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Protein

Divalent-cation tolerance protein CutA

Gene

cutA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in resistance toward heavy metals.1 Publication

Cofactori

Cu cation1 PublicationNote: Binds 1 copper ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16CopperCurated1
Metal bindingi83CopperCurated1
Metal bindingi84CopperCurated1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • metal ion binding Source: EcoCyc

GO - Biological processi

  • protein homooligomerization Source: UniProtKB
  • response to copper ion Source: EcoCyc

Keywordsi

LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12177-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Divalent-cation tolerance protein CutA
Alternative name(s):
C-type cytochrome biogenesis protein CycY
Gene namesi
Name:cutA
Synonyms:cutA1, cycY
Ordered Locus Names:b4137, JW4097
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12177 cutA

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB03975 Mercuribenzoic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571181 – 112Divalent-cation tolerance protein CutAAdd BLAST112

Proteomic databases

EPDiP69488
PaxDbiP69488
PRIDEiP69488

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi4262693, 8 interactors
DIPiDIP-47984N
IntActiP69488, 10 interactors
STRINGi316385.ECDH10B_4330

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 6Combined sources3
Beta strandi11 – 20Combined sources10
Helixi21 – 33Combined sources13
Beta strandi38 – 52Combined sources15
Beta strandi55 – 69Combined sources15
Helixi70 – 72Combined sources3
Helixi73 – 83Combined sources11
Beta strandi85 – 88Combined sources4
Beta strandi91 – 95Combined sources5
Helixi101 – 110Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NAQX-ray1.70A/B/C/D/E/F1-112[»]
3AA8X-ray2.30A/B/C1-112[»]
3AA9X-ray2.30A/B/C1-112[»]
3AH6X-ray2.40A/B/C/D/E/F1-112[»]
3X3UX-ray2.09A/B/C/D/E/F1-112[»]
4Y65X-ray1.70A/B/C1-112[»]
4Y6IX-ray1.70A/B/C/D/E/F5-112[»]
ProteinModelPortaliP69488
SMRiP69488
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69488

Family & Domainsi

Sequence similaritiesi

Belongs to the CutA family.Curated

Phylogenomic databases

eggNOGiENOG4105VF7 Bacteria
COG1324 LUCA
HOGENOMiHOG000222826
InParanoidiP69488
KOiK03926
OMAiSVYRWQG
PhylomeDBiP69488

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_01160 CutA, 1 hit
InterProiView protein in InterPro
IPR023700 CutA_Enterobact
IPR004323 Ion_tolerance_CutA
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR23419 PTHR23419, 1 hit
PfamiView protein in Pfam
PF03091 CutA1, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit

Sequencei

Sequence statusi: Complete.

P69488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDEKSSNTA SVVVLCTAPD EATAQDLAAK VLAEKLAACA TLIPGATSLY
60 70 80 90 100
YWEGKLEQEY EVQMILKTTV SHQQALLECL KSHHPYQTPE LLVLPVTHGD
110
TDYLSWLNAS LR
Length:112
Mass (Da):12,331
Last modified:March 15, 2005 - v1
Checksum:i802145EF012DDB69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → R (PubMed:7623667).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77707 Genomic DNA Translation: CAA54780.1
Z36905 Genomic DNA Translation: CAA85374.1
U14003 Genomic DNA Translation: AAA97036.1
U00096 Genomic DNA Translation: AAC77097.1
AP009048 Genomic DNA Translation: BAE78139.1
PIRiI41027
RefSeqiNP_418560.1, NC_000913.3
WP_000883400.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77097; AAC77097; b4137
BAE78139; BAE78139; BAE78139
GeneIDi948660
KEGGiecj:JW4097
eco:b4137
PATRICifig|1411691.4.peg.2563

Similar proteinsi

Entry informationi

Entry nameiCUTA_ECOLI
AccessioniPrimary (citable) accession number: P69488
Secondary accession number(s): P36654, Q2M6G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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