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Protein

Mannitol-specific cryptic phosphotransferase enzyme IIA component

Gene

cmtB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Tele-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CMTB-MONOMER
MetaCyc:CMTB-MONOMER

Protein family/group databases

TCDBi4.A.2.1.24 the pts fructose-mannitol (fru) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol-specific cryptic phosphotransferase enzyme IIA component1 Publication
Alternative name(s):
EIIA-MtlBy similarity
EIII-MtlBy similarity
PTS system mannitol-specific EIIA componentBy similarity
Gene namesi
Name:cmtB
Ordered Locus Names:b2934, JW2901
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11791 cmtB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866811 – 147Mannitol-specific cryptic phosphotransferase enzyme IIA componentAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Phosphohistidine; by HPr1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP69824
PRIDEiP69824

PTM databases

iPTMnetiP69824

Interactioni

Protein-protein interaction databases

BioGridi4261871, 15 interactors
IntActiP69824, 2 interactors
STRINGi316407.85675744

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi12 – 16Combined sources5
Helixi21 – 27Combined sources7
Helixi30 – 33Combined sources4
Turni34 – 36Combined sources3
Helixi40 – 52Combined sources13
Beta strandi58 – 60Combined sources3
Helixi70 – 72Combined sources3
Beta strandi78 – 88Combined sources11
Beta strandi97 – 104Combined sources8
Helixi108 – 122Combined sources15
Helixi125 – 132Combined sources8
Helixi137 – 145Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OQ3NMR-A1-147[»]
ProteinModelPortaliP69824
SMRiP69824
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69824

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 147PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST143

Domaini

The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108X7Y Bacteria
COG1762 LUCA
HOGENOMiHOG000227560
KOiK02798
OMAiVINDRAY
PhylomeDBiP69824

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

P69824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSDYFPES SISVIHSAKD WQEAIDFSMV SLLDKNYISE NYIQAIKDST
60 70 80 90 100
INNGPYYILA PGVAMPHARP ECGALKTGMS LTLLEQGVYF PGNDEPIKLL
110 120 130 140
IGLSAADADS HIGAIQALSE LLCEEEILEQ LLTASSEKQL ADIISRG
Length:147
Mass (Da):16,046
Last modified:May 10, 2005 - v1
Checksum:i4E09A4E6D88D9190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72677 Genomic DNA Translation: CAA51228.1
U28377 Genomic DNA Translation: AAA69101.1
U00096 Genomic DNA Translation: AAC75971.1
AP009048 Genomic DNA Translation: BAE76997.1
PIRiS36122
RefSeqiNP_417409.1, NC_000913.3
WP_001239650.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75971; AAC75971; b2934
BAE76997; BAE76997; BAE76997
GeneIDi945125
KEGGiecj:JW2901
eco:b2934
PATRICifig|1411691.4.peg.3799

Similar proteinsi

Entry informationi

Entry nameiPTMA_ECOLI
AccessioniPrimary (citable) accession number: P69824
Secondary accession number(s): P32058, Q2M9Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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