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P69485

- VP2_CAVCI

UniProt

P69485 - VP2_CAVCI

Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate USA CIA-1) (CAV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:VP2
    OrganismiChicken anemia virus (isolate USA CIA-1) (CAV)
    Taxonomic identifieri73478 [NCBI]
    Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000008444: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000223005Add
    BLAST

    Expressioni

    Inductioni

    VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

    Keywords - Developmental stagei

    Early protein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gyrovirus protein VP2 family.Curated

    Family and domain databases

    InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view]
    PfamiPF02957. TT_ORF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P69485-1 [UniParc]FASTAAdd to Basket

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    MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING    50
    VQATNKFTAV GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF 100
    RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR 150
    KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD 200
    ELLGRPFTTP APVRIV 216
    Length:216
    Mass (Da):24,139
    Last modified:March 15, 2005 - v1
    Checksum:iF82B69EF88BDDE52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14767 Genomic DNA. Translation: AAD09422.1.
    PIRiA39926.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14767 Genomic DNA. Translation: AAD09422.1 .
    PIRi A39926.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view ]
    Pfami PF02957. TT_ORF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A hypervariable region in VP1 of chicken infectious anemia virus mediates rate of spread and cell tropism in tissue culture."
      Renshaw R.W., Soine C., Weinkle T., O'Connell P.H., Ohashi K., Watson S., Lucio B., Harrington S., Schat K.A.
      J. Virol. 70:8872-8878(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Renshaw R.W.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 24.

    Entry informationi

    Entry nameiVP2_CAVCI
    AccessioniPrimary (citable) accession number: P69485
    Secondary accession number(s): P54091, Q99151
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3