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P69481 (VP6_ROTHC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intermediate capsid protein VP6
OrganismRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C) [Reference proteome]
Taxonomic identifier31567 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Subunit structure

Homotrimer By similarity. Interacts with VP2 By similarity.

Subcellular location

Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.

Sequence similarities

Belongs to the rotavirus VP6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Intermediate capsid protein VP6
PRO_0000149569

Sequences

Sequence LengthMass (Da)Tools
P69481 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: BD1CF809C0D5E269

FASTA39544,720
        10         20         30         40         50         60 
MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG IGTQPQKEWN 

        70         80         90        100        110        120 
FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI VREASRNGMQ PQSPALILLS 

       130        140        150        160        170        180 
SSKFKTINFN NSSQSIKNWN AQSRRENPVY EYKNPMLFEY KNSYILQRAN PQFGSVMGLR 

       190        200        210        220        230        240 
YYTTSNTCQI AAFDSTLAEN APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD 

       250        260        270        280        290        300 
PNNQTTWLFN PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT 

       310        320        330        340        350        360 
QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR DSAMPAGTVF 

       370        380        390 
QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM 

« Hide

References

[1]"Molecular cloning, sequence analysis and coding assignment of the major inner capsid protein gene of human group C rotavirus."
Cooke S.J., Lambden P.R., Caul E.O., Clarke I.N.
Virology 184:781-785(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59843 mRNA. Translation: CAA42504.1.
PIRVPXRCR. A41041.
RefSeqYP_392512.1. NC_007570.1.

3D structure databases

ProteinModelPortalP69481.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3773139.

Family and domain databases

InterProIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP6_ROTHC
AccessionPrimary (citable) accession number: P69481
Secondary accession number(s): P30213
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: December 11, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families