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Protein

Potassium channel toxin AaTXK-beta

Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel toxin AaTXK-beta: blocks voltage-gated potassium channels (Kv) (By similarity). Does not activate Kv7 channels.By similarity1 Publication
Potassium channel toxin AaTXK-beta(2-64): peptide activator of Kv7.4/KCNQ4 channels. Also acts as a subtype-selective activator of channels formed by Kv7.3 (KCNQ3), Kv7.2/Kv7.3 (KCNQ2/KCNQ3), Kv7.5/Kv7.3 (KCNQ3/KCNQ5) subunits.1 Publication

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin AaTXK-beta
Short name:
Toxin AaTXKbeta
Alternative name(s):
Potassium channel toxin AaTXK-beta(1-64)
Potassium channel toxin beta-KTx 2
Cleaved into the following chain:
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003534020 – 278
ChainiPRO_000003534128 – 91Potassium channel toxin AaTXK-betaAdd BLAST64
ChainiPRO_000042438629 – 91Potassium channel toxin AaTXK-beta(2-64)Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 78By similarity
Disulfide bondi64 ↔ 83By similarity
Disulfide bondi68 ↔ 85By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (both chains).1 Publication

Structurei

3D structure databases

SMRiP69939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF14866. Toxin_38. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNLVVLLF LGMVALSSCG LREKHVQKLV KYAVPVGTLR TILQTVVHKV
60 70 80 90
GKTQFGCPAY QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F
Length:91
Mass (Da):10,148
Last modified:January 4, 2005 - v1
Checksum:iC4A3D2D45E2BD917
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKBX1_ANDAU
AccessioniPrimary (citable) accession number: P69939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: May 10, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families