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P69940

- KBX1_TITSE

UniProt

P69940 - KBX1_TITSE

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Protein

Potassium channel toxin TsTXK-beta

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Selectively blocks voltage-gated noninactivating potassium channels (Kv) from rat brain synaptosomes.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin TsTXK-beta
Alternative name(s):
Potassium channel toxin beta-KTx 1
Tityustoxin K-beta
Short name:
TsTX K beta
Short name:
TsTX-K beta
Short name:
TsTXKbeta
Ts8
TsK2
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 2781 PublicationPRO_0000035342
Chaini28 – 8760Potassium channel toxin TsTXK-betaPRO_0000035343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 77By similarity
Disulfide bondi63 ↔ 82By similarity
Disulfide bondi67 ↔ 84By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69940-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERKLALLLI LGMVTLASCG LREKHVQKLV ALIPNDQLRS ILKAVVHKVA
60 70 80
KTQFGCPAYE GYCNDHCNDI ERKDGECHGF KCKCAKD
Length:87
Mass (Da):9,729
Last modified:November 13, 2007 - v2
Checksum:iADCA961D54841F62
GO

Mass spectrometryi

Molecular mass is 6716.15 Da from positions 26 - 85. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom."
    Kalapothakis E., Jardim S., Magalhaes A.C., Mendes T.M., De Marco L., Afonso L.C.C., Chavez-Olortegui C.
    Toxicon 39:679-685(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Evidence for a new class of scorpion toxins active against K+ channels."
    Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
    FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-87, MASS SPECTROMETRY.
    Tissue: Venom gland.
  3. "Tityus serrulatus venom peptidomics: assessing venom peptide diversity."
    Rates B., Ferraz K.K., Borges M.H., Richardson M., De Lima M.E., Pimenta A.M.
    Toxicon 52:611-618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-47, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Venom.
  4. "Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes."
    Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
    Proc. Natl. Acad. Sci. U.S.A. 91:1475-1479(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-72, FUNCTION.
    Tissue: Venom.
  5. Erratum
    Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
    Proc. Natl. Acad. Sci. U.S.A. 93:12051-12051(1996)
  6. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiKBX1_TITSE
AccessioniPrimary (citable) accession number: P69940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

It is not known if the sequenced fragment corresponding to the propeptide is the result of the post-translational maturation process, or if it has a biological activity of its own.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3