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P69898

- VL1_HPV6A

UniProt

P69898 - VL1_HPV6A

Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 6a
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major capsid protein L1
    Gene namesi
    Name:L1
    OrganismiHuman papillomavirus type 6a
    Taxonomic identifieri37122 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007675: Genome

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. T=7 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, T=7 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Major capsid protein L1PRO_0000133489Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP69898.
    SMRiP69898. Positions 20-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the papillomaviridae L1 protein family.Curated

    Family and domain databases

    Gene3Di2.60.175.20. 1 hit.
    InterProiIPR002210. Capsid_L1_Papillomavir.
    IPR011222. dsDNA_vir_gr_I_capsid.
    [Graphical view]
    PfamiPF00500. Late_protein_L1. 1 hit.
    [Graphical view]
    PRINTSiPR00865. HPVCAPSIDL1.
    SUPFAMiSSF88648. SSF88648. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P69898-1 [UniParc]FASTAAdd to Basket

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    MWRPSDSTVY VPPPNPVSKV VATDAYVTRT NIFYHASSSR LLAVGHPYFS    50
    IKRANKTVVP KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT 100
    GLEVGRGQPL GVGVSGHPFL NKYDDVENSG SGGNPGQDNR VNVGMDYKQT 150
    QLCMVGCAPP LGEHWGKGKQ CTNTPVQAGD CPPLELITSV IQDGDMVDTG 200
    FGAMNFADLQ TNKSDVPIDI CGTTCKYPDY LQMAADPYGD RLFFFLRKEQ 250
    MFARHFFNRA GEVGEPVPDT LIIKGSGNRT SVGSSIYVNT PSGSLVSSEA 300
    QLFNKPYWLQ KAQGHNNGIC WGNQLFVTVV DTTRSTNMTL CASVTTSSTY 350
    TNSDYKEYMR HVEEYDLQFI FQLCSITLSA EVMAYIHTMN PSVLEDWNFG 400
    LSPPPNGTLE DTYRYVQSQA ITCQKPTPEK EKPDPYKNLS FWEVNLKEKF 450
    SSELDQYPLG RKFLLQSGYR GRSSIRTGVK RPAVSKASAA PKRKRAKTKR 500
    Length:500
    Mass (Da):55,597
    Last modified:July 21, 1986 - v1
    Checksum:iB6168D0F76A287F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41216 Genomic DNA. Translation: AAA74218.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41216 Genomic DNA. Translation: AAA74218.1 .

    3D structure databases

    ProteinModelPortali P69898.
    SMRi P69898. Positions 20-469.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.175.20. 1 hit.
    InterProi IPR002210. Capsid_L1_Papillomavir.
    IPR011222. dsDNA_vir_gr_I_capsid.
    [Graphical view ]
    Pfami PF00500. Late_protein_L1. 1 hit.
    [Graphical view ]
    PRINTSi PR00865. HPVCAPSIDL1.
    SUPFAMi SSF88648. SSF88648. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saccharomyces cerevisiae."
      Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U.
      Virology 209:506-518(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiVL1_HPV6A
    AccessioniPrimary (citable) accession number: P69898
    Secondary accession number(s): P03100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3