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Protein

Quaternary ammonium compound-resistance protein SugE

Gene

sugE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations.1 Publication

GO - Molecular functioni

  • drug transporter activity Source: EcoCyc
  • substrate-specific transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • drug export Source: EcoCyc
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:SUGE-MONOMER.
ECOL316407:JW5738-MONOMER.

Protein family/group databases

TCDBi2.A.7.1.4. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Quaternary ammonium compound-resistance protein SugE
Gene namesi
Name:sugE
Ordered Locus Names:b4148, JW5738
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11616. sugE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 28CytoplasmicSequence analysis7
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 57PeriplasmicSequence analysis8
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 81CytoplasmicSequence analysis3
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 105PeriplasmicSequence analysis3

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080951 – 105Quaternary ammonium compound-resistance protein SugEAdd BLAST105

Proteomic databases

PaxDbiP69937.
PRIDEiP69937.

Interactioni

Protein-protein interaction databases

BioGridi4262698. 178 interactors.
STRINGi511145.b4148.

Structurei

3D structure databases

ProteinModelPortaliP69937.
SMRiP69937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KPY. Bacteria.
COG2076. LUCA.
HOGENOMiHOG000268007.
InParanoidiP69937.
KOiK11741.
OMAiLEVGWAI.
PhylomeDBiP69937.

Family and domain databases

InterProiIPR000390. Small_multidrug_res.
[Graphical view]
PfamiPF00893. Multi_Drug_Res. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWIILVIAG LLEVVWAVGL KYTHGFSRLT PSVITVTAMI VSMALLAWAM
60 70 80 90 100
KSLPVGTAYA VWTGIGAVGA AITGIVLLGE SANPMRLASL ALIVLGIIGL

KLSTH
Length:105
Mass (Da):10,900
Last modified:January 4, 2005 - v1
Checksum:iC4686D9EDC1B7D08
GO

Sequence cautioni

The sequence AAA97047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA49570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69949 Genomic DNA. Translation: CAA49570.1. Different initiation.
X69949 Genomic DNA. Translation: CAA49571.1.
U21726 Genomic DNA. Translation: AAC46453.1.
U14003 Genomic DNA. Translation: AAA97047.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77108.2.
AP009048 Genomic DNA. Translation: BAE78152.1.
PIRiS56376.
RefSeqiNP_418572.4. NC_000913.3.
WP_000118482.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77108; AAC77108; b4148.
BAE78152; BAE78152; BAE78152.
GeneIDi948671.
KEGGiecj:JW5738.
eco:b4148.
PATRICi32123869. VBIEscCol129921_4282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69949 Genomic DNA. Translation: CAA49570.1. Different initiation.
X69949 Genomic DNA. Translation: CAA49571.1.
U21726 Genomic DNA. Translation: AAC46453.1.
U14003 Genomic DNA. Translation: AAA97047.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77108.2.
AP009048 Genomic DNA. Translation: BAE78152.1.
PIRiS56376.
RefSeqiNP_418572.4. NC_000913.3.
WP_000118482.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP69937.
SMRiP69937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262698. 178 interactors.
STRINGi511145.b4148.

Protein family/group databases

TCDBi2.A.7.1.4. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP69937.
PRIDEiP69937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77108; AAC77108; b4148.
BAE78152; BAE78152; BAE78152.
GeneIDi948671.
KEGGiecj:JW5738.
eco:b4148.
PATRICi32123869. VBIEscCol129921_4282.

Organism-specific databases

EchoBASEiEB1573.
EcoGeneiEG11616. sugE.

Phylogenomic databases

eggNOGiENOG4105KPY. Bacteria.
COG2076. LUCA.
HOGENOMiHOG000268007.
InParanoidiP69937.
KOiK11741.
OMAiLEVGWAI.
PhylomeDBiP69937.

Enzyme and pathway databases

BioCyciEcoCyc:SUGE-MONOMER.
ECOL316407:JW5738-MONOMER.

Miscellaneous databases

PROiP69937.

Family and domain databases

InterProiIPR000390. Small_multidrug_res.
[Graphical view]
PfamiPF00893. Multi_Drug_Res. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGE_ECOLI
AccessioniPrimary (citable) accession number: P69937
Secondary accession number(s): P30743, Q2M6F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.

Caution

Was originally (PubMed:8096175) thought to suppress a groEL mutation and mimic the effect of groE overexpression. This was later shown (PubMed:11948170) to be probably due to an artifact.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.