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P69952

- EFTU_STRP1

UniProt

P69952 - EFTU_STRP1

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Protein

Elongation factor Tu

Gene

tuf

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi84 – 885GTPUniRule annotation
Nucleotide bindingi139 – 1424GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-502-MONOMER.
SPYO293653:GHFC-563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:SPy_0611, M5005_Spy0508
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Elongation factor TuPRO_0000091409Add
BLAST

Proteomic databases

PaxDbiP69952.
PRIDEiP69952.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi160490.SPy_0611.

Structurei

3D structure databases

ProteinModelPortaliP69952.
SMRiP69952. Positions 2-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 207198tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1By similarity
Regioni63 – 675G2By similarity
Regioni84 – 874G3By similarity
Regioni139 – 1424G4By similarity
Regioni177 – 1793G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDNIEMVG.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69952-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEKYDRSK PHVNIGTIGH VDHGKTTLTA AITTVLARRL PSSVNQPKDY
60 70 80 90 100
ASIDAAPEER ERGITINTAH VEYETATRHY AHIDAPGHAD YVKNMITGAA
110 120 130 140 150
QMDGAILVVA STDGPMPQTR EHILLSRQVG VKHLIVFMNK VDLVDDEELL
160 170 180 190 200
ELVEMEIRDL LSEYDFPGDD LPVIQGSALK ALEGDTKFED IIMELMDTVD
210 220 230 240 250
SYIPEPERDT DKPLLLPVED VFSITGRGTV ASGRIDRGTV RVNDEIEIVG
260 270 280 290 300
IKEETKKAVV TGVEMFRKQL DEGLAGDNVG ILLRGVQRDE IERGQVIAKP
310 320 330 340 350
SSINPHTKFK GEVYILSKDE GGRHTPFFNN YRPQFYFRTT DVTGSIELPA
360 370 380 390
GTEMVMPGDN VTINVELIHP IAVEQGTTFS IREGGRTVGS GIVSEIEA
Length:398
Mass (Da):43,856
Last modified:January 4, 2005 - v1
Checksum:i21E0B20A8DD21AFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33586.1.
CP000017 Genomic DNA. Translation: AAZ51126.1.
RefSeqiNP_268865.1. NC_002737.1.
YP_281871.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33586; AAK33586; SPy_0611.
AAZ51126; AAZ51126; M5005_Spy0508.
GeneIDi3572407.
900817.
KEGGispy:SPy_0611.
spz:M5005_Spy_0508.
PATRICi19714909. VBIStrPyo79812_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33586.1 .
CP000017 Genomic DNA. Translation: AAZ51126.1 .
RefSeqi NP_268865.1. NC_002737.1.
YP_281871.1. NC_007297.1.

3D structure databases

ProteinModelPortali P69952.
SMRi P69952. Positions 2-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0611.

Proteomic databases

PaxDbi P69952.
PRIDEi P69952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33586 ; AAK33586 ; SPy_0611 .
AAZ51126 ; AAZ51126 ; M5005_Spy0508 .
GeneIDi 3572407.
900817.
KEGGi spy:SPy_0611.
spz:M5005_Spy_0508.
PATRICi 19714909. VBIStrPyo79812_0523.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi DNIEMVG.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-502-MONOMER.
SPYO293653:GHFC-563-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiEFTU_STRP1
AccessioniPrimary (citable) accession number: P69952
Secondary accession number(s): P82559, Q48ZU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3