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P69939 (KBX1_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin AaTXK-beta

Short name=Toxin AaTXKbeta
Alternative name(s):
Potassium channel toxin AaTXK-beta(1-64)
Potassium channel toxin beta-KTx 2

Cleaved into the following chain:

  1. Potassium channel toxin AaTXK-beta(2-64)
OrganismAndroctonus australis (Sahara scorpion)
Taxonomic identifier6858 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potassium channel toxin AaTXK-beta: blocks voltage-gated potassium channels (Kv) By similarity. Does not activate Kv7 channels. Ref.2

Potassium channel toxin AaTXK-beta(2-64): peptide activator of Kv7.4/KCNQ4 channels. Also acts as a subtype-selective activator of channels formed by Kv7.3 (KCNQ3), Kv7.2/Kv7.3 (KCNQ2/KCNQ3), Kv7.5/Kv7.3 (KCNQ3/KCNQ5) subunits. Ref.2

Subunit structure

Monomer (both chains). Ref.2

Subcellular location

Secreted Ref.2.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 278
PRO_0000035340
Chain28 – 9164Potassium channel toxin AaTXK-beta
PRO_0000035341
Chain29 – 9163Potassium channel toxin AaTXK-beta(2-64)
PRO_0000424386

Amino acid modifications

Disulfide bond57 ↔ 78 By similarity
Disulfide bond64 ↔ 83 By similarity
Disulfide bond68 ↔ 85 By similarity

Sequences

Sequence LengthMass (Da)Tools
P69939 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: C4A3D2D45E2BD917

FASTA9110,148
        10         20         30         40         50         60 
MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV GKTQFGCPAY 

        70         80         90 
QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F 

« Hide

References

[1]"Evidence for a new class of scorpion toxins active against K+ channels."
Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]"Subtype-selective activation of Kv7 channels by AaTXKbeta(2-64), a novel toxin variant from the Androctonus australis scorpion venom."
Landoulsi Z., Miceli F., Palmese A., Amoresano A., Marino G., El Ayeb M., Taglialatela M., Benkhalifa R.
Mol. Pharmacol. 84:763-773(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (POTASSIUM CHANNEL TOXIN AATXK-BETA AND POTASSIUM CHANNEL TOXIN AATXK-BETA(2-64)), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKBX1_ANDAU
AccessionPrimary (citable) accession number: P69939
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries