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Protein

Adenomatous polyposis coli homolog

Gene

apc

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Adenomatous polyposis coli homolog
Short name:
Protein APC
Gene namesi
Name:apc
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-480859. apc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28292829Adenomatous polyposis coli homologPRO_0000064630Add
BLAST

Proteomic databases

PRIDEiP70039.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASAP1Q9ULH15EBI-8069633,EBI-346622From a different organism.
ASAP2O431504EBI-8069633,EBI-310968From a different organism.
AXIN1O151692EBI-8069633,EBI-710484From a different organism.
axin1Q9YGY02EBI-8069633,EBI-1037449

GO - Molecular functioni

Protein-protein interaction databases

BioGridi100780. 2 interactions.
IntActiP70039. 10 interactions.
MINTiMINT-7305229.

Structurei

3D structure databases

ProteinModelPortaliP70039.
SMRiP70039. Positions 2-55, 130-238, 1489-1532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati343 – 38442ARM 1Add
BLAST
Repeati462 – 50443ARM 2Add
BLAST
Repeati516 – 55540ARM 3Add
BLAST
Repeati559 – 59941ARM 4Add
BLAST
Repeati603 – 64644ARM 5Add
BLAST
Repeati652 – 69140ARM 6Add
BLAST
Repeati694 – 73340ARM 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 5855Sequence analysisAdd
BLAST
Coiled coili133 – 244112Sequence analysisAdd
BLAST
Coiled coili1545 – 157834Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1345 – 142884Ser-richAdd
BLAST
Compositional biasi2202 – 2634433Ser-richAdd
BLAST
Compositional biasi2749 – 282375Ser-richAdd
BLAST

Sequence similaritiesi

Contains 7 ARM repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG004264.
KOiK02085.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 2 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 1 hit.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.

Sequencei

Sequence statusi: Complete.

