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P69898

- VL1_HPV6A

UniProt

P69898 - VL1_HPV6A

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Protein
Major capsid protein L1
Gene
L1
Organism
Human papillomavirus type 6a
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1
Gene namesi
Name:L1
OrganismiHuman papillomavirus type 6a
Taxonomic identifieri37122 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007675: Genome

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. T=7 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Major capsid protein L1
PRO_0000133489Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.

Structurei

3D structure databases

ProteinModelPortaliP69898.
SMRiP69898. Positions 20-469.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
InterProiIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamiPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

P69898-1 [UniParc]FASTAAdd to Basket

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MWRPSDSTVY VPPPNPVSKV VATDAYVTRT NIFYHASSSR LLAVGHPYFS    50
IKRANKTVVP KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT 100
GLEVGRGQPL GVGVSGHPFL NKYDDVENSG SGGNPGQDNR VNVGMDYKQT 150
QLCMVGCAPP LGEHWGKGKQ CTNTPVQAGD CPPLELITSV IQDGDMVDTG 200
FGAMNFADLQ TNKSDVPIDI CGTTCKYPDY LQMAADPYGD RLFFFLRKEQ 250
MFARHFFNRA GEVGEPVPDT LIIKGSGNRT SVGSSIYVNT PSGSLVSSEA 300
QLFNKPYWLQ KAQGHNNGIC WGNQLFVTVV DTTRSTNMTL CASVTTSSTY 350
TNSDYKEYMR HVEEYDLQFI FQLCSITLSA EVMAYIHTMN PSVLEDWNFG 400
LSPPPNGTLE DTYRYVQSQA ITCQKPTPEK EKPDPYKNLS FWEVNLKEKF 450
SSELDQYPLG RKFLLQSGYR GRSSIRTGVK RPAVSKASAA PKRKRAKTKR 500
Length:500
Mass (Da):55,597
Last modified:July 21, 1986 - v1
Checksum:iB6168D0F76A287F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41216 Genomic DNA. Translation: AAA74218.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41216 Genomic DNA. Translation: AAA74218.1 .

3D structure databases

ProteinModelPortali P69898.
SMRi P69898. Positions 20-469.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.175.20. 1 hit.
InterProi IPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view ]
Pfami PF00500. Late_protein_L1. 1 hit.
[Graphical view ]
PRINTSi PR00865. HPVCAPSIDL1.
SUPFAMi SSF88648. SSF88648. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saccharomyces cerevisiae."
    Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U.
    Virology 209:506-518(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVL1_HPV6A
AccessioniPrimary (citable) accession number: P69898
Secondary accession number(s): P03100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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