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P69484 (VP2_CAVC1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase VP2

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:VP2
OrganismChicken anemia virus (isolate Germany Cuxhaven-1) (CAV) [Reference proteome]
Taxonomic identifier73475 [NCBI]
Taxonomic lineageVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication. Ref.4

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Induction

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours. Ref.3

Sequence similarities

Belongs to the gyrovirus protein VP2 family.

Ontologies

Keywords
   Developmental stageEarly protein
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Dual specificity protein phosphatase VP2
PRO_0000223004

Sites

Active site951Phosphocysteine intermediate By similarity

Experimental info

Sequence conflict1531V → A in AAA91822. Ref.1
Sequence conflict1871D → N in AAA42882. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P69484 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: F82B69EF88BDDE52

FASTA21624,139
        10         20         30         40         50         60 
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING VQATNKFTAV 

        70         80         90        100        110        120 
GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF RKHWFQECAG LEDRSTQASL 

       130        140        150        160        170        180 
EEAILRPLRV QGKRAKRKLD YHYSQPTPNR KKVYKTVRWQ DELADREADF TPSEEDGGTT 

       190        200        210 
SSDFDEDINF DIGGDSGIVD ELLGRPFTTP APVRIV 

« Hide

References

[1]"Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle."
Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C., Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A., Koch G., van Ormondt H., van der Eb A.J.
J. Virol. 65:3131-3139(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments."
Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S.
Arch. Virol. 124:301-319(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of a 24 kDa protein expressed by chicken anaemia virus."
Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L.
J. Gen. Virol. 76:1557-1562(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[4]"Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope."
Noteborn M.H., Verschueren C.A., Koch G., Van der Eb A.J.
J. Gen. Virol. 79:3073-3077(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55918 Genomic DNA. Translation: AAA91822.1.
M81223 Genomic DNA. Translation: AAA42882.1.
PIRA39926.
A48343.
RefSeqNP_056773.1. NC_001427.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1494446.

Family and domain databases

InterProIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamPF02957. TT_ORF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP2_CAVC1
AccessionPrimary (citable) accession number: P69484
Secondary accession number(s): P54091, Q99151
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families