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Protein

Carbohydrate sulfotransferase 11

Gene

Chst11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 130PAPSBy similarity7
Nucleotide bindingi186 – 194PAPSBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-RNO-2022870 Chondroitin sulfate biosynthesis
SABIO-RKiP69478

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 11 (EC:2.8.2.5)
Alternative name(s):
Chondroitin 4-O-sulfotransferase 1
Chondroitin 4-sulfotransferase 1
Short name:
C4S-1
Short name:
C4ST-1
Short name:
C4ST1
Gene namesi
Name:Chst11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1308400 Chst11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini38 – 352LumenalSequence analysisAdd BLAST315

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896661 – 352Carbohydrate sulfotransferase 11Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineBy similarity1

Post-translational modificationi

N-glycosylated; required for activity and stability.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP69478
PRIDEiP69478

Expressioni

Gene expression databases

BgeeiENSRNOG00000008885
ExpressionAtlasiP69478 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012017

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4651 Eukaryota
ENOG4111GJR LUCA
GeneTreeiENSGT00760000119214
HOGENOMiHOG000231801
HOVERGENiHBG050952
InParanoidiP69478
KOiK01017
OMAiPLNEHWQ
OrthoDBiEOG091G0FZO
PhylomeDBiP69478
TreeFamiTF325581

Family and domain databases

InterProiView protein in InterPro
IPR018011 Carb_sulfotrans_8-10
IPR005331 Sulfotransferase
PANTHERiPTHR12137 PTHR12137, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit

Sequencei

Sequence statusi: Complete.

P69478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPALLEVMR MNRICRMVLA TCLGSFILVI FYFQSMLHPV MRRNPFGVDI
60 70 80 90 100
CCRKGSRSPL QELYNPIQLE LSNTAILHQM RRDQVTDTCR ANSAMSRKRR
110 120 130 140 150
VLTPNDLKHL VVDEDHELIY CYVPKVACTN WKRLMMVLSG RGKYSDPMEI
160 170 180 190 200
PANEAHVSAN LKTLNQYSIP EINHRLKSYM KFLFVREPFE RLVSAYRNKF
210 220 230 240 250
TQKYNTSFHK RYGTKIIRRQ RKNATQEALR KGDDVKFEEF VAYLIDPHTQ
260 270 280 290 300
REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL RLAGVSGYLK
310 320 330 340 350
FPTYAKSTRT TDEMTTEFFQ NISAEHQTQL YEVYKLDFLM FNYSVPNYLK

LD
Length:352
Mass (Da):41,626
Last modified:March 15, 2005 - v1
Checksum:i3A693D10430A2EA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277G → Q AA sequence (PubMed:10722746).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03057909 Genomic DNA No translation available.
AABR03059893 Genomic DNA No translation available.
AABR03062052 Genomic DNA No translation available.
AABR03060128 Genomic DNA No translation available.
AABR03059314 Genomic DNA No translation available.
AABR03058261 Genomic DNA No translation available.
AABR03058513 Genomic DNA No translation available.
AABR03056595 Genomic DNA No translation available.
AABR03057359 Genomic DNA No translation available.
AABR03058222 Genomic DNA No translation available.
AABR03059499 Genomic DNA No translation available.
AABR03058053 Genomic DNA No translation available.
AABR03058580 Genomic DNA No translation available.
AABR03056571 Genomic DNA No translation available.
AABR03061700 Genomic DNA No translation available.
AABR03056958 Genomic DNA No translation available.
RefSeqiNP_001101549.1, NM_001108079.1
XP_017450314.1, XM_017594825.1
UniGeneiRn.105288

Genome annotation databases

EnsembliENSRNOT00000012017; ENSRNOP00000012017; ENSRNOG00000008885
GeneIDi314694
KEGGirno:314694
UCSCiRGD:1308400 rat

Similar proteinsi

Entry informationi

Entry nameiCHSTB_RAT
AccessioniPrimary (citable) accession number: P69478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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