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P69687

- CAPSD_TMV

UniProt

P69687 - CAPSD_TMV

Protein

Capsid protein

Gene

CP

Organism
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein
    Alternative name(s):
    Coat protein
    Gene namesi
    Name:CP
    OrganismiTobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1))
    Taxonomic identifieri12243 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageVirgaviridaeTobamovirus
    Virus hostiNicotiana tabacum (Common tobacco) [TaxID: 4097]
    ProteomesiUP000000522: Genome

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by host2 Publications
    Chaini2 – 159158Capsid proteinPRO_0000144918Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine; by host

    Keywords - PTMi

    Acetylation

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59677N.

    Structurei

    Secondary structure

    1
    159
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi8 – 125
    Helixi21 – 3111
    Helixi39 – 5113
    Beta strandi69 – 713
    Helixi77 – 8711
    Helixi107 – 13529
    Turni136 – 1383
    Helixi142 – 1498
    Beta strandi152 – 1543

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EI7X-ray2.45A/B2-159[»]
    2TMVfiber diffraction2.90P2-159[»]
    3J06electron microscopy-A1-159[»]
    3KMLX-ray3.01A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q2-100[»]
    4GQHX-ray3.06A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/h/i2-155[»]
    ProteinModelPortaliP69687.
    SMRiP69687. Positions 2-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP69687.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the virgaviridae capsid protein family.Curated

    Family and domain databases

    Gene3Di1.20.120.70. 1 hit.
    InterProiIPR001337. TMV-like_coat.
    [Graphical view]
    PfamiPF00721. TMV_coat. 1 hit.
    [Graphical view]
    SUPFAMiSSF47195. SSF47195. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P69687-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYSITTPSQ FVFLSSAWAD PIELINLCTN ALGNQFQTQQ ARTVVQRQFS    50
    EVWKPSPQVT VRFPDSDFKV YRYNAVLDPL VTALLGAFDT RNRIIEVENQ 100
    ANPTTAETLD ATRRVDDATV AIRSAINNLI VELIRGTGSY NRSSFESSSG 150
    LVWTSGPAT 159
    Length:159
    Mass (Da):17,624
    Last modified:January 23, 2007 - v2
    Checksum:i5C90E8478A43DBC4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291T → I in PM2; DT1 and DT2.
    Natural varianti79 – 791P → S in DT2.
    Natural varianti96 – 961E → D in PM2; DT1 and DT2.
    Natural varianti104 – 1041T → M in PM2.
    Natural varianti138 – 1381G → R in DT1 and DT2.
    Natural varianti149 – 1491S → Y in DT2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01408 Unassigned RNA. No translation available.
    V01409 Genomic RNA. No translation available.
    V01406 Genomic RNA. Translation: CAA24685.1.
    X70882 mRNA. Translation: CAA50227.1.
    X70883 mRNA. Translation: CAA50228.1.
    X70884 mRNA. Translation: CAA50229.1.
    RefSeqiNP_597750.1. NC_001367.1.

    Genome annotation databases

    GeneIDi1494080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01408 Unassigned RNA. No translation available.
    V01409 Genomic RNA. No translation available.
    V01406 Genomic RNA. Translation: CAA24685.1 .
    X70882 mRNA. Translation: CAA50227.1 .
    X70883 mRNA. Translation: CAA50228.1 .
    X70884 mRNA. Translation: CAA50229.1 .
    RefSeqi NP_597750.1. NC_001367.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EI7 X-ray 2.45 A/B 2-159 [» ]
    2TMV fiber diffraction 2.90 P 2-159 [» ]
    3J06 electron microscopy - A 1-159 [» ]
    3KML X-ray 3.01 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q 2-100 [» ]
    4GQH X-ray 3.06 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/h/i 2-155 [» ]
    ProteinModelPortali P69687.
    SMRi P69687. Positions 2-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59677N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1494080.

    Miscellaneous databases

    EvolutionaryTracei P69687.

    Family and domain databases

    Gene3Di 1.20.120.70. 1 hit.
    InterProi IPR001337. TMV-like_coat.
    [Graphical view ]
    Pfami PF00721. TMV_coat. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47195. SSF47195. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Sequence of 1000 nucleotides at the 3' end of tobacco mosaic virus RNA."
      Guilley H., Jonard G., Kukla B., Richards K.E.
      Nucleic Acids Res. 6:1287-1308(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-159.
    4. "Studies on the amino acid sequence of tobacco mosaic virus protein. V. Amino acid sequences of two peptides from tryptic digests and location of amide group."
      Funatsu G., Tsugita A., Fraenkel-Conrat H.
      Arch. Biochem. Biophys. 105:25-41(1964) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-42 AND 94-113, SEQUENCE REVISION.
    5. "The sequence of amino acids in the protein of tobacco mosaic virus. IV. Separation of tobacco mosaic virus protein with trypsin."
      Anderer F.A., Handschuh D.
      Z. Naturforsch. B 17:536-543(1962)
      Cited for: PROTEIN SEQUENCE OF 2-159.
    6. "Further studies on amino acid sequence of proteins in tobacco mosaic virus."
      Anderer F.A., Wittmann-Liebold B., Wittmann H.G.
      Z. Naturforsch. B 20:1203-1213(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    7. "Amino acid sequences of some common Japanese strains of tobacco mosaic virus."
      Nozu Y., Ohno T., Okada Y.
      J. Biochem. 68:39-52(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    8. "Capsid protein gene sequences of four tobacco mosaic virus strains defective for virus assembly."
      Kuhlmann U., Sarkar S., Rohde W.
      Nucleic Acids Res. 21:3325-3325(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTANTS DEFECTIVE CAPSID PM2; DT1 AND DT2.
    9. "Structure of tobacco mosaic virus at 3.6-A resolution: implications for assembly."
      Namba K., Stubbs G.
      Science 231:1401-1406(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 1-159.

    Entry informationi

    Entry nameiCAPSD_TMV
    AccessioniPrimary (citable) accession number: P69687
    Secondary accession number(s): P03570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3