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Protein

Kappa-conotoxin-like 2

Gene
N/A
Organism
Conus vexillum (Flag cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like 2
OrganismiConus vexillum (Flag cone)
Taxonomic identifieri89431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1086. Vx11.2 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003512027 – 59Kappa-conotoxin-like 2Add BLAST33
PropeptideiPRO_000003512163 – 67By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 43By similarity
Disulfide bondi36 ↔ 48By similarity
Disulfide bondi42 ↔ 51By similarity
Disulfide bondi47 ↔ 55By similarity
Modified residuei59Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR020242. Conotoxin_I2-superfamily.
PfamiView protein in Pfam
PF17557. Conotoxin_I2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162. Conotoxin_I2-superfamily. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCDT
60
CRNVCHLRFG KRATFQE
Length:67
Mass (Da):7,691
Last modified:March 15, 2005 - v1
Checksum:i4A941F6CB446F62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ748255 mRNA. Translation: CAG38082.1.

Similar proteinsi

Entry informationi

Entry nameiCI22_CONVX
AccessioniPrimary (citable) accession number: P69501
Secondary accession number(s): Q59AA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 22, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families