##gff-version 3 P69892 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14087393,ECO:0000269|PubMed:5554303,ECO:0000269|Ref.7;Dbxref=PMID:14087393,PMID:5554303 P69892 UniProtKB Chain 2 147 . . . ID=PRO_0000053254;Note=Hemoglobin subunit gamma-2 P69892 UniProtKB Binding site 64 64 . . . Note=Distal binding residue;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P80044 P69892 UniProtKB Binding site 93 93 . . . Note=Proximal binding residue;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:881729,ECO:0007744|PDB:1FDH,ECO:0007744|PDB:4MQJ,ECO:0007744|PDB:4MQK;Dbxref=PMID:881729 P69892 UniProtKB Modified residue 2 2 . . . Note=N-acetylglycine%3B in form Hb F1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:5554303;Dbxref=PMID:5554303 P69892 UniProtKB Modified residue 13 13 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68871 P69892 UniProtKB Modified residue 45 45 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Modified residue 51 51 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Modified residue 53 53 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Modified residue 60 60 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68871 P69892 UniProtKB Modified residue 83 83 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68871 P69892 UniProtKB Modified residue 94 94 . . . Note=S-nitrosocysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68871 P69892 UniProtKB Modified residue 140 140 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Modified residue 143 143 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Modified residue 144 144 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P69892 UniProtKB Natural variant 2 2 . . . ID=VAR_003123;Note=In Malaysia. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:4837284;Dbxref=dbSNP:rs36006195,PMID:4837284 P69892 UniProtKB Natural variant 6 6 . . . ID=VAR_003126;Note=In Meinohama. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6172403;Dbxref=dbSNP:rs34263826,PMID:6172403 P69892 UniProtKB Natural variant 8 8 . . . ID=VAR_003129;Note=In Auckland. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:4429671;Dbxref=dbSNP:rs34501593,PMID:4429671 P69892 UniProtKB Natural variant 9 9 . . . ID=VAR_020643;Note=In Albaicin. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2435680;Dbxref=dbSNP:rs35521813,PMID:2435680 P69892 UniProtKB Natural variant 9 9 . . . ID=VAR_020644;Note=In Albaicin. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2435680;Dbxref=dbSNP:rs35521813,PMID:2435680 P69892 UniProtKB Natural variant 13 13 . . . ID=VAR_020645;Note=In Heather. T->R;Dbxref=dbSNP:rs281864890 P69892 UniProtKB Natural variant 16 16 . . . ID=VAR_003131;Note=In Catalonia. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1706691;Dbxref=dbSNP:rs34438981,PMID:1706691 P69892 UniProtKB Natural variant 17 17 . . . ID=VAR_003132;Note=In Melbourne. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:836882;Dbxref=dbSNP:rs34907654,PMID:836882 P69892 UniProtKB Natural variant 18 18 . . . ID=VAR_020646;Note=In Clamart. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10722115;Dbxref=dbSNP:rs35621390,PMID:10722115 P69892 UniProtKB Natural variant 20 20 . . . ID=VAR_020647;Note=In Ouled Rabah. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10722115;Dbxref=dbSNP:rs34018799,PMID:10722115 P69892 UniProtKB Natural variant 21 21 . . . ID=VAR_030496;Note=In Bron. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16370494;Dbxref=dbSNP:rs63751196,PMID:16370494 P69892 UniProtKB Natural variant 22 22 . . . ID=VAR_003133;Note=In Saskatoon. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8144355;Dbxref=dbSNP:rs33955330,PMID:8144355 P69892 UniProtKB Natural variant 22 22 . . . ID=VAR_003134;Note=In Fuchu. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3120456;Dbxref=dbSNP:rs33955330,PMID:3120456 P69892 UniProtKB Natural variant 23 23 . . . ID=VAR_020648;Note=In Urumqi. D->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2420748,ECO:0000269|PubMed:8718700;Dbxref=dbSNP:rs281864891,PMID:2420748,PMID:8718700 P69892 UniProtKB Natural variant 23 23 . . . ID=VAR_003136;Note=In Granada. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2459082;Dbxref=dbSNP:rs281864891,PMID:2459082 P69892 UniProtKB Natural variant 26 26 . . . ID=VAR_003137;Note=In Cosenza. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1726095;Dbxref=dbSNP:rs35687396,PMID:1726095 P69892 UniProtKB Natural variant 27 27 . . . ID=VAR_003139;Note=In Oakland. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2442122;Dbxref=dbSNP:rs35654328,PMID:2442122 P69892 UniProtKB Natural variant 35 35 . . . ID=VAR_003140;Note=In Tokyo. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2581919;Dbxref=dbSNP:rs35885783,PMID:2581919 P69892 UniProtKB Natural variant 39 39 . . . ID=VAR_030497;Note=In Bonheiden%3B causes severe hereditary hemolytic anemia. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15645283;Dbxref=dbSNP:rs35799058,PMID:15645283 P69892 UniProtKB Natural variant 41 41 . . . ID=VAR_003144;Note=In Veleta. R->G;Dbxref=dbSNP:rs34532478 P69892 UniProtKB Natural variant 41 41 . . . ID=VAR_020649;Note=In Austell. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2459083;Dbxref=dbSNP:rs281864892,PMID:2459083 P69892 UniProtKB Natural variant 42 42 . . . ID=VAR_003146;Note=In TNCY%3B hemoglobin Cincinnati. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7741137;Dbxref=dbSNP:rs34878913,PMID:7741137 P69892 UniProtKB Natural variant 45 45 . . . ID=VAR_003148;Note=In Lodz. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6814491;Dbxref=dbSNP:rs34017450,PMID:6814491 P69892 UniProtKB Natural variant 56 56 . . . ID=VAR_003150;Note=In Kingston. