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P69481

- VP6_ROTHC

UniProt

P69481 - VP6_ROTHC

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Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).Curated

GO - Cellular componenti

  1. viral envelope Source: InterPro
  2. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Intermediate capsid protein VP6PRO_0000149569Add
BLAST

Interactioni

Subunit structurei

Homotrimer. Interacts with VP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliP69481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.Curated

Family and domain databases

InterProiIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

P69481-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLFSIAKT VSDLKKKVVV GTIYTNVEDV VQQTNELIRT LNGNIFHTGG
60 70 80 90 100
IGTQPQKEWN FQLPQLGTTL LNLDDNYVQS TRGIIDFLSS FIEAVCDDEI
110 120 130 140 150
VREASRNGMQ PQSPALILLS SSKFKTINFN NSSQSIKNWN AQSRRENPVY
160 170 180 190 200
EYKNPMLFEY KNSYILQRAN PQFGSVMGLR YYTTSNTCQI AAFDSTLAEN
210 220 230 240 250
APNNTQRFVY NGRLKRPISN VLMKIEAGAP NISNPTILPD PNNQTTWLFN
260 270 280 290 300
PVQLMNGTFT IEFYNNGQLI DMVRNMGIVT VRTFDSYRIT IDMIRPAAMT
310 320 330 340 350
QYVQRIFPQG GPYHFQATYM LTLSILDATT ESVLCDSHSV EYSIVANVRR
360 370 380 390
DSAMPAGTVF QPGFPWEHTL SNYTVAQEDN LERLLLIASV KRMVM
Length:395
Mass (Da):44,720
Last modified:March 15, 2005 - v1
Checksum:iBD1CF809C0D5E269
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59843 mRNA. Translation: CAA42504.1.
PIRiA41041. VPXRCR.
RefSeqiYP_392512.1. NC_007570.1.

Genome annotation databases

GeneIDi3773139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59843 mRNA. Translation: CAA42504.1 .
PIRi A41041. VPXRCR.
RefSeqi YP_392512.1. NC_007570.1.

3D structure databases

ProteinModelPortali P69481.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773139.

Family and domain databases

InterProi IPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view ]
Pfami PF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view ]
ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, sequence analysis and coding assignment of the major inner capsid protein gene of human group C rotavirus."
    Cooke S.J., Lambden P.R., Caul E.O., Clarke I.N.
    Virology 184:781-785(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP6_ROTHC
AccessioniPrimary (citable) accession number: P69481
Secondary accession number(s): P30213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3