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P69484

- VP2_CAVC1

UniProt

P69484 - VP2_CAVC1

Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:VP2
    OrganismiChicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
    Taxonomic identifieri73475 [NCBI]
    Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000007528: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000223004Add
    BLAST

    Expressioni

    Inductioni

    VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.1 Publication

    Keywords - Developmental stagei

    Early protein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gyrovirus protein VP2 family.Curated

    Family and domain databases

    InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view]
    PfamiPF02957. TT_ORF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P69484-1 [UniParc]FASTAAdd to Basket

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    MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING    50
    VQATNKFTAV GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF 100
    RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR 150
    KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD 200
    ELLGRPFTTP APVRIV 216
    Length:216
    Mass (Da):24,139
    Last modified:March 15, 2005 - v1
    Checksum:iF82B69EF88BDDE52
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531V → A in AAA91822. (PubMed:1851873)Curated
    Sequence conflicti187 – 1871D → N in AAA42882. (PubMed:1605740)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55918 Genomic DNA. Translation: AAA91822.1.
    M81223 Genomic DNA. Translation: AAA42882.1.
    PIRiA39926.
    A48343.
    RefSeqiNP_056773.1. NC_001427.1.

    Genome annotation databases

    GeneIDi1494446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55918 Genomic DNA. Translation: AAA91822.1 .
    M81223 Genomic DNA. Translation: AAA42882.1 .
    PIRi A39926.
    A48343.
    RefSeqi NP_056773.1. NC_001427.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1494446.

    Family and domain databases

    InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view ]
    Pfami PF02957. TT_ORF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle."
      Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C., Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A., Koch G., van Ormondt H., van der Eb A.J.
      J. Virol. 65:3131-3139(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments."
      Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S.
      Arch. Virol. 124:301-319(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Identification of a 24 kDa protein expressed by chicken anaemia virus."
      Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L.
      J. Gen. Virol. 76:1557-1562(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. "Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope."
      Noteborn M.H., Verschueren C.A., Koch G., Van der Eb A.J.
      J. Gen. Virol. 79:3073-3077(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiVP2_CAVC1
    AccessioniPrimary (citable) accession number: P69484
    Secondary accession number(s): P54091, Q99151
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3