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P69482

- VP6_ROTHF

UniProt

P69482 - VP6_ROTHF

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus C (isolate Human/Brazil/Belem/1992) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus C (isolate Human/Brazil/Belem/1992) (RV-C)
    Taxonomic identifieri31566 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral envelope Source: InterPro
    2. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Intermediate capsid protein VP6PRO_0000149570Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP69482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view]
    PfamiPF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view]
    ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P69482-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG    50
    IGTQPQKEWN FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI 100
    VREASRNGMQ PQSPALILLS SSKFKTINFN NSSQSIKNWN AQSRRENPVY 150
    EYKNPMLFEY KNSYILQRAN PQFGSVMGLR YYTTSNTCQI AAFDSTLAEN 200
    APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD PNNQTTWLFN 250
    PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT 300
    QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR 350
    DSAMPAGTVF QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM 395
    Length:395
    Mass (Da):44,720
    Last modified:March 15, 2005 - v1
    Checksum:iBD1CF809C0D5E269
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94155 Genomic RNA. Translation: AAA47339.1.
    PIRiA41041. VPXRCR.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94155 Genomic RNA. Translation: AAA47339.1 .
    PIRi A41041. VPXRCR.

    3D structure databases

    ProteinModelPortali P69482.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view ]
    Pfami PF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view ]
    ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K."
      Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R.
      Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP6_ROTHF
    AccessioniPrimary (citable) accession number: P69482
    Secondary accession number(s): P30213
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3