Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P69939

- KBX1_ANDAU

UniProt

P69939 - KBX1_ANDAU

Protein

Potassium channel toxin AaTXK-beta

Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potassium channel toxin AaTXK-beta: blocks voltage-gated potassium channels (Kv) By similarity. Does not activate Kv7 channels.By similarity1 Publication
    Potassium channel toxin AaTXK-beta(2-64): peptide activator of Kv7.4/KCNQ4 channels. Also acts as a subtype-selective activator of channels formed by Kv7.3 (KCNQ3), Kv7.2/Kv7.3 (KCNQ2/KCNQ3), Kv7.5/Kv7.3 (KCNQ3/KCNQ5) subunits.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin AaTXK-beta
    Short name:
    Toxin AaTXKbeta
    Alternative name(s):
    Potassium channel toxin AaTXK-beta(1-64)
    Potassium channel toxin beta-KTx 2
    Cleaved into the following chain:
    OrganismiAndroctonus australis (Sahara scorpion)
    Taxonomic identifieri6858 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 278PRO_0000035340
    Chaini28 – 9164Potassium channel toxin AaTXK-betaPRO_0000035341Add
    BLAST
    Chaini29 – 9163Potassium channel toxin AaTXK-beta(2-64)PRO_0000424386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 78By similarity
    Disulfide bondi64 ↔ 83By similarity
    Disulfide bondi68 ↔ 85By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer (both chains).1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P69939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV   50
    GKTQFGCPAY QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F 91
    Length:91
    Mass (Da):10,148
    Last modified:January 4, 2005 - v1
    Checksum:iC4A3D2D45E2BD917
    GO

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for a new class of scorpion toxins active against K+ channels."
      Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
      FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    2. "Subtype-selective activation of Kv7 channels by AaTXKbeta(2-64), a novel toxin variant from the Androctonus australis scorpion venom."
      Landoulsi Z., Miceli F., Palmese A., Amoresano A., Marino G., El Ayeb M., Taglialatela M., Benkhalifa R.
      Mol. Pharmacol. 84:763-773(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (POTASSIUM CHANNEL TOXIN AATXK-BETA AND POTASSIUM CHANNEL TOXIN AATXK-BETA(2-64)), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
      Tissue: Venom.

    Entry informationi

    Entry nameiKBX1_ANDAU
    AccessioniPrimary (citable) accession number: P69939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3