ID   P70012_XENLA            Unreviewed;      2253 AA.
AC   P70012;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   19-OCT-2011, entry version 41.
DE   SubName: Full=Nuclear/mitotic apparatus protein;
GN   Name=numa1; Synonyms=NuMA;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97053784; PubMed=8898198; DOI=10.1016/S0092-8674(00)81365-3;
RA   Merdes A., Ramyar K., Vechio J.D., Cleveland D.W.;
RT   "A complex of NuMA and cytoplasmic dynein is essential for mitotic
RT   spindle assembly.";
RL   Cell 87:447-458(1996).
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DR   EMBL; Y07624; CAA68905.1; -; mRNA.
DR   PIR; T30336; T30336.
DR   RefSeq; NP_001081559.1; NM_001088090.1.
DR   UniGene; Xl.1261; -.
DR   ProteinModelPortal; P70012; -.
DR   IntAct; P70012; 3.
DR   MINT; MINT-189361; -.
DR   GeneID; 397920; -.
DR   KEGG; xla:397920; -.
DR   CTD; 397920; -.
DR   Xenbase; XB-GENE-6252170; numa1.
DR   HOVERGEN; HBG052694; -.
PE   2: Evidence at transcript level;
SQ   SEQUENCE   2253 AA;  256797 MW;  158AEF149543E5B5 CRC64;
     MTSHSGKMEA LLCWVNSLKV DEPIERFSQL QDLSILLKVV GVLSGNSEET APVLQQDLEQ
     RLNCLCSFLQ RYCQTGSSAQ NLVQWQKILQ GENLEVELSK VIVILFYYST MSSKNPRKSE
     DIDHKTQTEL ASILRFVLDN EDALCLDDKL INFLKRKAPF PSSGNDPSSS SDAMTPNVSH
     RRKSEVRFLQ LHSVASSSTV KSLSADAPSS PMIEVLHTPQ FQMRRLKKQL SEVRECRDEL
     EVELAENRKH LAEKEAQISL LQQQIENLRI LRENQTELQE PKELEELREK NESLMIRLRD
     TLKQCQDMKA DKKLLERKND QLAEENGELS YKVRDLSNRL AQLQEALYET TEEQELSLSN
     WQQKQNQLES ELSGAVGEKK YLEEHNLILQ GKISMLEDQL KEMGEIDMPE TGDCMGDILK
     LDDLKQELAV LNTQCLSLKE QIHQMEEEKS TAEVEMEAQK SRFESEKGQL QEIVTNLQTS
     LSEITFQKER LDNEARAQQE HLMCQITTLK LEISKLKSSL VHKDEELKGI HHKVEEERNE
     KNQLLENFKM LGGNLIGITQ QLESKTKEVD YLREQQQKIL CERDSTLSTL NEYKCKKDEN
     SGVLNKTVKT LEQDHQTSLS VIEKLKSEKE ELASKVQDLD AKMLGLIAKC QNLDSENDSQ
     SKSHAATVES LKAQLSEQES QLKIYRKKVS SNELVSEENS KLKDQLLSVE ESLRHLREHL
     EKEKTKFAAS LDADLKRISH LEEEMKKLSE SRDEALHNLD EERTAGKKIE SQLKHLEEEY
     QKANESLQAK LAGSCAAIKQ REEERDELSK VVDIWKAKYG ESQQKIAQNS CHMQEQTEEL
     KKTHSDVYQQ LEGERSKVLM IEAKASETKS SQLEKINQLE GELSAANACI KEREAEEKKL
     VSALHSAEEK LKIAYQGESE RLSHLETALS NAKQDLDCLA KELSDEKYKK AEFEAMVKVL
     KEQNSERIAS LESELKNSLA VVKERKCESE KLSGEVEHLK RQLDDSSQKH KEALAQKNIE
     IKQLINAKEK ATSDLAIKSE MGAQLQKAVD THKSEFSALQ NELSRSLDLL ALKEGEVERL
     NKEAALRQEE IQQQQQTITK LTEEETALAA LKDKVALQEK EIKQQVQATK GAEKEMAKLK
     SVISEKSKRI ECLEQDIQNQ KRDLSCIQEQ HQSKLGESQG LQALIADLEK KCKEQKELIC
     EAQNKAAEAK TLASEKASVS ERQLEGIQAL EIEIGKERQK ACDLQKQLEL SWAVQEEKET
     ELQALKKELF HKVQELEQSQ TSFTDSSGEA LLYLSEAQER QQALTEAKEQ AEQYQKEIEM
     KNKEVNSLQA EIKILSSKVT TNEEVSVDFE QRLLKETSKS AKLEEKMQKL HMELEASFKE
     LLEKNCAIDC LTTEAQNLKG EADQQRMAVD SLQQKLSSKA ETNHTLQQEI QAWQKNCAEK
     EQQICSLQQN LKSNQSLLEE FASLKHSYQE IIAERDLMQE KHQEELLSHK KLTERFQAEL
     EKAKEDMTEI VLLKEKLHNQ ELQLHKFQSE NSYSLTQISH LQQVNSQLLG ANQSLSQISD
     QGAKKLESEM STLKEQHKEE MKTLRLQYEK TLREGNKQVQ ETSLQLETVT SKYDHVKSKV
     LKDQKTFQEE KQRLLLQVQE LNKQLSQQEK TIRSQQQKLK QREGETHEEA DKSHKRVLEL
     ESQLEQQTQA VEHYKAQMEK AKVHYDAKKK QNQELSEELQ SHIKQQEHLS KENADLKAES
     EQLHKELQHS LLQSKEVEQN CKNLSNRVRS LEASWSTLTG QLRDPGKFQL ATAFHEESGH
     FCAPRQTRSH ADVSIDSLDL SFGEDQLLNS TSERCNEEPA TSSVHASSPD SLISGQLPKK
     VESLESLYFT PIPTRAQSKL ESSIGSIGDL SLDSSKKTQS ARRRTMQIIN ITMTKKTKEE
     PESANTSFYS LRSAPSYQSL HLQNPRRAGR PPAAISAPAL ASLPSQESLA KTEHFSSDDS
     LNNLPGYQHP TRRSARLSQT GGRSSFYMST CQDEPDPQDD WTRIAELQAR NKTCPPHLKT
     SYPLESRPSI FSSTITDEEV KLGDPKETLR RATLLPGQIQ DSMTSTRRQT LAVPGAEHLK
     GHNISTRQQM KRVSEESHYG PDTPEAKKTA TCFPRPMTPK DKHDTRRVST MESKGSSSHQ
     QAQPTRRQAT AFSIFNTPKK LGNSLLKRGL NKKTTPKNSP RGRGANGSTS STSNKPSHLS
     LRKSPSQRSP RVSTAKSPRA SNKLFERKQQ RNK
//