P69482 (VP6_ROTHF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Intermediate capsid protein VP6
Organism	Rotavirus C (isolate Human/Brazil/Belem/1992) (RV-C)
Taxonomic identifier	31566 [NCBI]
Taxonomic lineage	Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › Rotavirus C › Human rotavirus C
Virus host	Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.
Subunit structure	Homotrimer By similarity. Interacts with VP2 By similarity.
Subcellular location	Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.
Sequence similarities	Belongs to the rotavirus VP6 family.

Ontologies

Keywords
Cellular component	Virion
Molecular function	Capsid protein
Gene Ontology (GO)
Biological_process	viral entry into host cell via membrane fusion with the plasma membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Intermediate capsid protein VP6		PRO_0000149570

Sequences

	Sequence		Length	Mass (Da)
	P69482 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: BD1CF809C0D5E269	FASTA	395	44,720
	10 20 30 40 50 60 MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG IGTQPQKEWN 70 80 90 100 110 120 FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI VREASRNGMQ PQSPALILLS 130 140 150 160 170 180 SSKFKTINFN NSSQSIKNWN AQSRRENPVY EYKNPMLFEY KNSYILQRAN PQFGSVMGLR 190 200 210 220 230 240 YYTTSNTCQI AAFDSTLAEN APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD 250 260 270 280 290 300 PNNQTTWLFN PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT 310 320 330 340 350 360 QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR DSAMPAGTVF 370 380 390 QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM

References

[1]

"The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K." Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R. Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94155 Genomic RNA. Translation: AAA47339.1.
PIR	VPXRCR. A41041.
3D structure databases
ProteinModelPortal	P69482.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008980. Capsid_hemagglutn. IPR001385. Rotavirus_A/C_VP6. IPR008935. Virus_capsid_a-hlx_vir. [Graphical view]
Pfam	PF00980. Rota_Capsid_VP6. 1 hit. [Graphical view]
ProDom	PD001812. Rota_Capsid_VP6. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF48345. Capsid_alpha. 1 hit. SSF49818. Capsid_hemag. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VP6_ROTHF

Accession

Primary (citable) accession number: P69482
Secondary accession number(s): P30213

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program