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P69616 (ORF3_HEVBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a viral regulatory protein involved in the modulation of mitogenic signaling pathways. May be involved in virion morphogenesis and viral pathogenesis. Expedites the processing and secretion of AMBP from the hepatocyte By similarity.

Subunit structure

Homodimer. Interacts with host SRC, HCK, FYN, PIK3R3 and GRB2 (via SH3 domain); binding does not activate the kinases. Interacts with host AMBP/bikunin and AMBP/alpha-1-microglobulin peptides. Interacts with host HPX/hemopexin. The phosphorylated form interacts with the unglycosylated capsid protein By similarity.

Subcellular location

Host cytoplasm By similarity. Note: The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions By similarity.

Post-translational modification

Not glycosylated By similarity.

Sequence similarities

Belongs to the hepevirus ORF3 protein family.

Sequence caution

The sequence AAA45735.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentHost cytoplasm
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processvirus-host interaction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114Protein ORF3
PRO_0000100136

Regions

Region6 – 2217Hydrophobic
Region28 – 6841Interaction with host HPX By similarity
Region33 – 5321Hydrophobic
Region48 – 7225Interaction with the capsid protein By similarity
Region72 – 11443Homodimerization, and interaction with host AMBP/bikunin By similarity
Region95 – 10410Interaction with host SRC, HCK, FYN, PIK3R3 and GRB2 By similarity
Compositional bias6 – 2217Cys-rich
Compositional bias55 – 11258Pro-rich

Amino acid modifications

Modified residue711Phosphoserine; by host By similarity

Sequences

Sequence LengthMass (Da)Tools
P69616 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: C5AC40F482A1D7F6

FASTA11411,712
        10         20         30         40         50         60 
MGSRPCALGL FCCCSSCFCL CCPRHRPVSR LAAVVGGAAA VPAVVSGVTG LILSPSQSPI 

        70         80         90        100        110 
FIQPTPSPPM SPLRPGLDLV FANPPDHSAP LGVTRPSAPP LPHVVDLPQL GPRR

« Hide

References

[1]"Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome."
Tam A.W., Smith M.M., Guerra M.E., Huang C.-C., Bradley D.W., Fry K.E., Reyes G.R.
Virology 185:120-131(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M73218 Genomic RNA. Translation: AAA45735.1. Different initiation.
PIRVHWWHE. B40778.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZZQX-ray3.81A61-114[»]
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1366939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003384. HEV_Orf2.
[Graphical view]
PfamPF02444. HEV_ORF1. 1 hit.
[Graphical view]
ProDomPD006561. HEV_ORF2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameORF3_HEVBU
AccessionPrimary (citable) accession number: P69616
Secondary accession number(s): P29325
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 20, 2008
Last modified: April 3, 2013
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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