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6186522;Dbxref=dbSNP:rs34915311,PMID:6186522 P69892 UniProtKB Natural variant 60 60 . . . ID=VAR_003151;Note=In Emirates. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7558873;Dbxref=dbSNP:rs28933078,PMID:7558873 P69892 UniProtKB Natural variant 60 60 . . . ID=VAR_003152;Note=In Sacromonte. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7558873;Dbxref=dbSNP:rs28933078,PMID:7558873 P69892 UniProtKB Natural variant 64 64 . . . ID=VAR_025336;Note=In TNCY%3B hemoglobin M-Circleville. H->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19065339,ECO:0000269|Ref.3;Dbxref=PMID:19065339 P69892 UniProtKB Natural variant 64 64 . . . ID=VAR_003154;Note=In TNCY%3B hemoglobin Osaka%3B the presence of a tyrosine causes the formation of a covalent link with heme iron%2C so that the iron is stabilized in the ferric form%3B when this occurs methemoglobin is formed%2C oxygen can no longer bind to heme and cyanosis occurs. H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19065339,ECO:0000269|PubMed:2483933;Dbxref=dbSNP:rs34474104,PMID:19065339,PMID:2483933 P69892 UniProtKB Natural variant 66 66 . . . ID=VAR_003155;Note=In Clarke. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2442123;Dbxref=dbSNP:rs34019507,PMID:2442123 P69892 UniProtKB Natural variant 67 67 . . . ID=VAR_003157;Note=In Brooklyn. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1703138;Dbxref=dbSNP:rs34264694,PMID:1703138 P69892 UniProtKB Natural variant 67 67 . . . ID=VAR_003156;Note=In Shanghai. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2579547;Dbxref=dbSNP:rs35481866,PMID:2579547 P69892 UniProtKB Natural variant 68 68 . . . ID=VAR_065950;Note=In TNCY%3B hemoglobin Toms River%3B the side chain of methionine decreases both the affinity of oxygen for binding to the mutant hemoglobin subunit via steric hindrance and the rate at which it does so%3B the mutant methionine is converted to aspartic acid post-translationally. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21561349;Dbxref=dbSNP:rs587776864,PMID:21561349 P69892 UniProtKB Natural variant 73 73 . . . ID=VAR_020650;Note=In Minoo. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3120456;Dbxref=dbSNP:rs281860594,PMID:3120456 P69892 UniProtKB Natural variant 76 76 . . . ID=VAR_020651;Note=In LesVos/Waynesboro/Charlotte. I->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1714434,ECO:0000269|PubMed:8566966,ECO:0000269|PubMed:8718701;Dbxref=dbSNP:rs104894225,PMID:1714434,PMID:8566966,PMID:8718701 P69892 UniProtKB Natural variant 76 76 . . . ID=VAR_030498;Note=In Coigneres. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11791877;Dbxref=dbSNP:rs34363111,PMID:11791877 P69892 UniProtKB Natural variant 78 78 . . . ID=VAR_003162;Note=In Kennestone. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6192110;Dbxref=dbSNP:rs34150306,PMID:6192110 P69892 UniProtKB Natural variant 81 81 . . . ID=VAR_020652;Note=In Marietta. D->N;Dbxref=dbSNP:rs63751148 P69892 UniProtKB Natural variant 93 93 . . . ID=VAR_003166;Note=In TNCY%3B hemoglobin Fort Ripley. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2470017;Dbxref=dbSNP:rs35103459,PMID:2470017 P69892 UniProtKB Natural variant 95 95 . . . ID=VAR_003167;Note=In Columbus-Ga. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6186636;Dbxref=dbSNP:rs35812514,PMID:6186636 P69892 UniProtKB Natural variant 102 102 . . . ID=VAR_003169;Note=In La Grange. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6206897;Dbxref=dbSNP:rs34876238,PMID:6206897 P69892 UniProtKB Natural variant 105 105 . . . ID=VAR_003170;Note=In Macedonia-II. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7713741;Dbxref=dbSNP:rs35717854,PMID:7713741 P69892 UniProtKB Natural variant 106 106 . . . ID=VAR_073159;Note=In TNCY%3B hemoglobin F-Brugine/Feldkirch%3B lowered affinity for oxygen. L->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24502349;Dbxref=PMID:24502349 P69892 UniProtKB Natural variant 118 118 . . . ID=VAR_003171;Note=In Malta-1. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:5792729;Dbxref=dbSNP:rs36049074,PMID:5792729 P69892 UniProtKB Natural variant 119 119 . . . ID=VAR_015740;Note=In Calabria. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10722114;Dbxref=dbSNP:rs35020253,PMID:10722114 P69892 UniProtKB Natural variant 121 121 . . . ID=VAR_003172;Note=In Caltech. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6186635;Dbxref=dbSNP:rs34703519,PMID:6186635 P69892 UniProtKB Natural variant 122 122 . . . ID=VAR_020653;Note=In Carlton. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:836882;Dbxref=dbSNP:rs63750021,PMID:836882 P69892 UniProtKB Natural variant 126 126 . . . ID=VAR_003174;Note=In Port-Royal. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:4846278;Dbxref=dbSNP:rs34997902,PMID:4846278 P69892 UniProtKB Natural variant 131 131 . . . ID=VAR_003176;Note=In Poole%3B unstable. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1127124;Dbxref=dbSNP:rs35826780,PMID:1127124 P69892 UniProtKB Natural variant 147 147 . . . ID=VAR_003179;Note=In Onoda%3B O(2) affinity up. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1703139;Dbxref=dbSNP:rs34807671,PMID:1703139 P69892 UniProtKB Helix 6 17 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 21 35 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 37 46 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 52 56 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 59 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 76 81 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 82 95 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 102 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 120 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4 P69892 UniProtKB Helix 125 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QU4