP70059. Positions 22-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 242221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70059-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLVILVLL GAAVAFEDDD KIVGGFTCAK NAVPYQVSLN AGYHFCGGSL
60 70 80 90 100
INSQWVVSAA HCYKSRIQVR LGEHNIALNE GTEQFIDSQK VIKHPNYNSR
110 120 130 140 150
NLDNDIMLIK LSTTARLSAN IQSVPLPSAC ASAGTNCLIS GWGNTLSSGT
160 170 180 190 200
NYPDLLQCLN APILTDSQCS NSYPGEITKN MFCAGFLAGG KDSCQGDSGG
210 220 230 240
PVVCNGQLQG VVSWGYGCAQ RNYPGVYTKV CNFVTWIQST ISSN
Length:244
Mass (Da):26,080
Last modified:February 1, 1997 - v1
Checksum:iC63F29CB3300B323
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72330 mRNA. Translation: AAB17274.1.
UniGeneiXl.1858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72330 mRNA. Translation: AAB17274.1 .
UniGenei Xl.1858.

3D structure databases

ProteinModelPortali P70059.
SMRi P70059. Positions 22-244.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-5776767. prss1.

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Wang K., Lytle L., Gan L., Hood L.E.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRY2_XENLA
AccessioniPrimary (citable) accession number: P70059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3