P69712 (CAPSD_WHV3) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 31, 2011.
Version 34.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Capsid protein Alternative name(s): Core antigen Core protein HBcAg | ||
| Gene names |
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| Organism | Woodchuck hepatitis B virus (isolate 59) (WHV) [Complete proteome] | ||
| Taxonomic identifier | 10431 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus | ||
| Virus host | Marmota monax (Woodchuck) [TaxID: 9995] |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions By similarity. |
| Subunit structure | Homodimerizes, then multimerizes By similarity. |
| Subcellular location | Capsid protein: Virion. Host cytoplasm By similarity. |
| Sequence similarities | Belongs to the orthohepadnavirus core antigen family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform Capsid protein (identifier: P69712-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform External core antigen (identifier: P0C6J4-1) The sequence of this isoform can be found in the external entry P0C6J4. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Capsid protein | PRO_0000222326 | |||||
Regions | |||||||||
| Repeat | 160 – 166 | 7 | 1; half-length | ||||||
| Repeat | 167 – 174 | 8 | 2 | ||||||
| Repeat | 175 – 182 | 8 | 3 | ||||||
| Region | 160 – 182 | 23 | 3 X 8 AA repeats of S-P-R-R-R-[PR]-S-Q | ||||||
| Region | 182 – 188 | 7 | RNA binding By similarity | ||||||
| Motif | 163 – 180 | 18 | Bipartite nuclear localization signal Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 160 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 167 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 175 | 1 | Phosphoserine; by host By similarity | ||||||
Sequences
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References
| [1] | "Sequence comparison of woodchuck hepatitis virus replicative forms shows conservation of the genome." Cohen J.I., Miller R.H., Rosenblum B., Denniston K., Gerin J.L., Purcell R.H. Virology 162:12-20(1988) [PubMed: 3336938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M19183 Genomic DNA. Translation: AAA46765.1. |
| PIR | NKVLC. C32397. |
| RefSeq | NP_671816.1. NC_004107.1. |
3D structure databases | |
| ProteinModelPortal | P69712. |
| SMR | P69712. Positions 1-143. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2546420. |
Family and domain databases | |
| InterPro | IPR002006. Viral_capsid_core_Hepatitis. [Graphical view] |
| Pfam | PF00906. Hepatitis_core. 1 hit. [Graphical view] |
| SUPFAM | SSF47852. Viral_capsid_core_Hepatitis. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CAPSD_WHV3 | ||||||||
| Accession | Primary (citable) accession number: P69712 Secondary accession number(s): P03152 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |