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P69484

- VP2_CAVC1

UniProt

P69484 - VP2_CAVC1

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Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:VP2
OrganismiChicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Taxonomic identifieri73475 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000007528: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000223004Add
BLAST

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.1 Publication

Keywords - Developmental stagei

Early protein

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus protein VP2 family.Curated

Family and domain databases

InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamiPF02957. TT_ORF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69484-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING
60 70 80 90 100
VQATNKFTAV GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF
110 120 130 140 150
RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR
160 170 180 190 200
KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD
210
ELLGRPFTTP APVRIV
Length:216
Mass (Da):24,139
Last modified:March 15, 2005 - v1
Checksum:iF82B69EF88BDDE52
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531V → A in AAA91822. (PubMed:1851873)Curated
Sequence conflicti187 – 1871D → N in AAA42882. (PubMed:1605740)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55918 Genomic DNA. Translation: AAA91822.1.
M81223 Genomic DNA. Translation: AAA42882.1.
PIRiA39926.
A48343.
RefSeqiNP_056773.1. NC_001427.1.

Genome annotation databases

GeneIDi1494446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55918 Genomic DNA. Translation: AAA91822.1 .
M81223 Genomic DNA. Translation: AAA42882.1 .
PIRi A39926.
A48343.
RefSeqi NP_056773.1. NC_001427.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1494446.

Family and domain databases

InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view ]
Pfami PF02957. TT_ORF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle."
    Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C., Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A., Koch G., van Ormondt H., van der Eb A.J.
    J. Virol. 65:3131-3139(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments."
    Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S.
    Arch. Virol. 124:301-319(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of a 24 kDa protein expressed by chicken anaemia virus."
    Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L.
    J. Gen. Virol. 76:1557-1562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope."
    Noteborn M.H., Verschueren C.A., Koch G., Van der Eb A.J.
    J. Gen. Virol. 79:3073-3077(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVP2_CAVC1
AccessioniPrimary (citable) accession number: P69484
Secondary accession number(s): P54091, Q99151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3