ID   P19_TBSVK               Reviewed;         172 AA.
AC   P69517; P50627;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=RNA silencing suppressor p19;
DE   AltName: Full=19 kDa symptom severity modulator;
GN   ORFNames=ORF4;
OS   Tomato bushy stunt virus (strain Ja9) (TBSV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC   Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus;
OC   Tombusvirus lycopersici.
OX   NCBI_TaxID=70158;
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH   NCBI_TaxID=3749; Malus.
OH   NCBI_TaxID=3766; Pyrus (pears).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4111; Solanum melongena (Eggplant) (Aubergine).
OH   NCBI_TaxID=29777; Tolmiea menziesii.
OH   NCBI_TaxID=13305; Tulipa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   AGRICOLA=IND20581771;
RA   Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E.,
RA   Garcia-Arenal F.;
RT   "Different tomato bushy stunt virus strains cause disease outbreaks on
RT   solanaceous crops in Spain.";
RL   Phytopathology 86:535-542(1996).
CC   -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC       silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC       select siRNAs based on the length of the duplex region of the RNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC       {ECO:0000305}.
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DR   EMBL; Z68898; CAA93130.1; -; Genomic_RNA.
DR   PDB; 4J39; X-ray; 1.70 A; A=27-149.
DR   PDB; 4J5V; X-ray; 2.15 A; A=27-149.
DR   PDB; 4JGN; X-ray; 1.86 A; A=27-149.
DR   PDB; 4JK0; X-ray; 2.30 A; D=27-149.
DR   PDB; 4JNX; X-ray; 1.95 A; A/D=27-149.
DR   PDB; 4KNQ; X-ray; 1.82 A; A=27-149.
DR   PDB; 4KQ0; X-ray; 2.10 A; A/D=27-157.
DR   PDB; 4KTG; X-ray; 1.92 A; A=27-149.
DR   PDBsum; 4J39; -.
DR   PDBsum; 4J5V; -.
DR   PDBsum; 4JGN; -.
DR   PDBsum; 4JK0; -.
DR   PDBsum; 4JNX; -.
DR   PDBsum; 4KNQ; -.
DR   PDBsum; 4KQ0; -.
DR   PDBsum; 4KTG; -.
DR   SMR; P69517; -.
DR   GO; GO:0044423; C:virion component; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.180; RNA silencing suppressor P19; 1.
DR   InterPro; IPR004905; Tombusvirus_p19.
DR   InterPro; IPR036131; VP19_sf.
DR   Pfam; PF03220; Tombus_P19; 1.
DR   SUPFAM; SSF103145; Tombusvirus P19 core protein, VP19; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; RNA-binding;
KW   Suppressor of RNA silencing; Viral immunoevasion.
FT   CHAIN           1..172
FT                   /note="RNA silencing suppressor p19"
FT                   /id="PRO_0000222883"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          29..32
FT                   /evidence="ECO:0007829|PDB:4JK0"
FT   HELIX           39..48
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   TURN            52..54
FT                   /evidence="ECO:0007829|PDB:4JGN"
FT   STRAND          57..65
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   STRAND          68..75
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   HELIX           80..87
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   HELIX           92..100
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   STRAND          104..106
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   STRAND          109..116
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   STRAND          119..126
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   HELIX           127..129
FT                   /evidence="ECO:0007829|PDB:4J39"
FT   HELIX           130..146
FT                   /evidence="ECO:0007829|PDB:4J39"
SQ   SEQUENCE   172 AA;  19364 MW;  72D0100B5C90AB8B CRC64;
     MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN SNQDNPLGFK
     ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS RFFGFDQIGC TYSIRFRGVS
     ITVSGGSRTL QHLCEMAIRS KQELLQLAPI EVESNVSRGC PEGTQTFEKE GE
//