P69496 (CI22_CONIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin Im11.2
Organism	Conus imperialis (Imperial cone)
Taxonomic identifier	35631 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	64 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The cysteine framework is XI (C-C-CC-CC-C-C).
Sequence similarities	Belongs to the conotoxin I2 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Toxin
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 57	31	Conotoxin Im11.2		PRO_0000035092
	Propeptide	61 – 64	4	By similarity		PRO_0000035093
Amino acid modifications
	Modified residue	57	1	Aspartic acid 1-amide By similarity
	Disulfide bond	27 ↔ 41		By similarity
	Disulfide bond	34 ↔ 46		By similarity
	Disulfide bond	40 ↔ 50		By similarity
	Disulfide bond	45 ↔ 54		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P69496 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: FF671127AEA3CEBB	FASTA	64	7,416
	10 20 30 40 50 60 MMFRLTSVSC FLLVIVCLNL VVLTNACRLE GSSCRRSYQC CHKSCCIREC KFPCRWDGKR ATFQ

References

[1]	"Novel conopeptides of the I-superfamily occur in several clades of cone snails." Kauferstein S., Huys I., Kuch U., Melaun C., Tytgat J., Mebs D. Toxicon 44:539-548(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ746185 mRNA. Translation: CAG34093.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	1394. Im11.2 precursor.
Family and domain databases
InterPro	IPR013141. Conotoxin-I_CS. IPR020242. Conotoxin_I2-superfamily. [Graphical view]
ProDom	PD267162. Conotoxin_I2-superfamily. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS60019. I_CONOTOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CI22_CONIM

Accession

Primary (citable) accession number: P69496
Secondary accession number(s): Q59AA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	October 3, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program