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Protein
Submitted name:

Hepatocyte growth factor-like protein

Gene

mst1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionSerine protease homologUniRule annotation

Protein family/group databases

MEROPSiS01.977.

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor-like proteinImported
Gene namesi
Name:mst1Imported
ORF Names:XELAEV_18023809mgImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
Proteomesi
  • UP000186698 Componenti: Chromosome 4l

Organism-specific databases

XenbaseiXB-GENE-865755. mst1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501050345929 – 717Sequence analysisAdd BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi200 ↔ 277PROSITE-ProRule annotation
Disulfide bondi221 ↔ 260PROSITE-ProRule annotation
Disulfide bondi249 ↔ 272PROSITE-ProRule annotation
Disulfide bondi312 ↔ 351PROSITE-ProRule annotation
Disulfide bondi340 ↔ 363PROSITE-ProRule annotation
Disulfide bondi378 ↔ 455PROSITE-ProRule annotation
Disulfide bondi399 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 114AppleInterPro annotationAdd BLAST97
Domaini118 – 195KringleInterPro annotationAdd BLAST78
Domaini199 – 277KringleInterPro annotationAdd BLAST79
Domaini290 – 369KringleInterPro annotationAdd BLAST80
Domaini377 – 455KringleInterPro annotationAdd BLAST79
Domaini487 – 715Peptidase S1InterPro annotationAdd BLAST229

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG004381.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
PfamiView protein in Pfam
PF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiView protein in PROSITE
PS00021. KRINGLE_1. 3 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

P70006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHITVPSNM KSCLFLLCFN AAVFFVTGTA HRSALNDYQR SKGLELVHMN
60 70 80 90 100
EGGVKQEVQA EIQICAKQCS DLLDCRSFDY NWKSQSCRLL PWTQNSSNVL
110 120 130 140 150
LQRNVQYDLY QKKDYIRDCV VGNGNTYRGT VSKTKNGRTC QHWRLKFPHD
160 170 180 190 200
HKFSPTHWPE LEENYCRNPD SDPEGLWCYT TDKNIRHQYC GIKKCEDAVC
210 220 230 240 250
LTCNGEDYRG SVDRTESGKE CQRWDLQAPH THPYKPEKYP DKSLDDNYCR
260 270 280 290 300
NPDSSERPWC YTTDPNVERE FCHITKCKKQ RISNIEITST CFKERGEGYR
310 320 330 340 350
GKANTTTSGI PCQRWDTQAP HVHRFLPEKY PCKGLDENYC RNPVGSEAPW
360 370 380 390 400
CFTTLKNMRM AYCFQIKRCT DDVVEPECYH GNGELYRGRV SKTRKGIMCR
410 420 430 440 450
RWEEKQNDLE LSLAQPYLVP LEENYCRNPD RDSHGPWCYT MDPNTPFDYC
460 470 480 490 500
ALKPCAGDKV LTLEEAESIA FDSCGKRTDR LLRKSRIVGG EPGNSPWTVS
510 520 530 540 550
LRNRQGEHFC GGSLVKENWV ISTRQCFSSC DADLSGYEAV MGTLFKNPSP
560 570 580 590 600
DDPDRQSVPI SKIVCGPSDS SLVMLKLQWP VTLNSRVALI CLPPERYIVP
610 620 630 640 650
EDTKCEIAGW GDTQGTGHDN VLKIASFYIL SNDNCNKNYR SQRNKVLDNE
660 670 680 690 700
MCTKPMTVDV GACEGDYGGP LACLTHDCWV LEGVIVPARG CGKKNQPAIF
710
TRVSVYVDWI NKVMKMV
Length:717
Mass (Da):82,018
Last modified:February 1, 1997 - v1
Checksum:i6F877A432C8CDD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08734 mRNA. Translation: CAA69989.1.
CM004472 Genomic DNA. Translation: OCT85637.1.
RefSeqiNP_001079527.1. NM_001086058.1.
UniGeneiXl.216.

Genome annotation databases

GeneIDi379214.
KEGGixla:379214.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiP70006_XENLA
AccessioniPrimary (citable) accession number: P70006
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported