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P69898 (VL1_HPV6A) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major capsid protein L1
Gene names
Name:L1
OrganismHuman papillomavirus type 6a [Complete proteome]
Taxonomic identifier37122 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.

Subunit structure

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the papillomaviridae L1 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Major capsid protein L1
PRO_0000133489

Sequences

Sequence LengthMass (Da)Tools
P69898 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: B6168D0F76A287F7

FASTA50055,597
        10         20         30         40         50         60 
MWRPSDSTVY VPPPNPVSKV VATDAYVTRT NIFYHASSSR LLAVGHPYFS IKRANKTVVP 

        70         80         90        100        110        120 
KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT GLEVGRGQPL GVGVSGHPFL 

       130        140        150        160        170        180 
NKYDDVENSG SGGNPGQDNR VNVGMDYKQT QLCMVGCAPP LGEHWGKGKQ CTNTPVQAGD 

       190        200        210        220        230        240 
CPPLELITSV IQDGDMVDTG FGAMNFADLQ TNKSDVPIDI CGTTCKYPDY LQMAADPYGD 

       250        260        270        280        290        300 
RLFFFLRKEQ MFARHFFNRA GEVGEPVPDT LIIKGSGNRT SVGSSIYVNT PSGSLVSSEA 

       310        320        330        340        350        360 
QLFNKPYWLQ KAQGHNNGIC WGNQLFVTVV DTTRSTNMTL CASVTTSSTY TNSDYKEYMR 

       370        380        390        400        410        420 
HVEEYDLQFI FQLCSITLSA EVMAYIHTMN PSVLEDWNFG LSPPPNGTLE DTYRYVQSQA 

       430        440        450        460        470        480 
ITCQKPTPEK EKPDPYKNLS FWEVNLKEKF SSELDQYPLG RKFLLQSGYR GRSSIRTGVK 

       490        500 
RPAVSKASAA PKRKRAKTKR 

« Hide

References

[1]"Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saccharomyces cerevisiae."
Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U.
Virology 209:506-518(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41216 Genomic DNA. Translation: AAA74218.1.

3D structure databases

ProteinModelPortalP69898.
SMRP69898. Positions 20-469.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.175.20. 1 hit.
InterProIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSPR00865. HPVCAPSIDL1.
SUPFAMSSF88648. SSF88648. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVL1_HPV6A
AccessionPrimary (citable) accession number: P69898
Secondary accession number(s): P03100
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families