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P69940

- KBX1_TITSE

UniProt

P69940 - KBX1_TITSE

Protein

Potassium channel toxin TsTXK-beta

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Selectively blocks voltage-gated noninactivating potassium channels (Kv) from rat brain synaptosomes.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin TsTXK-beta
    Alternative name(s):
    Potassium channel toxin beta-KTx 1
    Tityustoxin K-beta
    Short name:
    TsTX K beta
    Short name:
    TsTX-K beta
    Short name:
    TsTXKbeta
    Ts8
    TsK2
    OrganismiTityus serrulatus (Brazilian scorpion)
    Taxonomic identifieri6887 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 2781 PublicationPRO_0000035342
    Chaini28 – 8760Potassium channel toxin TsTXK-betaPRO_0000035343Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 77By similarity
    Disulfide bondi63 ↔ 82By similarity
    Disulfide bondi67 ↔ 84By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P69940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKLALLLI LGMVTLASCG LREKHVQKLV ALIPNDQLRS ILKAVVHKVA   50
    KTQFGCPAYE GYCNDHCNDI ERKDGECHGF KCKCAKD 87
    Length:87
    Mass (Da):9,729
    Last modified:November 13, 2007 - v2
    Checksum:iADCA961D54841F62
    GO

    Mass spectrometryi

    Molecular mass is 6716.15 Da from positions 26 - 85. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom."
      Kalapothakis E., Jardim S., Magalhaes A.C., Mendes T.M., De Marco L., Afonso L.C.C., Chavez-Olortegui C.
      Toxicon 39:679-685(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    2. "Evidence for a new class of scorpion toxins active against K+ channels."
      Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
      FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-87, MASS SPECTROMETRY.
      Tissue: Venom gland.
    3. "Tityus serrulatus venom peptidomics: assessing venom peptide diversity."
      Rates B., Ferraz K.K., Borges M.H., Richardson M., De Lima M.E., Pimenta A.M.
      Toxicon 52:611-618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-47, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Venom.
    4. "Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes."
      Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
      Proc. Natl. Acad. Sci. U.S.A. 91:1475-1479(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-72, FUNCTION.
      Tissue: Venom.
    5. Erratum
      Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.
      Proc. Natl. Acad. Sci. U.S.A. 93:12051-12051(1996)
    6. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiKBX1_TITSE
    AccessioniPrimary (citable) accession number: P69940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    It is not known if the sequenced fragment corresponding to the propeptide is the result of the post-translational maturation process, or if it has a biological activity of its own.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3