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P69566 (RANB9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ran-binding protein 9

Short name=RanBP9
Alternative name(s):
B-cell antigen receptor Ig beta-associated protein 1
Short name=IBAP-1
Ran-binding protein M
Short name=RanBPM
Gene names
Name:Ranbp9
Synonyms:Ranbpm
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation By similarity. Stabilizes TP73 isoform Alpha probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA By similarity.

Subunit structure

Interacts with GTP-bound Ran, AR, CDC2L1, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alphabut not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 By similarity. Interacts with NGFR and DDX4. Directly interacts with RANBP10 By similarity. Ref.1 Ref.4

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Perinuclear in spermatids. Ref.1

Tissue specificity

Ubiquitously expressed, with highest levels in maturating spermatocytes. Ref.1 Ref.5

Domain

The SPRY domain mediates the interaction with MET, AR, and CDC2L1 By similarity.

Post-translational modification

Phosphorylated in response to stress By similarity.

Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system By similarity.

Sequence similarities

Belongs to the RANBP9/10 family.

Contains 1 B30.2/SPRY domain.

Contains 1 CTLH domain.

Contains 1 LisH domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Lrp1bQ9JI182EBI-772305,EBI-8294317

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P69566-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P69566-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     108-115: NNLRVHYK → MWESSWVL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 653653Ran-binding protein 9
PRO_0000097170

Regions

Domain72 – 259188B30.2/SPRY
Domain290 – 32233LisH
Domain328 – 38558CTLH
Region326 – 3327Interaction with CALB1 By similarity
Region539 – 653115Interaction with FMR1 By similarity
Compositional bias5 – 106Poly-Pro
Compositional bias14 – 207Poly-Pro

Amino acid modifications

Modified residue3301N6-acetyllysine By similarity
Modified residue4121Phosphoserine By similarity

Natural variations

Alternative sequence1 – 107107Missing in isoform 2.
VSP_028266
Alternative sequence108 – 1158NNLRVHYK → MWESSWVL in isoform 2.
VSP_028267

Experimental info

Sequence conflict921R → P Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 29, 2005. Version 1.
Checksum: BE810E69B238BBD5

FASTA65371,012
        10         20         30         40         50         60 
MSGQPPPPPP QQQPPPPPPP ASAAAPATAP PGLAVGPGPA AGVPVPGLAA GSSAAAPFPH 

        70         80         90        100        110        120 
GDSALNEQEK ELQRRLKRLY PAVDEQETPL PRSWSPKDKF SYIGLSQNNL RVHYKGHGKT 

       130        140        150        160        170        180 
PKDAASVRAT HPIPAACGIY YFEVKIVSKG RDGYMGIGLS AQGVNMNRLP GWDKHSYGYH 

       190        200        210        220        230        240 
GDDGHSFCSS GTGQPYGPTF TTGDVIGCCV NLINNTCFYT KNGHSLGIAF TDLPPNLYPT 

       250        260        270        280        290        300 
VGLQTPGEVV DANFGQHPFV FDIEDYMREW RTKIQAQIDR FPIGDREGEW QTMIQKMVSS 

       310        320        330        340        350        360 
YLVHHGYCAT AEAFARSTDQ TVLEELASIK NRQRIQKLVL AGRMGEAIET TQQLYPSLLE 

       370        380        390        400        410        420 
RNPNLLFTLK VRQFIEMVNG TDSEVRCLGG RSPKSQDSYP VSPRPFSSPS MSPSHGMSIH 

       430        440        450        460        470        480 
SLAPGKSSTA HFSGFESCSN GVISNKAHQS YCHSKHQLSS LTVPELNSLN VSRSQQVNNF 

       490        500        510        520        530        540 
TSNDVDMETD HYSNGVGETS SNGFLNGSSK HDHEMEDCDT EMEVDCSQLR RQLCGGSQAA 

       550        560        570        580        590        600 
IERMIHFGRE LQAMSEQLRR ECGKNTANKK MLKDAFSLLA YSDPWNSPVG NQLDPIQREP 

       610        620        630        640        650 
VCSALNSAIL ETHNLPKQPP LALAMGQATQ CLGLMARSGV GSCAFATVED YLH 

« Hide

Isoform 2 [UniParc].

Checksum: 8B74E3D4F271875F
Show »

FASTA54660,086

References

« Hide 'large scale' references
[1]"Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein."
Shibata N., Tsunekawa N., Okamoto-Ito S., Akasu R., Tokumasu A., Noce T.
Mol. Reprod. Dev. 67:1-7(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DDX4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Testis.
[2]"B cell antigen receptor Ig beta associated protein."
Doi T., Watanabe T.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
[4]"RanBPM is a novel binding protein for p75NTR."
Bai D., Chen H., Huang B.-R.
Biochem. Biophys. Res. Commun. 309:552-557(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-653 (ISOFORM 1), INTERACTION WITH NGFR.
Tissue: Brain.
[5]"RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."
Denti S., Sirri A., Cheli A., Rogge L., Innamorati G., Putignano S., Fabbri M., Pardi R., Bianchi E.
J. Biol. Chem. 279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF006465 mRNA. Translation: AAD01272.1.
AK132714 mRNA. Translation: BAE21317.1.
PIRJC8013.
RefSeqNP_064314.2. NM_019930.2.
UniGeneMm.148781.

3D structure databases

ProteinModelPortalP69566.
SMRP69566. Positions 141-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208133. 2 interactions.
IntActP69566. 6 interactions.

PTM databases

PhosphoSiteP69566.

Proteomic databases

MaxQBP69566.
PaxDbP69566.
PRIDEP69566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID56705.
KEGGmmu:56705.

Organism-specific databases

CTD10048.
MGIMGI:1928741. Ranbp9.

Phylogenomic databases

eggNOGNOG316575.
HOGENOMHOG000008133.
HOVERGENHBG053444.
InParanoidP69566.
PhylomeDBP69566.

Gene expression databases

CleanExMM_RANBP9.
GenevestigatorP69566.

Family and domain databases

InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF10607. CLTH. 1 hit.
PF08513. LisH. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRANBP9. mouse.
NextBio313155.
PROP69566.
SOURCESearch...

Entry information

Entry nameRANB9_MOUSE
AccessionPrimary (citable) accession number: P69566
Secondary accession number(s): P84500, Q3V136
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot