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Protein

Nuclear receptor subfamily 2 group E member 1

Gene

nr2e1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 90Nuclear receptorPROSITE-ProRule annotationAdd BLAST78
Zinc fingeri16 – 36NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri52 – 78NR C4-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group E member 1
Alternative name(s):
Nuclear receptor TLX
Protein tailless homolog
Short name:
Tll
Short name:
xTLL
Gene namesi
Name:nr2e1
Synonyms:tll, tlx
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864991. nr2e1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535961 – 386Nuclear receptor subfamily 2 group E member 1Add BLAST386

Expressioni

Tissue specificityi

Prominent expression in the embryonal optic stalk and the distal tip of the forming vesicle. In tadpole-stage embryos predominantly found in the ciliary margin of the optic cup.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP70052.
SMRiP70052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 355Ligand-bindingBy similarityAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi344 – 348Poly-Leu5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 36NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri52 – 78NR C4-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG005606.
KOiK08545.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P70052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPTGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRSY
60 70 80 90 100
VCKSGNQGGC PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR
110 120 130 140 150
KQVALYFRGH KEVNGSTQHF SSTALPTPTF FTTVRQLEAH NLELAAISTV
160 170 180 190 200
PERQTLVGLA QPTPKYPHEV NGAPLYLYEF ATESVCESAA RLLFMSIKWA
210 220 230 240 250
KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAS TLLAVSGMNN
260 270 280 290 300
ENTESPKLNK IISEIQALQD VVSRFRQLRL DATEFACLKC IVTFKAGVST
310 320 330 340 350
HSGSELRNFR NAAAISALQD EAQLTLNSYI HTRYPTQPCR FGKLLLLLPA
360 370 380
LRSINPSTIE EVFFKKTIGN VPITRVLSDM YKSSDI
Length:386
Mass (Da):42,974
Last modified:February 1, 1997 - v1
Checksum:i0ACE0922F3668172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67886 mRNA. Translation: AAB07732.1.
RefSeqiNP_001079280.1. NM_001085811.1.
UniGeneiXl.1067.

Genome annotation databases

GeneIDi378567.
KEGGixla:378567.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNR2E1_XENLA
AccessioniPrimary (citable) accession number: P70052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: May 10, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families