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P70030 (P3F2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 2-B
Alternative name(s):
Transcription factor POU3-B
Short name=XlPOU3B
Gene names
Name:pou3f2-b
Synonyms:pou3b, pou3f2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that may be implicated in patterning of the central nervous system during early development By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain. Ref.1

Developmental stage

First expressed at the neurula stage. Ref.1

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385POU domain, class 3, transcription factor 2-B
PRO_0000100726

Regions

Domain204 – 27875POU-specific
DNA binding296 – 35560Homeobox
Compositional bias183 – 1908Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
P70030 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 59001F5CCC0B2F3D

FASTA38541,985
        10         20         30         40         50         60 
MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH PLSHAHQWIT 

        70         80         90        100        110        120 
ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHGSGTLQHQ SRAPHLVHPA HGNHHGPGAW 

       130        140        150        160        170        180 
RSTGSTHLSS MASSNGQGLL YSQPSFTVNG MINPGSGQGM HHHGLRDSHD DHHGDHGHQQ 

       190        200        210        220        230        240 
PSQTQQQQQQ HSQLQGGHHD HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 

       250        260        270        280        290        300 
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR 

       310        320        330        340        350        360 
TSIEVSVKGA LESHFLKCPK PAAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT 

       370        380 
IPGAEDVYGA SRDTPPHLGV QTSVQ 

« Hide

References

« Hide 'large scale' references
[1]"Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis."
Baltzinger M., Relaix F., Remy P.
Mech. Dev. 58:103-114(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula and Tail bud.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96423 Genomic DNA. Translation: CAA65283.1.
BC072060 mRNA. Translation: AAH72060.1.
BC160684 mRNA. Translation: AAI60684.1.
RefSeqNP_001090220.1. NM_001096751.1.
UniGeneXl.57289.

3D structure databases

ProteinModelPortalP70030.
SMRP70030. Positions 210-356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779122.
KEGGxla:779122.

Organism-specific databases

CTD779122.
XenbaseXB-GENE-483178. pou3f2.

Phylogenomic databases

HOVERGENHBG053120.
KOK09365.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP3F2B_XENLA
AccessionPrimary (citable) accession number: P70030
Secondary accession number(s): B1H1P3, Q6IP58
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families