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Protein

POU domain, class 3, transcription factor 2-B

Gene

pou3f2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that may be implicated in patterning of the central nervous system during early development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi296 – 355HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 2-B
Alternative name(s):
Transcription factor POU3-B
Short name:
XlPOU3B
Gene namesi
Name:pou3f2-b
Synonyms:pou3b, pou3f2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-483178. pou3f2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007261 – 385POU domain, class 3, transcription factor 2-BAdd BLAST385

Expressioni

Tissue specificityi

Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.1 Publication

Developmental stagei

First expressed at the neurula stage.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP70030.
SMRiP70030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 278POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi183 – 190Poly-Gln8

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.
KOiK09365.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P70030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH
60 70 80 90 100
PLSHAHQWIT ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHGSGTLQHQ
110 120 130 140 150
SRAPHLVHPA HGNHHGPGAW RSTGSTHLSS MASSNGQGLL YSQPSFTVNG
160 170 180 190 200
MINPGSGQGM HHHGLRDSHD DHHGDHGHQQ PSQTQQQQQQ HSQLQGGHHD
210 220 230 240 250
HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI
260 270 280 290 300
CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR
310 320 330 340 350
TSIEVSVKGA LESHFLKCPK PAAQEITSLA DSLQLEKEVV RVWFCNRRQK
360 370 380
EKRMTPPGGT IPGAEDVYGA SRDTPPHLGV QTSVQ
Length:385
Mass (Da):41,985
Last modified:February 1, 1997 - v1
Checksum:i59001F5CCC0B2F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96423 Genomic DNA. Translation: CAA65283.1.
BC072060 mRNA. Translation: AAH72060.1.
BC160684 mRNA. Translation: AAI60684.1.
RefSeqiNP_001090220.1. NM_001096751.1.
UniGeneiXl.57289.

Genome annotation databases

GeneIDi779122.
KEGGixla:779122.

Similar proteinsi

Entry informationi

Entry nameiP3F2B_XENLA
AccessioniPrimary (citable) accession number: P70030
Secondary accession number(s): B1H1P3, Q6IP58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families