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P69483

- VP6_ROTHG

UniProt

P69483 - VP6_ROTHG

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Protein
Intermediate capsid protein VP6
Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Preston/1992) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus C (isolate Human/United Kingdom/Preston/1992) (RV-C)
Taxonomic identifieri31568 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Reviewed prediction.

GO - Cellular componenti

  1. viral envelope Source: InterPro
  2. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Intermediate capsid protein VP6
PRO_0000149571Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity. Interacts with VP2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP69483.

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.

Family and domain databases

InterProiIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

P69483-1 [UniParc]FASTAAdd to Basket

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MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG    50
IGTQPQKEWN FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI 100
VREASRNGMQ PQSPALILLS SSKFKTINFN NSSQSIKNWN AQSRRENPVY 150
EYKNPMLFEY KNSYILQRAN PQFGSVMGLR YYTTSNTCQI AAFDSTLAEN 200
APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD PNNQTTWLFN 250
PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT 300
QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR 350
DSAMPAGTVF QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM 395
Length:395
Mass (Da):44,720
Last modified:March 15, 2005 - v1
Checksum:iBD1CF809C0D5E269
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94156 Genomic RNA. Translation: AAA47340.1.
PIRiA41041. VPXRCR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94156 Genomic RNA. Translation: AAA47340.1 .
PIRi A41041. VPXRCR.

3D structure databases

ProteinModelPortali P69483.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view ]
Pfami PF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view ]
ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K."
    Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R.
    Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP6_ROTHG
AccessioniPrimary (citable) accession number: P69483
Secondary accession number(s): P30213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: December 11, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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