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Protein

Quaternary ammonium compound-resistance protein SugE

Gene

sugE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations.1 Publication

Miscellaneous

Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.

GO - Molecular functioni

  • drug transporter activity Source: EcoCyc
  • substrate-specific transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • drug export Source: EcoCyc
  • transmembrane transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:SUGE-MONOMER.

Protein family/group databases

TCDBi2.A.7.1.4. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Quaternary ammonium compound-resistance protein SugE
Gene namesi
Name:sugE
Ordered Locus Names:b4148, JW5738
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11616. sugE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 28CytoplasmicSequence analysis7
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 57PeriplasmicSequence analysis8
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 81CytoplasmicSequence analysis3
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 105PeriplasmicSequence analysis3

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080951 – 105Quaternary ammonium compound-resistance protein SugEAdd BLAST105

Proteomic databases

PaxDbiP69937.
PRIDEiP69937.

Interactioni

Protein-protein interaction databases

BioGridi4262698. 178 interactors.
STRINGi316385.ECDH10B_4343.

Structurei

3D structure databases

ProteinModelPortaliP69937.
SMRiP69937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KPY. Bacteria.
COG2076. LUCA.
HOGENOMiHOG000268007.
InParanoidiP69937.
KOiK11741.
PhylomeDBiP69937.

Family and domain databases

InterProiView protein in InterPro
IPR000390. Small_multidrug_res.
PfamiView protein in Pfam
PF00893. Multi_Drug_Res. 1 hit.

Sequencei

Sequence statusi: Complete.

P69937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWIILVIAG LLEVVWAVGL KYTHGFSRLT PSVITVTAMI VSMALLAWAM
60 70 80 90 100
KSLPVGTAYA VWTGIGAVGA AITGIVLLGE SANPMRLASL ALIVLGIIGL

KLSTH
Length:105
Mass (Da):10,900
Last modified:January 4, 2005 - v1
Checksum:iC4686D9EDC1B7D08
GO

Sequence cautioni

The sequence AAA97047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA49570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69949 Genomic DNA. Translation: CAA49570.1. Different initiation.
X69949 Genomic DNA. Translation: CAA49571.1.
U21726 Genomic DNA. Translation: AAC46453.1.
U14003 Genomic DNA. Translation: AAA97047.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77108.2.
AP009048 Genomic DNA. Translation: BAE78152.1.
PIRiS56376.
RefSeqiNP_418572.4. NC_000913.3.
WP_000118482.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77108; AAC77108; b4148.
BAE78152; BAE78152; BAE78152.
GeneIDi948671.
KEGGiecj:JW5738.
eco:b4148.
PATRICifig|1411691.4.peg.2550.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSUGE_ECOLI
AccessioniPrimary (citable) accession number: P69937
Secondary accession number(s): P30743, Q2M6F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 5, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:8096175) thought to suppress a groEL mutation and mimic the effect of groE overexpression. This was later shown (PubMed:11948170) to be probably due to an artifact.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families