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P69923

- FUCI_SHIFL

UniProt

P69923 - FUCI_SHIFL

Protein

L-fucose isomerase

Gene

fucI

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.By similarity

    Catalytic activityi

    L-fucopyranose = L-fuculose.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei337 – 3371Proton acceptorBy similarity
    Metal bindingi337 – 3371ManganeseBy similarity
    Active sitei361 – 3611Proton acceptorBy similarity
    Metal bindingi361 – 3611ManganeseBy similarity
    Metal bindingi528 – 5281ManganeseBy similarity

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomerase (EC:5.3.1.25)
    Alternative name(s):
    6-deoxy-L-galactose isomerase
    FucIase
    Gene namesi
    Name:fucI
    Ordered Locus Names:SF2816, S3011
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591L-fucose isomerasePRO_0000204151Add
    BLAST

    Proteomic databases

    PaxDbiP69923.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi198214.SF2816.

    Structurei

    3D structure databases

    ProteinModelPortaliP69923.
    SMRiP69923. Positions 1-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P69923-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL LTEKLRHACG    50
    AAVECVISDT CIAGMAEAAA CEEKFSSQNV GLTITVTPCW CYGSETIDMD 100
    PTRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS 150
    IPADVEEKLL RFARAGLAVA SMKGKSYLSL GGVSMGIAGS IVDHNFFESW 200
    LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY GEDENNKQYQ 250
    RNAEQSRAVL RESLLMAMCI RDMMQGNSKL ADIGRVEESL GYNAIAAGFQ 300
    GQRHWTDQYP NGDTAEAILN SSFDWNGVRE PFVVATENDS LNGVAMLMGH 350
    QLTGTAQVFA DVRTYWSPEA IERVTGHKLD GLAEHGIIHL INSGSAALDG 400
    SCKQRDSEGN PTMKPHWEIS QQEADACLAA TEWCPAIHEY FRGGGYSSRF 450
    LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VELPKDVHDI LNKRTNSTWP 500
    TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF ITLASMLRIP 550
    VCMHNVEETK VYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 591
    Length:591
    Mass (Da):64,977
    Last modified:January 4, 2005 - v1
    Checksum:iE6245DEEDF34EF9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44304.1.
    AE014073 Genomic DNA. Translation: AAP18129.1.
    RefSeqiNP_708597.1. NC_004337.2.
    NP_838319.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN44304; AAN44304; SF2816.
    AAP18129; AAP18129; S3011.
    GeneIDi1027300.
    1079277.
    KEGGisfl:SF2816.
    sfx:S3011.
    PATRICi18707701. VBIShiFle31049_3305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44304.1 .
    AE014073 Genomic DNA. Translation: AAP18129.1 .
    RefSeqi NP_708597.1. NC_004337.2.
    NP_838319.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P69923.
    SMRi P69923. Positions 1-591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2816.

    Proteomic databases

    PaxDbi P69923.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN44304 ; AAN44304 ; SF2816 .
    AAP18129 ; AAP18129 ; S3011 .
    GeneIDi 1027300.
    1079277.
    KEGGi sfl:SF2816.
    sfx:S3011.
    PATRICi 18707701. VBIShiFle31049_3305.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiFUCI_SHIFL
    AccessioniPrimary (citable) accession number: P69923
    Secondary accession number(s): P11552
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3