Reviewed,
UniProtKB/Swiss-Prot P69942 (GLNE_MYCTU)
Last modified
June 16, 2009.
Version 20.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutamate-ammonia-ligase adenylyltransferase EC=2.7.7.42 Alternative name(s): [Glutamate--ammonia-ligase] adenylyltransferase Glutamine-synthetase adenylyltransferase Short name=ATase | ||||||
| Gene names |
| ||||||
| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 994 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Adenylation and deadenylation of glutamine synthetase By similarity. |
| Catalytic activity | ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP MF_00802 |
| Sequence similarities | Belongs to the glnE family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW [glutamate-ammonia-ligase] adenylyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 994 | 994 | Glutamate-ammonia-ligase adenylyltransferase HAMAP MF_00802 | PRO_0000209257 | |||||
Regions | |||||||||
| Region | 150 – 341 | 192 | GlnE 1 HAMAP MF_00802 | ||||||
| Region | 645 – 852 | 208 | GlnE 2 HAMAP MF_00802 | ||||||
Experimental info | |||||||||
| Sequence conflict | 676 | 1 | T → S in AAK46564. Ref.2 | ||||||
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.  Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| BX842579 Genomic DNA. Translation: CAA94664.1. AE000516 Genomic DNA. Translation: AAK46564.1. | |
| PIR | A70776. |
| RefSeq | NP_216737.1. NP_336750.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 887995. 924147. |
| GenomeReviews | Gene locus MT2279 in contig AE000516_GR. Gene locus Rv2221c in contig AL123456_GR. |
| KEGG | mtc:MT2279. mtu:Rv2221c. |
| TIGR | MT2279. |
Organism-specific databases | |
| TubercuList | Rv2221c. |
Phylogenomic databases | |
| HOGENOM | P69942. |
| OMA | P69942. WERYAMI. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.42. 809. |
Family and domain databases | |
| HAMAP | MF_00802. [Tree] |
| InterPro | IPR005190. GlnE. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view] |
| Pfam | PF08335. GlnD_UR_UTase. 2 hits. PF03710. GlnE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GLNE_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P69942 Secondary accession number(s): Q10379 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
