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P69940 (KBX1_TITSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin TsTXK-beta
Alternative name(s):
Potassium channel toxin beta-KTx 1
Tityustoxin K-beta
Short name=TsTX K beta
Short name=TsTX-K beta
Short name=TsTXKbeta
Ts8
TsK2
OrganismTityus serrulatus (Brazilian scorpion)
Taxonomic identifier6887 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Selectively blocks voltage-gated noninactivating potassium channels (Kv) from rat brain synaptosomes. Ref.4

Subcellular location

Secreted Ref.3.

Tissue specificity

Expressed by the venom gland. Ref.3

Miscellaneous

It is not known if the sequenced fragment corresponding to the propeptide is the result of the post-translational maturation process, or if it has a biological activity of its own (Ref.3).

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Mass spectrometry

Molecular mass is 6716.15 Da from positions 26 - 85. Determined by ESI. Ref.2

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 278 Probable
PRO_0000035342
Chain28 – 8760Potassium channel toxin TsTXK-beta
PRO_0000035343

Amino acid modifications

Disulfide bond56 ↔ 77 By similarity
Disulfide bond63 ↔ 82 By similarity
Disulfide bond67 ↔ 84 By similarity

Sequences

Sequence LengthMass (Da)Tools
P69940 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: ADCA961D54841F62

FASTA879,729
        10         20         30         40         50         60 
MERKLALLLI LGMVTLASCG LREKHVQKLV ALIPNDQLRS ILKAVVHKVA KTQFGCPAYE 

        70         80 
GYCNDHCNDI ERKDGECHGF KCKCAKD 

« Hide

References

[1]"Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom."
Kalapothakis E., Jardim S., Magalhaes A.C., Mendes T.M., De Marco L., Afonso L.C.C., Chavez-Olortegui C.
Toxicon 39:679-685(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]"Evidence for a new class of scorpion toxins active against K+ channels."
Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-87, MASS SPECTROMETRY.
Tissue: Venom gland.
[3]"Tityus serrulatus venom peptidomics: assessing venom peptide diversity."
Rates B., Ferraz K.K., Borges M.H., Richardson M., De Lima M.E., Pimenta A.M.
Toxicon 52:611-618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-47, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Venom.
[4]"Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes."
Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
Proc. Natl. Acad. Sci. U.S.A. 91:1475-1479(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-72, FUNCTION.
Tissue: Venom.
[5]Erratum
Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
Proc. Natl. Acad. Sci. U.S.A. 93:12051-12051(1996)
[6]"Tityus serrulatus scorpion venom and toxins: an overview."
Cologna C.T., Marcussi S., Giglio J.R., Soares A.M., Arantes E.C.
Protein Pept. Lett. 16:920-932(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKBX1_TITSE
AccessionPrimary (citable) accession number: P69940
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries