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P69939

- KBX1_ANDAU

UniProt

P69939 - KBX1_ANDAU

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Protein
Potassium channel toxin AaTXK-beta
Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Potassium channel toxin AaTXK-beta: blocks voltage-gated potassium channels (Kv) By similarity. Does not activate Kv7 channels.1 Publication
Potassium channel toxin AaTXK-beta(2-64): peptide activator of Kv7.4/KCNQ4 channels. Also acts as a subtype-selective activator of channels formed by Kv7.3 (KCNQ3), Kv7.2/Kv7.3 (KCNQ2/KCNQ3), Kv7.5/Kv7.3 (KCNQ3/KCNQ5) subunits.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin AaTXK-beta
Short name:
Toxin AaTXKbeta
Alternative name(s):
Potassium channel toxin AaTXK-beta(1-64)
Potassium channel toxin beta-KTx 2
Cleaved into the following chain:
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 278
PRO_0000035340
Chaini28 – 9164Potassium channel toxin AaTXK-beta
PRO_0000035341Add
BLAST
Chaini29 – 9163Potassium channel toxin AaTXK-beta(2-64)
PRO_0000424386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 78 By similarity
Disulfide bondi64 ↔ 83 By similarity
Disulfide bondi68 ↔ 85 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (both chains).1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69939-1 [UniParc]FASTAAdd to Basket

« Hide

MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV   50
GKTQFGCPAY QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F 91
Length:91
Mass (Da):10,148
Last modified:January 4, 2005 - v1
Checksum:iC4A3D2D45E2BD917
GO

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence for a new class of scorpion toxins active against K+ channels."
    Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
    FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Subtype-selective activation of Kv7 channels by AaTXKbeta(2-64), a novel toxin variant from the Androctonus australis scorpion venom."
    Landoulsi Z., Miceli F., Palmese A., Amoresano A., Marino G., El Ayeb M., Taglialatela M., Benkhalifa R.
    Mol. Pharmacol. 84:763-773(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (POTASSIUM CHANNEL TOXIN AATXK-BETA AND POTASSIUM CHANNEL TOXIN AATXK-BETA(2-64)), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
    Tissue: Venom.

Entry informationi

Entry nameiKBX1_ANDAU
AccessioniPrimary (citable) accession number: P69939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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