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Protein

Potassium channel toxin AaTXK-beta

Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel toxin AaTXK-beta: blocks voltage-gated potassium channels (Kv) (By similarity). Does not activate Kv7 channels.By similarity1 Publication
Potassium channel toxin AaTXK-beta(2-64): peptide activator of Kv7.4/KCNQ4 channels. Also acts as a subtype-selective activator of channels formed by Kv7.3 (KCNQ3), Kv7.2/Kv7.3 (KCNQ2/KCNQ3), Kv7.5/Kv7.3 (KCNQ3/KCNQ5) subunits.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin AaTXK-beta
Short name:
Toxin AaTXKbeta
Alternative name(s):
Potassium channel toxin AaTXK-beta(1-64)
Potassium channel toxin beta-KTx 2
Cleaved into the following chain:
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 278PRO_0000035340
Chaini28 – 9164Potassium channel toxin AaTXK-betaPRO_0000035341Add
BLAST
Chaini29 – 9163Potassium channel toxin AaTXK-beta(2-64)PRO_0000424386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 78By similarity
Disulfide bondi64 ↔ 83By similarity
Disulfide bondi68 ↔ 85By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (both chains).1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV
60 70 80 90
GKTQFGCPAY QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F
Length:91
Mass (Da):10,148
Last modified:January 4, 2005 - v1
Checksum:iC4A3D2D45E2BD917
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence for a new class of scorpion toxins active against K+ channels."
    Legros C., Ceard B., Bougis P.E., Martin-Eauclaire M.-F.
    FEBS Lett. 431:375-380(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Subtype-selective activation of Kv7 channels by AaTXKbeta(2-64), a novel toxin variant from the Androctonus australis scorpion venom."
    Landoulsi Z., Miceli F., Palmese A., Amoresano A., Marino G., El Ayeb M., Taglialatela M., Benkhalifa R.
    Mol. Pharmacol. 84:763-773(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (POTASSIUM CHANNEL TOXIN AATXK-BETA AND POTASSIUM CHANNEL TOXIN AATXK-BETA(2-64)), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
    Tissue: Venom.

Entry informationi

Entry nameiKBX1_ANDAU
AccessioniPrimary (citable) accession number: P69939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: January 7, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.