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P69485

- VP2_CAVCI

UniProt

P69485 - VP2_CAVCI

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Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate USA CIA-1) (CAV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:VP2
OrganismiChicken anemia virus (isolate USA CIA-1) (CAV)
Taxonomic identifieri73478 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008444: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000223005Add
BLAST

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

Keywords - Developmental stagei

Early protein

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus protein VP2 family.Curated

Family and domain databases

InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamiPF02957. TT_ORF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING
60 70 80 90 100
VQATNKFTAV GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF
110 120 130 140 150
RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR
160 170 180 190 200
KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD
210
ELLGRPFTTP APVRIV
Length:216
Mass (Da):24,139
Last modified:March 15, 2005 - v1
Checksum:iF82B69EF88BDDE52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14767 Genomic DNA. Translation: AAD09422.1.
PIRiA39926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14767 Genomic DNA. Translation: AAD09422.1 .
PIRi A39926.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view ]
Pfami PF02957. TT_ORF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A hypervariable region in VP1 of chicken infectious anemia virus mediates rate of spread and cell tropism in tissue culture."
    Renshaw R.W., Soine C., Weinkle T., O'Connell P.H., Ohashi K., Watson S., Lucio B., Harrington S., Schat K.A.
    J. Virol. 70:8872-8878(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Renshaw R.W.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 24.

Entry informationi

Entry nameiVP2_CAVCI
AccessioniPrimary (citable) accession number: P69485
Secondary accession number(s): P54091, Q99151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3