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Protein

Nodal modulator 3

Gene

NOMO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May antagonize Nodal signaling.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 3
Alternative name(s):
pM5 protein 3
Gene namesi
Name:NOMO3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25242. NOMO3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 11551124ExtracellularSequence analysisAdd
BLAST
Transmembranei1156 – 117621HelicalSequence analysisAdd
BLAST
Topological domaini1177 – 122246CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950400.

Polymorphism and mutation databases

BioMutaiNOMO3.
DMDMi296439242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 12221191Nodal modulator 3PRO_0000021821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis
Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence analysis
Modified residuei1205 – 12051PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP69849.
PaxDbiP69849.
PeptideAtlasiP69849.
PRIDEiP69849.

PTM databases

iPTMnetiP69849.
PhosphoSiteiP69849.
SwissPalmiP69849.

Expressioni

Gene expression databases

BgeeiENSG00000103226.
CleanExiHS_NOMO3.
ExpressionAtlasiP69849. baseline and differential.
GenevisibleiP69849. HS.

Organism-specific databases

HPAiHPA046697.
HPA047245.
HPA061174.

Interactioni

Protein-protein interaction databases

BioGridi135912. 8 interactions.
IntActiP69849. 3 interactions.
MINTiMINT-2879695.
STRINGi9606.ENSP00000382274.

Structurei

3D structure databases

ProteinModelPortaliP69849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiP69849.
PhylomeDBiP69849.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIVATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKANPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTD RPVMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA
1210 1220
ASDNSGPEDA KRQAKKQKTR RT
Length:1,222
Mass (Da):134,134
Last modified:May 18, 2010 - v2
Checksum:i2142BE9860A76722
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti726 – 7261N → K in AAC15783 (PubMed:10493829).Curated
Sequence conflicti1141 – 11411I → F in AAC15783 (PubMed:10493829).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136624 Genomic DNA. No translation available.
U91318 Genomic DNA. Translation: AAC15783.1.
CCDSiCCDS42123.1.
RefSeqiNP_001004067.1. NM_001004067.3.
UniGeneiHs.460141.
Hs.743963.

Genome annotation databases

EnsembliENST00000399336; ENSP00000382274; ENSG00000103226.
ENST00000611106; ENSP00000483234; ENSG00000278087.
GeneIDi408050.
KEGGihsa:408050.
UCSCiuc002deq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136624 Genomic DNA. No translation available.
U91318 Genomic DNA. Translation: AAC15783.1.
CCDSiCCDS42123.1.
RefSeqiNP_001004067.1. NM_001004067.3.
UniGeneiHs.460141.
Hs.743963.

3D structure databases

ProteinModelPortaliP69849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135912. 8 interactions.
IntActiP69849. 3 interactions.
MINTiMINT-2879695.
STRINGi9606.ENSP00000382274.

PTM databases

iPTMnetiP69849.
PhosphoSiteiP69849.
SwissPalmiP69849.

Polymorphism and mutation databases

BioMutaiNOMO3.
DMDMi296439242.

Proteomic databases

MaxQBiP69849.
PaxDbiP69849.
PeptideAtlasiP69849.
PRIDEiP69849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399336; ENSP00000382274; ENSG00000103226.
ENST00000611106; ENSP00000483234; ENSG00000278087.
GeneIDi408050.
KEGGihsa:408050.
UCSCiuc002deq.4. human.

Organism-specific databases

CTDi408050.
GeneCardsiNOMO3.
H-InvDBHIX0202298.
HGNCiHGNC:25242. NOMO3.
HPAiHPA046697.
HPA047245.
HPA061174.
MIMi609159. gene.
neXtProtiNX_P69849.
PharmGKBiPA134950400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiP69849.
PhylomeDBiP69849.
TreeFamiTF313696.

Miscellaneous databases

GenomeRNAii408050.
PROiP69849.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103226.
CleanExiHS_NOMO3.
ExpressionAtlasiP69849. baseline and differential.
GenevisibleiP69849. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOMO3_HUMAN
AccessioniPrimary (citable) accession number: P69849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q5JPE7), NOMO2 (AC Q5JPE7) and NOMO3. All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.