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P69810 (PTFB1_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-like phosphotransferase enzyme IIB component 1
EC=2.7.1.69
Alternative name(s):
PTS system fructose-like EIIB component 1
Gene names
Name:fryB
Ordered Locus Names:Z3653, ECs3267
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane By similarity.

Catalytic activity

Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.

Subcellular location

Cytoplasm Potential.

Domain

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

Sequence similarities

Contains 1 PTS EIIB type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 108108Fructose-like phosphotransferase enzyme IIB component 1
PRO_0000186702

Regions

Domain1 – 104104PTS EIIB type-2

Sites

Active site111Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P69810 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: EADDEFB237FB72A9

FASTA10811,735
        10         20         30         40         50         60 
MSKKLIALCA CPMGLAHTFM AAQALEEAAV EAGYEVKIET QGADGIQNRL TAQDIAEATI 

        70         80         90        100 
IIHSVAVTPE DNERFESRDV YEITLQDAIK NAAGIIKEIE EMIASEQQ

« Hide

References

[1]"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7."
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. expand/collapse author list , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.
Nature 409:529-533(2001) [PubMed: 11206551] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
[2]"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. expand/collapse author list , Kuhara S., Shiba T., Hattori M., Shinagawa H.
DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG57513.1.
BA000007 Genomic DNA. Translation: BAB36690.1.
PIRC91037.
E85881.
RefSeqNP_288957.1. NC_002655.2.
NP_311294.1. NC_002695.1.

3D structure databases

ProteinModelPortalP69810.
SMRP69810. Positions 1-108.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000025413; EBESCP00000024306; EBESCG00000024467.
EBESCT00000057017; EBESCP00000054845; EBESCG00000056065.
GeneID915630.
959383.
GenomeReviewsGene locus Z3653 in contig AE005174_GR.
Gene locus ECs3267 in contig BA000007_GR.
KEGGece:Z3653.
ecs:ECs3267.
PATRIC18355934. VBIEscCol44059_3167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000031719.
HOGENOMHBG564028.
OMAAVCACPM.
ProtClustDBCLSK880379.

Enzyme and pathway databases

BioCycECOL83334:ECS3267-MONOMER.

Family and domain databases

InterProIPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
IPR003353. PTS_IIB_fruc.
[Graphical view]
KOK11202.
PfamPF02302. PTS_IIB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00829. FRU. 1 hit.
PROSITEPS51099. PTS_EIIB_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTFB1_ECO57
AccessionPrimary (citable) accession number: P69810
Secondary accession number(s): P76525, P78264
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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