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P69898

- VL1_HPV6A

UniProt

P69898 - VL1_HPV6A

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Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 6a
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1
Gene namesi
Name:L1
OrganismiHuman papillomavirus type 6a
Taxonomic identifieri37122 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007675: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. T=7 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Major capsid protein L1PRO_0000133489Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP69898.
SMRiP69898. Positions 20-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae L1 protein family.Curated

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
InterProiIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamiPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

P69898 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MWRPSDSTVY VPPPNPVSKV VATDAYVTRT NIFYHASSSR LLAVGHPYFS
60 70 80 90 100
IKRANKTVVP KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT
110 120 130 140 150
GLEVGRGQPL GVGVSGHPFL NKYDDVENSG SGGNPGQDNR VNVGMDYKQT
160 170 180 190 200
QLCMVGCAPP LGEHWGKGKQ CTNTPVQAGD CPPLELITSV IQDGDMVDTG
210 220 230 240 250
FGAMNFADLQ TNKSDVPIDI CGTTCKYPDY LQMAADPYGD RLFFFLRKEQ
260 270 280 290 300
MFARHFFNRA GEVGEPVPDT LIIKGSGNRT SVGSSIYVNT PSGSLVSSEA
310 320 330 340 350
QLFNKPYWLQ KAQGHNNGIC WGNQLFVTVV DTTRSTNMTL CASVTTSSTY
360 370 380 390 400
TNSDYKEYMR HVEEYDLQFI FQLCSITLSA EVMAYIHTMN PSVLEDWNFG
410 420 430 440 450
LSPPPNGTLE DTYRYVQSQA ITCQKPTPEK EKPDPYKNLS FWEVNLKEKF
460 470 480 490 500
SSELDQYPLG RKFLLQSGYR GRSSIRTGVK RPAVSKASAA PKRKRAKTKR
Length:500
Mass (Da):55,597
Last modified:July 21, 1986 - v1
Checksum:iB6168D0F76A287F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41216 Genomic DNA. Translation: AAA74218.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41216 Genomic DNA. Translation: AAA74218.1 .

3D structure databases

ProteinModelPortali P69898.
SMRi P69898. Positions 20-469.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.175.20. 1 hit.
InterProi IPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view ]
Pfami PF00500. Late_protein_L1. 1 hit.
[Graphical view ]
PRINTSi PR00865. HPVCAPSIDL1.
SUPFAMi SSF88648. SSF88648. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saccharomyces cerevisiae."
    Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U.
    Virology 209:506-518(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVL1_HPV6A
AccessioniPrimary (citable) accession number: P69898
Secondary accession number(s): P03100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3