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P69566

- RANB9_MOUSE

UniProt

P69566 - RANB9_MOUSE

Protein

Ran-binding protein 9

Gene

Ranbp9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation By similarity. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. Ran GTPase binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ran-binding protein 9
    Short name:
    RanBP9
    Alternative name(s):
    B-cell antigen receptor Ig beta-associated protein 1
    Short name:
    IBAP-1
    Ran-binding protein M
    Short name:
    RanBPM
    Gene namesi
    Name:Ranbp9
    Synonyms:Ranbpm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1928741. Ranbp9.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Perinuclear in spermatids.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 653653Ran-binding protein 9PRO_0000097170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei330 – 3301N6-acetyllysineBy similarity
    Modified residuei412 – 4121PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated in response to stress.By similarity
    Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP69566.
    PaxDbiP69566.
    PRIDEiP69566.

    PTM databases

    PhosphoSiteiP69566.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in maturating spermatocytes.2 Publications

    Gene expression databases

    CleanExiMM_RANBP9.
    GenevestigatoriP69566.

    Interactioni

    Subunit structurei

    Interacts with GTP-bound Ran, AR, CDC2L1, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 By similarity. Interacts with NGFR and DDX4. Directly interacts with RANBP10 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Lrp1bQ9JI182EBI-772305,EBI-8294317

    Protein-protein interaction databases

    BioGridi208133. 2 interactions.
    IntActiP69566. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP69566.
    SMRiP69566. Positions 141-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 259188B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST
    Domaini290 – 32233LisHPROSITE-ProRule annotationAdd
    BLAST
    Domaini328 – 38558CTLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni326 – 3327Interaction with CALB1By similarity
    Regioni539 – 653115Interaction with FMR1By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 106Poly-Pro
    Compositional biasi14 – 207Poly-Pro

    Domaini

    The SPRY domain mediates the interaction with MET, AR, and CDC2L1.By similarity

    Sequence similaritiesi

    Belongs to the RANBP9/10 family.Curated
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 CTLH domain.PROSITE-ProRule annotation
    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG316575.
    HOGENOMiHOG000008133.
    HOVERGENiHBG053444.
    InParanoidiP69566.
    PhylomeDBiP69566.

    Family and domain databases

    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013144. CRA_dom.
    IPR024964. CTLH/CRA.
    IPR006595. CTLH_C.
    IPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF10607. CLTH. 1 hit.
    PF08513. LisH. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00757. CRA. 1 hit.
    SM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P69566-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGQPPPPPP QQQPPPPPPP ASAAAPATAP PGLAVGPGPA AGVPVPGLAA    50
    GSSAAAPFPH GDSALNEQEK ELQRRLKRLY PAVDEQETPL PRSWSPKDKF 100
    SYIGLSQNNL RVHYKGHGKT PKDAASVRAT HPIPAACGIY YFEVKIVSKG 150
    RDGYMGIGLS AQGVNMNRLP GWDKHSYGYH GDDGHSFCSS GTGQPYGPTF 200
    TTGDVIGCCV NLINNTCFYT KNGHSLGIAF TDLPPNLYPT VGLQTPGEVV 250
    DANFGQHPFV FDIEDYMREW RTKIQAQIDR FPIGDREGEW QTMIQKMVSS 300
    YLVHHGYCAT AEAFARSTDQ TVLEELASIK NRQRIQKLVL AGRMGEAIET 350
    TQQLYPSLLE RNPNLLFTLK VRQFIEMVNG TDSEVRCLGG RSPKSQDSYP 400
    VSPRPFSSPS MSPSHGMSIH SLAPGKSSTA HFSGFESCSN GVISNKAHQS 450
    YCHSKHQLSS LTVPELNSLN VSRSQQVNNF TSNDVDMETD HYSNGVGETS 500
    SNGFLNGSSK HDHEMEDCDT EMEVDCSQLR RQLCGGSQAA IERMIHFGRE 550
    LQAMSEQLRR ECGKNTANKK MLKDAFSLLA YSDPWNSPVG NQLDPIQREP 600
    VCSALNSAIL ETHNLPKQPP LALAMGQATQ CLGLMARSGV GSCAFATVED 650
    YLH 653
    Length:653
    Mass (Da):71,012
    Last modified:March 29, 2005 - v1
    Checksum:iBE810E69B238BBD5
    GO
    Isoform 2 (identifier: P69566-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: Missing.
         108-115: NNLRVHYK → MWESSWVL

    Note: No experimental confirmation available.

    Show »
    Length:546
    Mass (Da):60,086
    Checksum:i8B74E3D4F271875F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921R → P(PubMed:12963025)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_028266Add
    BLAST
    Alternative sequencei108 – 1158NNLRVHYK → MWESSWVL in isoform 2. 1 PublicationVSP_028267

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006465 mRNA. Translation: AAD01272.1.
    AK132714 mRNA. Translation: BAE21317.1.
    PIRiJC8013.
    RefSeqiNP_064314.2. NM_019930.2.
    UniGeneiMm.148781.

    Genome annotation databases

    GeneIDi56705.
    KEGGimmu:56705.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006465 mRNA. Translation: AAD01272.1 .
    AK132714 mRNA. Translation: BAE21317.1 .
    PIRi JC8013.
    RefSeqi NP_064314.2. NM_019930.2.
    UniGenei Mm.148781.

    3D structure databases

    ProteinModelPortali P69566.
    SMRi P69566. Positions 141-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208133. 2 interactions.
    IntActi P69566. 6 interactions.

    PTM databases

    PhosphoSitei P69566.

    Proteomic databases

    MaxQBi P69566.
    PaxDbi P69566.
    PRIDEi P69566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 56705.
    KEGGi mmu:56705.

    Organism-specific databases

    CTDi 10048.
    MGIi MGI:1928741. Ranbp9.

    Phylogenomic databases

    eggNOGi NOG316575.
    HOGENOMi HOG000008133.
    HOVERGENi HBG053444.
    InParanoidi P69566.
    PhylomeDBi P69566.

    Miscellaneous databases

    ChiTaRSi RANBP9. mouse.
    NextBioi 313155.
    PROi P69566.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_RANBP9.
    Genevestigatori P69566.

    Family and domain databases

    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013144. CRA_dom.
    IPR024964. CTLH/CRA.
    IPR006595. CTLH_C.
    IPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF10607. CLTH. 1 hit.
    PF08513. LisH. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00757. CRA. 1 hit.
    SM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein."
      Shibata N., Tsunekawa N., Okamoto-Ito S., Akasu R., Tokumasu A., Noce T.
      Mol. Reprod. Dev. 67:1-7(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DDX4, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Testis.
    2. "B cell antigen receptor Ig beta associated protein."
      Doi T., Watanabe T.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-653 (ISOFORM 1), INTERACTION WITH NGFR.
      Tissue: Brain.
    5. "RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."
      Denti S., Sirri A., Cheli A., Rogge L., Innamorati G., Putignano S., Fabbri M., Pardi R., Bianchi E.
      J. Biol. Chem. 279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRANB9_MOUSE
    AccessioniPrimary (citable) accession number: P69566
    Secondary accession number(s): P84500, Q3V136
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3