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Protein

PTS system mannose-specific EIIC component

Gene

manY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed:2951378, PubMed:2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed:2951378, PubMed:2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed:4604906, PubMed:353494).4 Publications

GO - Molecular functioni

GO - Biological processi

  • glucose import into cell Source: EcoCyc
  • mannose transport Source: EcoCyc
  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MANY-MONOMER.
ECOL316407:JW1807-MONOMER.
MetaCyc:MANY-MONOMER.

Protein family/group databases

TCDBi4.A.6.1.1. the pts mannose-fructose-sorbose (man) family.

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system mannose-specific EIIC component1 Publication
Alternative name(s):
EII-P-Man1 Publication
EIIC-Man1 Publication
Mannose permease IIC component1 Publication
Gene namesi
Name:manY
Synonyms:pel, ptsP
Ordered Locus Names:b1818, JW1807
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10568. manY.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4Cytoplasmic1 Publication4
Transmembranei5 – 24Helical1 PublicationAdd BLAST20
Topological domaini25 – 49Periplasmic1 PublicationAdd BLAST25
Transmembranei50 – 69Helical1 PublicationAdd BLAST20
Topological domaini70 – 83Cytoplasmic1 PublicationAdd BLAST14
Transmembranei84 – 102Helical1 PublicationAdd BLAST19
Topological domaini103 – 105Periplasmic1 Publication3
Transmembranei106 – 124Helical1 PublicationAdd BLAST19
Topological domaini125 – 150Cytoplasmic1 PublicationAdd BLAST26
Transmembranei151 – 170Helical1 PublicationAdd BLAST20
Topological domaini171 – 181Periplasmic1 PublicationAdd BLAST11
Transmembranei182 – 201Helical1 PublicationAdd BLAST20
Topological domaini202 – 266Cytoplasmic1 PublicationAdd BLAST65

GO - Cellular componenti

  • integral component of plasma membrane Source: CACAO
  • membrane Source: UniProtKB
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866461 – 266PTS system mannose-specific EIIC componentAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP69801.
PRIDEiP69801.

Interactioni

Protein-protein interaction databases

BioGridi4259145. 469 interactors.
IntActiP69801. 1 interactor.
STRINGi511145.b1818.

Structurei

3D structure databases

ProteinModelPortaliP69801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 237PTS EIIC type-4PROSITE-ProRule annotationAdd BLAST235

Domaini

The PTS EIIC type-4 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 PTS EIIC type-4 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ETZ. Bacteria.
COG3715. LUCA.
HOGENOMiHOG000097554.
InParanoidiP69801.
KOiK02795.
OMAiACIAGMD.
PhylomeDBiP69801.

Family and domain databases

InterProiIPR004700. PTS_IIC_man.
[Graphical view]
PANTHERiPTHR32502:SF4. PTHR32502:SF4. 1 hit.
PfamiPF03609. EII-Sor. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00822. EII-Sor. 1 hit.
PROSITEiPS51106. PTS_EIIC_TYPE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITTLQIVL VFIVACIAGM GSILDEFQFH RPLIACTLVG IVLGDMKTGI
60 70 80 90 100
IIGGTLEMIA LGWMNIGAAV APDAALASII STILVIAGHQ SIGAGIALAI
110 120 130 140 150
PLAAAGQVLT IIVRTITVAF QHAADKAADN GNLTAISWIH VSSLFLQAMR
160 170 180 190 200
VAIPAVIVAL SVGTSEVQNM LNAIPEVVTN GLNIAGGMIV VVGYAMVINM
210 220 230 240 250
MRAGYLMPFF YLGFVTAAFT NFNLVALGVI GTVMAVLYIQ LSPKYNRVAG
260
APAQAAGNND LDNELD
Length:266
Mass (Da):27,636
Last modified:August 1, 1988 - v1
Checksum:iEAFDD9E4B809AF23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02699 Genomic DNA. Translation: AAA24444.1.
U00096 Genomic DNA. Translation: AAC74888.1.
AP009048 Genomic DNA. Translation: BAA15625.1.
M36404 Genomic DNA. Translation: AAA24111.1. Different termination.
PIRiA30285. WQECMP.
RefSeqiNP_416332.1. NC_000913.3.
WP_000406926.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74888; AAC74888; b1818.
BAA15625; BAA15625; BAA15625.
GeneIDi946332.
KEGGiecj:JW1807.
eco:b1818.
PATRICi32118955. VBIEscCol129921_1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02699 Genomic DNA. Translation: AAA24444.1.
U00096 Genomic DNA. Translation: AAC74888.1.
AP009048 Genomic DNA. Translation: BAA15625.1.
M36404 Genomic DNA. Translation: AAA24111.1. Different termination.
PIRiA30285. WQECMP.
RefSeqiNP_416332.1. NC_000913.3.
WP_000406926.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP69801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259145. 469 interactors.
IntActiP69801. 1 interactor.
STRINGi511145.b1818.

Protein family/group databases

TCDBi4.A.6.1.1. the pts mannose-fructose-sorbose (man) family.

Proteomic databases

PaxDbiP69801.
PRIDEiP69801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74888; AAC74888; b1818.
BAA15625; BAA15625; BAA15625.
GeneIDi946332.
KEGGiecj:JW1807.
eco:b1818.
PATRICi32118955. VBIEscCol129921_1895.

Organism-specific databases

EchoBASEiEB0563.
EcoGeneiEG10568. manY.

Phylogenomic databases

eggNOGiENOG4105ETZ. Bacteria.
COG3715. LUCA.
HOGENOMiHOG000097554.
InParanoidiP69801.
KOiK02795.
OMAiACIAGMD.
PhylomeDBiP69801.

Enzyme and pathway databases

BioCyciEcoCyc:MANY-MONOMER.
ECOL316407:JW1807-MONOMER.
MetaCyc:MANY-MONOMER.

Miscellaneous databases

PROiP69801.

Family and domain databases

InterProiIPR004700. PTS_IIC_man.
[Graphical view]
PANTHERiPTHR32502:SF4. PTHR32502:SF4. 1 hit.
PfamiPF03609. EII-Sor. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00822. EII-Sor. 1 hit.
PROSITEiPS51106. PTS_EIIC_TYPE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTNC_ECOLI
AccessioniPrimary (citable) accession number: P69801
Secondary accession number(s): P08187, Q47351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.