P69808 (PTFB1_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fructose-like phosphotransferase enzyme IIB component 1 EC=2.7.1.69 Alternative name(s): PTS system fructose-like EIIB component 1 | ||||||
| Gene names |
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| Organism | Escherichia coli (strain K12) | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 108 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane By similarity. |
| Catalytic activity | Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate. |
| Subcellular location | Cytoplasm Potential. |
| Domain | The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. |
| Sequence similarities | Contains 1 PTS EIIB type-2 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phosphotransferase system Sugar transport Transport |
| Cellular component | Cytoplasm |
| Molecular function | Kinase Transferase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein-N(PI)-phosphohistidine-sugar phosphotransferase activityInferred from electronic annotation. Source: EC sugar:hydrogen symporter activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 108 | 108 | Fructose-like phosphotransferase enzyme IIB component 1 | PRO_0000186700 | |||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||
| Domain | 1 – 104 | 104 | PTS EIIB type-2 | ||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||
| Active site | 11 | 1 | Phosphocysteine intermediate By similarity | ||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Beta strand | 4 – 10 | 7 | |||||||||||||||||||||||||
| Helix | 16 – 31 | 16 | |||||||||||||||||||||||||
| Beta strand | 35 – 42 | 8 | |||||||||||||||||||||||||
| Helix | 52 – 57 | 6 | |||||||||||||||||||||||||
| Beta strand | 59 – 67 | 9 | |||||||||||||||||||||||||
| Helix | 72 – 75 | 4 | |||||||||||||||||||||||||
| Beta strand | 80 – 84 | 5 | |||||||||||||||||||||||||
| Helix | 87 – 90 | 4 | |||||||||||||||||||||||||
| Helix | 96 – 107 | 12 | |||||||||||||||||||||||||
Sequences
References
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U00096 Genomic DNA. Translation: AAC75446.1. AP009048 Genomic DNA. Translation: BAA16257.2. | ||||||||||||
| PIR | H65012. | ||||||||||||
| RefSeq | NP_416888.1. NC_000913.2. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P69808. | ||||||||||||
| SMR | P69808. Positions 1-108. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein family/group databases | |||||||||||||
| TCDB | 4.A.2.1.11. PTS fructose-mannitol (Fru) family. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| EnsemblBacteria | EBESCT00000004424; EBESCP00000004424; EBESCG00000003611. EBESCT00000016643; EBESCP00000015934; EBESCG00000015702. | ||||||||||||
| GeneID | 949087. | ||||||||||||
| GenomeReviews | Gene locus JW5389 in contig AP009048_GR. Gene locus b2387 in contig U00096_GR. | ||||||||||||
| KEGG | ecj:JW5389. eco:b2387. | ||||||||||||
| PATRIC | 32120153. VBIEscCol129921_2485. | ||||||||||||
Organism-specific databases | |||||||||||||
| EchoBASE | EB3907. | ||||||||||||
| EcoGene | EG14155. fryB. | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG1445. | ||||||||||||
| GeneTree | EBGT00070000031719. | ||||||||||||
| HOGENOM | HBG564028. | ||||||||||||
| OMA | AVCACPM. | ||||||||||||
| PhylomeDB | P69808. | ||||||||||||
| ProtClustDB | CLSK880379. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | EcoCyc:G7250-MONOMER. | ||||||||||||
Gene expression databases | |||||||||||||
| Genevestigator | P69808. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR013011. PTS_EIIB_2. IPR003501. PTS_EIIB_2/3. IPR003353. PTS_IIB_fruc. [Graphical view] | ||||||||||||
| KO | K11202. | ||||||||||||
| Pfam | PF02302. PTS_IIB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00829. FRU. 1 hit. | ||||||||||||
| PROSITE | PS51099. PTS_EIIB_TYPE_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | PTFB1_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P69808 Secondary accession number(s): P76525, P78264 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with