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P69517

- P19_TBSVK

UniProt

P69517 - P19_TBSVK

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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Tomato bushy stunt virus (strain Ja9) (TBSV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiTomato bushy stunt virus (strain Ja9) (TBSV)
Taxonomic identifieri70158 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]

Subcellular locationi

GO - Cellular componenti

  1. virion Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172RNA silencing suppressor p19PRO_0000222883Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

Secondary structure

1
172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 324Combined sources
Helixi39 – 4810Combined sources
Turni52 – 543Combined sources
Beta strandi57 – 659Combined sources
Beta strandi68 – 758Combined sources
Helixi80 – 878Combined sources
Helixi92 – 1009Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi119 – 1268Combined sources
Helixi127 – 1293Combined sources
Helixi130 – 14617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J39X-ray1.70A27-149[»]
4J5VX-ray2.15A27-149[»]
4JGNX-ray1.86A27-149[»]
4JK0X-ray2.30D27-149[»]
4JNXX-ray1.95A/D27-149[»]
4KNQX-ray1.82A27-149[»]
4KQ0X-ray2.10A/D27-157[»]
4KTGX-ray1.92A27-149[»]
ProteinModelPortaliP69517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

InterProiIPR004905. Tombusvirus_p19.
[Graphical view]
PfamiPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomiPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103145. SSF103145. 1 hit.

Sequencei

Sequence statusi: Complete.

P69517-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN
60 70 80 90 100
SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS
110 120 130 140 150
RFFGFDQIGC TYSIRFRGVS ITVSGGSRTL QHLCEMAIRS KQELLQLAPI
160 170
EVESNVSRGC PEGTQTFEKE GE
Length:172
Mass (Da):19,364
Last modified:March 15, 2005 - v1
Checksum:i72D0100B5C90AB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68898 Genomic RNA. Translation: CAA93130.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68898 Genomic RNA. Translation: CAA93130.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4J39 X-ray 1.70 A 27-149 [» ]
4J5V X-ray 2.15 A 27-149 [» ]
4JGN X-ray 1.86 A 27-149 [» ]
4JK0 X-ray 2.30 D 27-149 [» ]
4JNX X-ray 1.95 A/D 27-149 [» ]
4KNQ X-ray 1.82 A 27-149 [» ]
4KQ0 X-ray 2.10 A/D 27-157 [» ]
4KTG X-ray 1.92 A 27-149 [» ]
ProteinModelPortali P69517.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR004905. Tombusvirus_p19.
[Graphical view ]
Pfami PF03220. Tombus_P19. 1 hit.
[Graphical view ]
ProDomi PD005743. Tombus_P19. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF103145. SSF103145. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Different tomato bushy stunt virus strains cause disease outbreaks on solanaceous crops in Spain."
    Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E., Garcia-Arenal F.
    Phytopathology 86:535-542(1996)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiP19_TBSVK
AccessioniPrimary (citable) accession number: P69517
Secondary accession number(s): P50627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3