Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PTS system galactitol-specific EIIC component

Gene

gatC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport.1 Publication

GO - Molecular functioni

GO - Biological processi

  • galactitol metabolic process Source: UniProtKB-KW
  • galactitol transport Source: EcoCyc
  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Galactitol metabolism, Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GATC-MONOMER.
ECOL316407:JW2076-MONOMER.
MetaCyc:GATC-MONOMER.

Protein family/group databases

TCDBi4.A.5.1.1. the pts galactitol (gat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system galactitol-specific EIIC component1 Publication
Alternative name(s):
EIIC-Gat1 Publication
Galactitol permease IIC component1 Publication
Gene namesi
Name:gatC
Ordered Locus Names:b2092, JW2076
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12416. gatC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei41 – 61HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei92 – 112HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei138 – 158HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei218 – 238HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei305 – 325HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei329 – 349HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei357 – 377HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei392 – 412HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei415 – 435HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001865701 – 451PTS system galactitol-specific EIIC componentAdd BLAST451

Proteomic databases

PaxDbiP69831.

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Subunit structurei

Forms a complex with one each of subunit of GatA, GatB and 2 subunits of GatC.1 Publication

Protein-protein interaction databases

BioGridi4260430. 3 interactors.
STRINGi511145.b2092.

Structurei

3D structure databases

ProteinModelPortaliP69831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 435PTS EIIC type-2PROSITE-ProRule annotationAdd BLAST430

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DT3. Bacteria.
COG3775. LUCA.
HOGENOMiHOG000053574.
InParanoidiP69831.
KOiK02775.
OMAiGFYVANA.
PhylomeDBiP69831.

Family and domain databases

InterProiIPR013853. GatC.
IPR013014. PTS_EIIC_2.
IPR004703. PTS_sugar-sp_permease.
[Graphical view]
PfamiPF03611. EIIC-GAT. 1 hit.
[Graphical view]
PIRSFiPIRSF006304. GatC. 1 hit.
TIGRFAMsiTIGR00827. EIIC-GAT. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSEVMRYIL DLGPTVMLPI VIIIFSKILG MKAGDCFKAG LHIGIGFVGI
60 70 80 90 100
GLVIGLMLDS IGPAAKAMAE NFDLNLHVVD VGWPGSSPMT WASQIALVAI
110 120 130 140 150
PIAILVNVAM LLTRMTRVVN VDIWNIWHMT FTGALLHLAT GSWMIGMAGV
160 170 180 190 200
VIHAAFVYKL GDWFARDTRN FFELEGIAIP HGTSAYMGPI AVLVDAIIEK
210 220 230 240 250
IPGVNRIKFS ADDIQRKFGP FGEPVTVGFV MGLIIGILAG YDVKGVLQLA
260 270 280 290 300
VKTAAVMLLM PRVIKPIMDG LTPIAKQARS RLQAKFGGQE FLIGLDPALL
310 320 330 340 350
LGHTAVVSAS LIFIPLTILI AVCVPGNQVL PFGDLATIGF FVAMAVAVHR
360 370 380 390 400
GNLFRTLISG VIIMSITLWI ATQTIGLHTQ LAANAGALKA GGMVASMDQG
410 420 430 440 450
GSPITWLLIQ VFSPQNIPGF IIIGAIYLTG IFMTWRRARG FIKQEKVVLA

E
Length:451
Mass (Da):48,365
Last modified:May 10, 2005 - v1
Checksum:iB843BB6BDE721F13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187 – 203MGPIA…EKIPG → LGPNCGAGGCYHRENPS in CAA56230 (PubMed:7772602).CuratedAdd BLAST17
Sequence conflicti399 – 451QGGSP…VVLAE → TGRFSHYLVTDSGFSPQIFP VSLLSAQFI in CAA56230 (PubMed:7772602).CuratedAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79837 Genomic DNA. Translation: CAA56230.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA15955.1.
PIRiC64976.
S55905.
RefSeqiWP_000490679.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiBAA15955; BAA15955; BAA15955.
KEGGiecj:JW2076.
PATRICi32119517. VBIEscCol129921_2169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79837 Genomic DNA. Translation: CAA56230.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA15955.1.
PIRiC64976.
S55905.
RefSeqiWP_000490679.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP69831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260430. 3 interactors.
STRINGi511145.b2092.

Protein family/group databases

TCDBi4.A.5.1.1. the pts galactitol (gat) family.

Proteomic databases

PaxDbiP69831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA15955; BAA15955; BAA15955.
KEGGiecj:JW2076.
PATRICi32119517. VBIEscCol129921_2169.

Organism-specific databases

EchoBASEiEB2315.
EcoGeneiEG12416. gatC.

Phylogenomic databases

eggNOGiENOG4105DT3. Bacteria.
COG3775. LUCA.
HOGENOMiHOG000053574.
InParanoidiP69831.
KOiK02775.
OMAiGFYVANA.
PhylomeDBiP69831.

Enzyme and pathway databases

BioCyciEcoCyc:GATC-MONOMER.
ECOL316407:JW2076-MONOMER.
MetaCyc:GATC-MONOMER.

Miscellaneous databases

PROiP69831.

Family and domain databases

InterProiIPR013853. GatC.
IPR013014. PTS_EIIC_2.
IPR004703. PTS_sugar-sp_permease.
[Graphical view]
PfamiPF03611. EIIC-GAT. 1 hit.
[Graphical view]
PIRSFiPIRSF006304. GatC. 1 hit.
TIGRFAMsiTIGR00827. EIIC-GAT. 1 hit.
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTKC_ECOLI
AccessioniPrimary (citable) accession number: P69831
Secondary accession number(s): P37189, P76411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

A pseudogene in strain MG1655 / ATCC 700926 due to a recent laboratory-derived single nucleotide insertion, but not its parent MG1655 / ATCC 47076.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.