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Protein

Nucleoside diphosphate kinase A1

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131ATPBy similarity
Binding sitei61 – 611ATPBy similarity
Binding sitei89 – 891ATPBy similarity
Binding sitei95 – 951ATPBy similarity
Binding sitei106 – 1061ATPBy similarity
Binding sitei116 – 1161ATPBy similarity
Active sitei119 – 1191Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase A1 (EC:2.7.4.6)
Short name:
NDK A1
Short name:
NDP kinase A1
Alternative name(s):
NM23/nucleoside diphosphate kinase A1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Nucleoside diphosphate kinase A1PRO_0000137120Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP70010.

Structurei

3D structure databases

ProteinModelPortaliP70010.
SMRiP70010. Positions 3-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

HOVERGENiHBG000423.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANKERTFI AIKPDGVQRG LMGDIIKRFE QKGFRLVAMK FQQASQDLLR
60 70 80 90 100
QHYIDLKDRP FYPGLVEYMS SGPVLAMVWE GLNVVKTGRV MLGETNPADS
110 120 130 140 150
KPGTIRGDFC IQVGRNIIHG SDSVESANKE IALWFKDEEL VENKSCAYEW

VYEN
Length:154
Mass (Da):17,489
Last modified:February 1, 1997 - v1
Checksum:iDDE3A5621ADB6333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97900 mRNA. Translation: CAA66474.1.
BC079795 mRNA. Translation: AAH79795.1.
UniGeneiXl.2830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97900 mRNA. Translation: CAA66474.1.
BC079795 mRNA. Translation: AAH79795.1.
UniGeneiXl.2830.

3D structure databases

ProteinModelPortaliP70010.
SMRiP70010. Positions 3-153.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP70010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000423.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Several genes encode the metastasis suppressor NM23/nucleoside diphosphate kinase of Xenopus laevis."
    Ouatas T., Abdallah B., Gasmi L., Mazabraud A.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiNDKA1_XENLA
AccessioniPrimary (citable) accession number: P70010
Secondary accession number(s): Q68FI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.