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P69687

- CAPSD_TMV

UniProt

P69687 - CAPSD_TMV

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Protein

Capsid protein

Gene

CP

Organism
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Gene namesi
Name:CP
OrganismiTobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))
Taxonomic identifieri12243 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageVirgaviridaeTobamovirus
Virus hostiNicotiana tabacum (Common tobacco) [TaxID: 4097]
ProteomesiUP000000522: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by host2 Publications
Chaini2 – 159158Capsid proteinPRO_0000144918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine; by host

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

DIPiDIP-59677N.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Helixi8 – 125Combined sources
Helixi21 – 3111Combined sources
Helixi39 – 5113Combined sources
Beta strandi69 – 713Combined sources
Helixi77 – 8711Combined sources
Helixi107 – 13529Combined sources
Turni136 – 1383Combined sources
Helixi142 – 1498Combined sources
Beta strandi152 – 1543Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EI7X-ray2.45A/B2-159[»]
2TMVfiber diffraction2.90P2-159[»]
3J06electron microscopy-A1-159[»]
3KMLX-ray3.01A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q2-100[»]
4GQHX-ray3.06A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/h/i2-155[»]
ProteinModelPortaliP69687.
SMRiP69687. Positions 2-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69687.

Family & Domainsi

Sequence similaritiesi

Belongs to the virgaviridae capsid protein family.Curated

Family and domain databases

Gene3Di1.20.120.70. 1 hit.
InterProiIPR001337. TMV-like_coat.
[Graphical view]
PfamiPF00721. TMV_coat. 1 hit.
[Graphical view]
SUPFAMiSSF47195. SSF47195. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYSITTPSQ FVFLSSAWAD PIELINLCTN ALGNQFQTQQ ARTVVQRQFS
60 70 80 90 100
EVWKPSPQVT VRFPDSDFKV YRYNAVLDPL VTALLGAFDT RNRIIEVENQ
110 120 130 140 150
ANPTTAETLD ATRRVDDATV AIRSAINNLI VELIRGTGSY NRSSFESSSG

LVWTSGPAT
Length:159
Mass (Da):17,624
Last modified:January 23, 2007 - v2
Checksum:i5C90E8478A43DBC4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291T → I in PM2; DT1 and DT2.
Natural varianti79 – 791P → S in DT2.
Natural varianti96 – 961E → D in PM2; DT1 and DT2.
Natural varianti104 – 1041T → M in PM2.
Natural varianti138 – 1381G → R in DT1 and DT2.
Natural varianti149 – 1491S → Y in DT2.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01408 Unassigned RNA. No translation available.
V01409 Genomic RNA. No translation available.
V01406 Genomic RNA. Translation: CAA24685.1.
X70882 mRNA. Translation: CAA50227.1.
X70883 mRNA. Translation: CAA50228.1.
X70884 mRNA. Translation: CAA50229.1.
RefSeqiNP_597750.1. NC_001367.1.

Genome annotation databases

GeneIDi1494080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01408 Unassigned RNA. No translation available.
V01409 Genomic RNA. No translation available.
V01406 Genomic RNA. Translation: CAA24685.1 .
X70882 mRNA. Translation: CAA50227.1 .
X70883 mRNA. Translation: CAA50228.1 .
X70884 mRNA. Translation: CAA50229.1 .
RefSeqi NP_597750.1. NC_001367.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EI7 X-ray 2.45 A/B 2-159 [» ]
2TMV fiber diffraction 2.90 P 2-159 [» ]
3J06 electron microscopy - A 1-159 [» ]
3KML X-ray 3.01 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q 2-100 [» ]
4GQH X-ray 3.06 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/h/i 2-155 [» ]
ProteinModelPortali P69687.
SMRi P69687. Positions 2-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59677N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1494080.

Miscellaneous databases

EvolutionaryTracei P69687.

Family and domain databases

Gene3Di 1.20.120.70. 1 hit.
InterProi IPR001337. TMV-like_coat.
[Graphical view ]
Pfami PF00721. TMV_coat. 1 hit.
[Graphical view ]
SUPFAMi SSF47195. SSF47195. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Sequence of 1000 nucleotides at the 3' end of tobacco mosaic virus RNA."
    Guilley H., Jonard G., Kukla B., Richards K.E.
    Nucleic Acids Res. 6:1287-1308(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-159.
  4. "Studies on the amino acid sequence of tobacco mosaic virus protein. V. Amino acid sequences of two peptides from tryptic digests and location of amide group."
    Funatsu G., Tsugita A., Fraenkel-Conrat H.
    Arch. Biochem. Biophys. 105:25-41(1964) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-42 AND 94-113, SEQUENCE REVISION.
  5. "The sequence of amino acids in the protein of tobacco mosaic virus. IV. Separation of tobacco mosaic virus protein with trypsin."
    Anderer F.A., Handschuh D.
    Z. Naturforsch. B 17:536-543(1962)
    Cited for: PROTEIN SEQUENCE OF 2-159.
  6. "Further studies on amino acid sequence of proteins in tobacco mosaic virus."
    Anderer F.A., Wittmann-Liebold B., Wittmann H.G.
    Z. Naturforsch. B 20:1203-1213(1965) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "Amino acid sequences of some common Japanese strains of tobacco mosaic virus."
    Nozu Y., Ohno T., Okada Y.
    J. Biochem. 68:39-52(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  8. "Capsid protein gene sequences of four tobacco mosaic virus strains defective for virus assembly."
    Kuhlmann U., Sarkar S., Rohde W.
    Nucleic Acids Res. 21:3325-3325(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTANTS DEFECTIVE CAPSID PM2; DT1 AND DT2.
  9. "Structure of tobacco mosaic virus at 3.6-A resolution: implications for assembly."
    Namba K., Stubbs G.
    Science 231:1401-1406(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 1-159.

Entry informationi

Entry nameiCAPSD_TMV
AccessioniPrimary (citable) accession number: P69687
Secondary accession number(s): P03570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3