P69939 (KBX1_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin AaTXK-beta Short name=Toxin AaTXKbeta Alternative name(s): Potassium channel toxin beta-KTx 2
Organism	Androctonus australis (Sahara scorpion)
Taxonomic identifier	6858 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Blocks voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 27	8	Probable		PRO_0000035340
	Chain	28 – 91	64	Potassium channel toxin AaTXK-beta		PRO_0000035341
Amino acid modifications
	Disulfide bond	57 ↔ 78		By similarity
	Disulfide bond	64 ↔ 83		By similarity
	Disulfide bond	68 ↔ 85		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P69939 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: C4A3D2D45E2BD917	FASTA	91	10,148
	10 20 30 40 50 60 MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV GKTQFGCPAY 70 80 90 QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F

References

[1]	"Evidence for a new class of scorpion toxins active against K+ channels." Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F. FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KBX1_ANDAU

Accession

Primary (citable) accession number: P69939

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	April 3, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program