P69987 (YSCU_YERPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Yop proteins translocation protein U

Gene names

Name:	yscU
Ordered Locus Names:	pYV0074

Encoded on

Plasmid pIB1 Ref.1
Plasmid pYV Ref.2

Organism

Yersinia pseudotuberculosis serotype I (strain IP32953) [Complete proteome] [HAMAP]

Taxonomic identifier

273123 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pseudotuberculosis

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the yop secretion machinery.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the type III secretion exporter family.

Ontologies

Keywords
Biological process	Protein transport Transport Virulence
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein secretion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Yop proteins translocation protein U		PRO_0000180962
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P69987 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: BFD4977E22D2D3A3	FASTA	354	40,382
	10 20 30 40 50 60 MSGEKTEQPT PKKIRDARKK GQVAKSKEVV STALIVALSA MLMGLSDYYF EHFSKLMLIP 70 80 90 100 110 120 AEQSYLPFSQ ALSYVVDNVL LEFFYLCFPL LTVAALMAIA SHVVQYGFLI SGEAIKPDIK 130 140 150 160 170 180 KINPIEGAKR IFSIKSLVEF LKSILKVVLL SILIWIIIKG NLVTLLQLPT CGIECITPLL 190 200 210 220 230 240 GQILRQLMVI CTVGFVVISI ADYAFEYYQY IKELKMSKDE IKREYKEMEG SPEIKSKRRQ 250 260 270 280 290 300 FHQEIQSRNM RENVKRSSVV VANPTHIAIG ILYKRGETPL PLVTFKYTDA QVQTVRKIAE 310 320 330 340 350 EEGVPILQRI PLARALYWDA LVDHYIPAEQ IEATAEVLRW LERQNIEKQH SEML

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium." Bergman T., Erickson K., Galyov E., Persson C., Wolf-Watz H. J. Bacteriol. 176:2619-2626(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: YPIII / Serotype O:3.
[2]	"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E. Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25667 Genomic DNA. Translation: AAA27681.1. BX936399 Genomic DNA. Translation: CAF25417.1.
RefSeq	YP_068483.1. NC_006153.2.
3D structure databases
ProteinModelPortal	P69987.
ModBase	Search...
Protein-protein interaction databases
STRING	273123.pYV0074.
Protein family/group databases
MEROPS	N06.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF25417; CAF25417; pYV0074.
GeneID	2952967.
KEGG	yps:pYV0074.
PATRIC	18637902. VBIYerPse22266_0078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4792.
HOGENOM	HOG000253898.
KO	K03229.
OMA	QRMSHED.
ProtClustDB	CLSK862137.
Family and domain databases
InterPro	IPR006307. T3SS_EscU. IPR006135. T3SS_substrate_exporter. [Graphical view]
Pfam	PF01312. Bac_export_2. 1 hit. [Graphical view]
PRINTS	PR00950. TYPE3IMSPROT.
TIGRFAMs	TIGR01404. FlhB_rel_III. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YSCU_YERPS

Accession

Primary (citable) accession number: P69987
Secondary accession number(s): P40300, Q663J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program