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Protein
Submitted name:

Hepatocyte growth factor-like protein

Gene

mst1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Serine protease homologUniRule annotation

Protein family/group databases

MEROPSiS01.977.

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor-like proteinImported
Gene namesi
Name:mst1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865755. mst1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 717689Sequence analysisPRO_5004161217Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliP70006.
SMRiP70006. Positions 487-714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11497AppleInterPro annotationAdd
BLAST
Domaini118 – 19578KringleInterPro annotationAdd
BLAST
Domaini199 – 27779KringleInterPro annotationAdd
BLAST
Domaini290 – 36980KringleInterPro annotationAdd
BLAST
Domaini377 – 45579KringleInterPro annotationAdd
BLAST
Domaini487 – 715229Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

KringleSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG004381.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHITVPSNM KSCLFLLCFN AAVFFVTGTA HRSALNDYQR SKGLELVHMN
60 70 80 90 100
EGGVKQEVQA EIQICAKQCS DLLDCRSFDY NWKSQSCRLL PWTQNSSNVL
110 120 130 140 150
LQRNVQYDLY QKKDYIRDCV VGNGNTYRGT VSKTKNGRTC QHWRLKFPHD
160 170 180 190 200
HKFSPTHWPE LEENYCRNPD SDPEGLWCYT TDKNIRHQYC GIKKCEDAVC
210 220 230 240 250
LTCNGEDYRG SVDRTESGKE CQRWDLQAPH THPYKPEKYP DKSLDDNYCR
260 270 280 290 300
NPDSSERPWC YTTDPNVERE FCHITKCKKQ RISNIEITST CFKERGEGYR
310 320 330 340 350
GKANTTTSGI PCQRWDTQAP HVHRFLPEKY PCKGLDENYC RNPVGSEAPW
360 370 380 390 400
CFTTLKNMRM AYCFQIKRCT DDVVEPECYH GNGELYRGRV SKTRKGIMCR
410 420 430 440 450
RWEEKQNDLE LSLAQPYLVP LEENYCRNPD RDSHGPWCYT MDPNTPFDYC
460 470 480 490 500
ALKPCAGDKV LTLEEAESIA FDSCGKRTDR LLRKSRIVGG EPGNSPWTVS
510 520 530 540 550
LRNRQGEHFC GGSLVKENWV ISTRQCFSSC DADLSGYEAV MGTLFKNPSP
560 570 580 590 600
DDPDRQSVPI SKIVCGPSDS SLVMLKLQWP VTLNSRVALI CLPPERYIVP
610 620 630 640 650
EDTKCEIAGW GDTQGTGHDN VLKIASFYIL SNDNCNKNYR SQRNKVLDNE
660 670 680 690 700
MCTKPMTVDV GACEGDYGGP LACLTHDCWV LEGVIVPARG CGKKNQPAIF
710
TRVSVYVDWI NKVMKMV
Length:717
Mass (Da):82,018
Last modified:February 1, 1997 - v1
Checksum:i6F877A432C8CDD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08734 mRNA. Translation: CAA69989.1.
RefSeqiNP_001079527.1. NM_001086058.1.
UniGeneiXl.216.

Genome annotation databases

GeneIDi379214.
KEGGixla:379214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08734 mRNA. Translation: CAA69989.1.
RefSeqiNP_001079527.1. NM_001086058.1.
UniGeneiXl.216.

3D structure databases

ProteinModelPortaliP70006.
SMRiP70006. Positions 487-714.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379214.
KEGGixla:379214.

Organism-specific databases

CTDi4485.
XenbaseiXB-GENE-865755. mst1.

Phylogenomic databases

HOVERGENiHBG004381.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation."
    Aberger F., Schmidt G., Richter K.
    Mech. Dev. 54:23-37(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported and LiverImported.

Entry informationi

Entry nameiP70006_XENLA
AccessioniPrimary (citable) accession number: P70006
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.