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Protein

Alpha-conotoxin OIVA

Gene
N/A
Organism
Conus obscurus (Obscure cone) (Conus halitropus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1/beta-1/gamma/delta subunits) (IC50=0.51 nM) with 600-fold greater affinity than the adult subtype (IC50=310 nM). It blocks the elicited currents completely and it dissociates very slowly from the fetal muscle receptor. This toxin causes an apparently irreversible paralysis upon intramuscular injection into gold fish.1 Publication

Miscellaneous

The cysteine framework differs from the previously characterized alpha-A conotoxins. It also differs in its disulfide bonding. It is why authors (PubMed:15246771) propose the novel nomenclature Alpha-A1-3 conotoxin OIVA.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin OIVA
Short name:
Alpha-A-O4a
Short name:
Alpha-A-OIVA
OrganismiConus obscurus (Obscure cone) (Conus halitropus)
Taxonomic identifieri89447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1397. OIVA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10H → P: Dissociates very rapidly from the fetal muscle receptor. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444671 – 18Alpha-conotoxin OIVAAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 91 Publication
Disulfide bondi2 ↔ 141 Publication
Modified residuei54-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi12 ↔ 181 Publication
Modified residuei18Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Sequencei

Sequence statusi: Complete.

P69746-1 [UniParc]FASTAAdd to basket

« Hide

        10 
CCGVPNAACH PCVCKNTC
Length:18
Mass (Da):1,823
Last modified:April 26, 2005 - v1
Checksum:i8D0E5A8667119C7E
GO

Mass spectrometryi

Molecular mass is 1848.58 Da from positions 1 - 18. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCA4A_CONOB
AccessioniPrimary (citable) accession number: P69746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 22, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families