P70039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASYDQLV KQVEALTMEN TNLRQELEDN SNHLTKLETE ATNMKEVLKQ
60 70 80 90 100
LQGSIEDEAM ASSGPIDLLE RFKDLNLDSS NIPAGKARPK MSMRSYGSRE
110 120 130 140 150
GSLSGHSGEC SPVPVGSFQR RGLLNGSRES AGYMEELEKE RLLLIAEHEK
160 170 180 190 200
EEKEKRWYYA QLQNLTKRID SLPLTENFSM QTDMTRRQLE YEARQIRAAM
210 220 230 240 250
EEQLGTCQDM EKRVQTRVGK IHQIEEEILR IRQLLQSQVA EAAERTPQSK
260 270 280 290 300
HDAGSRDAEK LPDGQGTSEI TASGNVGSGQ GSSSRADHDT TSVMSSNSTY
310 320 330 340 350
SVPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR
360 370 380 390 400
QSGCLPLLIQ LLHGNDKDSV LLGNSRGSKE ARASGSAALD NIIHSQPDDK
410 420 430 440 450
RGRREIRVLH LLEQIRAYCE TCWEWQEAHE QGMDQDKNPM PAPVDHQICP
460 470 480 490 500
AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL LQVDCEMYGL INDHYSVTLR
510 520 530 540 550
RYAGMALTNL TFGDVANKAT LCSMKSCMRA LVAQLKSESE DLQQVIASVL
560 570 580 590 600
RNLSWRADVN SKKTLREVGS VKALMECALD VKKESTLKSV LSALWNLSAH
610 620 630 640 650
CTENKADICS VDGALAFLVS TLTYRSQTNT LAIIESGGGI LRNVSSLIAT
660 670 680 690 700
NEDHRQILRE NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNAKDQEGL
710 720 730 740 750
WDMGAVSMLK NLIHSKHKMI AMGSAAALRN LMANRPAKYK DANIMSPGSS
760 770 780 790 800
VPSLHVRKQK ALEAELDAQH LSETFDNIDN LSPKTTHRNK QRHKQNLCSE
810 820 830 840 850
YALDSSRHDD SICRSDNFSI GNLTVLSPYI NTTVLPGSSS PRPTMDGSRP
860 870 880 890 900
EKDRERTAGL GNYHSTTESS GNSSKRIGIQ LSTTAQISKV MDEVSNIHLV
910 920 930 940 950
QENRSSGSAS EMHCMSDERN SQRKPSSNHP QSNPFTFTKA ESSTRGCPVA
960 970 980 990 1000
FMKMEYKMAS NDSLNSVSST EGYGKRGQVK PSVESYSEDD ESKFFSYGQY
1010 1020 1030 1040 1050
PAGLAHKIQS ANHMDDNDTE LDTPINYSLK YSDEQLNSGR QSPTQNERWS
1060 1070 1080 1090 1100
RPKHIIDSEM KQSEQRQPRT TKTTYSSYTE NKEEKHKKFP PHFNQSENVP
1110 1120 1130 1140 1150
AYTRSRGANN QVDQSRVSSN LSNNSKASKP HCQVDDYDDD KTTNFSERYS
1160 1170 1180 1190 1200
EEEQQEDETE RQNKYNIKAY ASEEHHGEQP IDYSRKYSTD VPSSAQKPSF
1210 1220 1230 1240 1250
PYSNNSSKQK PKKEQVSSNS NTPTPSPNSN RQNQLHPNSA QSRPGLNRPK
1260 1270 1280 1290 1300
QIPNKPPSIN QETIQTYCVE DTPICFSRGS SLSSLSSAED EIEGRERNSR
1310 1320 1330 1340 1350
GQESNNTLQI TEPKEISAVS KDGAVNETRS SVHHTRTKNN RLQTSNISPS
1360 1370 1380 1390 1400
DSSRHKSVEF SSGAKSPSKS GAQTPKSPPE HYVQETPLMF SRCTSGSSLD
1410 1420 1430 1440 1450
SFESHSIASS IASSVASEHM ISGIISPSDL PDSPGQTMPP SRSKTPPPPQ
1460 1470 1480 1490 1500
TVQAKKDGSK PIVPDEERGK VAKTAVHSAI QRVQVLQEAD TLLHFATEST
1510 1520 1530 1540 1550
PDGFSCASSL SALSLDEPYI QKDVQLKIMP PVLENDQGNK AEPEKEFIDN
1560 1570 1580 1590 1600
KAKKEDKRSE QEKDMLDDTD DDIDILEECI ISAMPRKPSR KNKKVPQPTP
1610 1620 1630 1640 1650
GKPPPPVARK PSQLPVYKLL SSQNRLQTQK HVNFTHSDDM PRVYCVEGTP
1660 1670 1680 1690 1700
INFSTATSLS DLTIESPPSE PTNDQPNTDS LSTDLEKRDT IPTEGRSTDD
1710 1720 1730 1740 1750
TDASKPLNPT TVLDEDKAEE GDILAECIHS AMPKGKSHKP YRVKKIMDQI
1760 1770 1780 1790 1800
NHTSAATSSG NSRSMQETDK NKPTSPVKPM PQSIGFKERL KKNTELKLNP
1810 1820 1830 1840 1850
NSENQYCDPR KPSSKKPSKV ANEKIPNNEE RTKGFAFDSP HHYTPIEGTP
1860 1870 1880 1890 1900
YCFSRNDSLS SLDFEDDDID LSKEKAELRK EKGTKDTDQK VKYKHENRAI
1910 1920 1930 1940 1950
NPMGKQDQTG PKSLGGRDQP KALVQKPTSF SSAAKGTQDR GGATDEKMEN
1960 1970 1980 1990 2000
FAIENTPVCF SRNSSLSSLS DIDQENNNKE TEPLKQTGTS ETQLGLRRPQ
2010 2020 2030 2040 2050
TSGYAPKSFH VEDTPVCFSR NSSLSSLSID SEDDLLQECI SSAMPKKRKP
2060 2070 2080 2090 2100
SKIKNEVGKS RSNSVGGILA EEPDLTLDLR DIQSPDSENA FSPDSENFDW
2110 2120 2130 2140 2150
KAIQEGANSI VSRLHQAAAA GSLSRQGSSD SDSILSLKSG ISLGSPFHLT
2160 2170 2180 2190 2200
LDKEEKTITS NKGPKILKPA EKSALENKKT EEEPKGIKGG KKVYKSLITG
2210 2220 2230 2240 2250
KSRSSSDFSS HCKQSVQTNM PSISRGRTMI HIPGVRASSP STSPVSKKGP
2260 2270 2280 2290 2300
VFKNVPSKGS NENPSSSSSP KGTKPLKSEL VYGSRPSSTP GGSSKGNSRS
2310 2320 2330 2340 2350
GSRDSASSRP SPQPLSRPLQ SPGRNSISPG KNGISPPNKF SQLPRTTSPS
2360 2370 2380 2390 2400
TASTKSSGSG RMSYTSPGRQ LSQPNLSKQS GLPKTHSSIP RSESASKSLN
2410 2420 2430 2440 2450
QNVNTGSNKK VELSRMSSTK SSGSESDRSE RPALVRQSTF IKEAPSPTLR
2460 2470 2480 2490 2500
RKLEESASFE SLSSSSRADS PPRSQTQTPA LSPSLPDMAL STHSIQAGGW
2510 2520 2530 2540 2550
RKMPPNLNPA AEHGDSRRRH DISRSHSESP SRLPITRSGT WKREHSKHSS
2560 2570 2580 2590 2600
SLPRVSTWRR TGSSSSILSA SSESSEKAKS EDEKQQVCSF PGPRSECSSS
2610 2620 2630 2640 2650
AKGTWRKIKE SEILETPSNG SSSTIAESNC SLESKTLVYQ MAPAVSKTED
2660 2670 2680 2690 2700
VWVRIEDCPI NNPRSGRSPT GNSPPVIDNV LDQGQKEEAA KDCHTRHNSG
2710 2720 2730 2740 2750
NGNVPLLENR QKSFIKVDGL DTKGTDPKSL INNQQETNEN TVAERTAFSS
2760 2770 2780 2790 2800
SSSSKHSSPS GTVAARVTPF NYNPSPRKSN GENSTSRPSQ IPTPVTNSTK
2810 2820
KRDSKTETTD SSGSQSPKRH SGSYLVTSV
Length:2,829
Mass (Da):310,882
Last modified:July 1, 1997 - v2
Checksum:i8A2BABDB7706E496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64442 mRNA. Translation: AAB41671.1.
RefSeqiNP_001084351.1. NM_001090882.1.
UniGeneiXl.8436.

Genome annotation databases

GeneIDi399455.
KEGGixla:399455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64442 mRNA. Translation: AAB41671.1.
RefSeqiNP_001084351.1. NM_001090882.1.
UniGeneiXl.8436.

3D structure databases

ProteinModelPortaliP70039.
SMRiP70039. Positions 2-55, 130-238, 1489-1532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi100780. 2 interactions.
IntActiP70039. 10 interactions.
MINTiMINT-7305229.

Proteomic databases

PRIDEiP70039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399455.
KEGGixla:399455.

Organism-specific databases

CTDi324.
XenbaseiXB-GENE-480859. apc.

Phylogenomic databases

HOVERGENiHBG004264.
KOiK02085.

Miscellaneous databases

PROiP70039.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 2 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 1 hit.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Vleminckx K., Wong E., Guger K., Gumbiner B.M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAPC_XENLA
AccessioniPrimary (citable) accession number: P70039
Secondary accession number(s): P79934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.