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P69517

- P19_TBSVK

UniProt

P69517 - P19_TBSVK

Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Tomato bushy stunt virus (strain Ja9) (TBSV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Suppressor of RNA silencing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA silencing suppressor p19
    Alternative name(s):
    19 kDa symptom severity modulator
    Gene namesi
    ORF Names:ORF4
    OrganismiTomato bushy stunt virus (strain Ja9) (TBSV)
    Taxonomic identifieri70158 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
    Malus [TaxID: 3749]
    Pyrus (pears) [TaxID: 3766]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
    Tolmiea menziesii [TaxID: 29777]
    Tulipa [TaxID: 13305]

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172RNA silencing suppressor p19PRO_0000222883Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    Secondary structure

    1
    172
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 324
    Helixi39 – 4810
    Turni52 – 543
    Beta strandi57 – 659
    Beta strandi68 – 758
    Helixi80 – 878
    Helixi92 – 1009
    Beta strandi104 – 1063
    Beta strandi109 – 1168
    Beta strandi119 – 1268
    Helixi127 – 1293
    Helixi130 – 14617

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J39X-ray1.70A27-149[»]
    4J5VX-ray2.15A27-149[»]
    4JGNX-ray1.86A27-149[»]
    4JK0X-ray2.30D27-149[»]
    4JNXX-ray1.95A/D27-149[»]
    4KNQX-ray1.82A27-149[»]
    4KQ0X-ray2.10A/D27-157[»]
    4KTGX-ray1.92A27-149[»]
    ProteinModelPortaliP69517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tombusvirus protein p19 family.Curated

    Family and domain databases

    InterProiIPR004905. Tombusvirus_p19.
    [Graphical view]
    PfamiPF03220. Tombus_P19. 1 hit.
    [Graphical view]
    ProDomiPD005743. Tombus_P19. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF103145. SSF103145. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P69517-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN    50
    SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS 100
    RFFGFDQIGC TYSIRFRGVS ITVSGGSRTL QHLCEMAIRS KQELLQLAPI 150
    EVESNVSRGC PEGTQTFEKE GE 172
    Length:172
    Mass (Da):19,364
    Last modified:March 15, 2005 - v1
    Checksum:i72D0100B5C90AB8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68898 Genomic RNA. Translation: CAA93130.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68898 Genomic RNA. Translation: CAA93130.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J39 X-ray 1.70 A 27-149 [» ]
    4J5V X-ray 2.15 A 27-149 [» ]
    4JGN X-ray 1.86 A 27-149 [» ]
    4JK0 X-ray 2.30 D 27-149 [» ]
    4JNX X-ray 1.95 A/D 27-149 [» ]
    4KNQ X-ray 1.82 A 27-149 [» ]
    4KQ0 X-ray 2.10 A/D 27-157 [» ]
    4KTG X-ray 1.92 A 27-149 [» ]
    ProteinModelPortali P69517.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR004905. Tombusvirus_p19.
    [Graphical view ]
    Pfami PF03220. Tombus_P19. 1 hit.
    [Graphical view ]
    ProDomi PD005743. Tombus_P19. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF103145. SSF103145. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Different tomato bushy stunt virus strains cause disease outbreaks on solanaceous crops in Spain."
      Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E., Garcia-Arenal F.
      Phytopathology 86:535-542(1996)
      [AGRICOLA] [Europe PMC]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiP19_TBSVK
    AccessioniPrimary (citable) accession number: P69517
    Secondary accession number(s): P50627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3