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Protein

Probable Vpr-like protein

Gene
N/A
Organism
Feline immunodeficiency virus (strain San Diego) (FIV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Seems to function as a Vpr-like protein, since it mediates host cell cycle arrest in G2 phase. Cell cycle arrest creates a favorable environment for maximizing viral expression and production.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Vpr-like protein
Alternative name(s):
ORF2
OrfA
Protein Tat
OrganismiFeline immunodeficiency virus (strain San Diego) (FIV)
Taxonomic identifieri11675 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusFeline lentivirus group
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

  • Virion Curated
  • Host nucleus 1 Publication

  • Note: Contains both nuclear import and nuclear export signals.

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000855121 – 77Probable Vpr-like proteinAdd BLAST77

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Nuclear export signal9
Motifi44 – 53Nuclear localization signal1 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 61Cys-rich7

Sequencei

Sequence statusi: Complete.

P69469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVIRIFNKV AERLDKEAAI RIFVLAHQLE RDKLIRLLQG LLWRLRFRKP
60 70
KSKDCLCWFC CRLYYWQLQS TLSIDTA
Length:77
Mass (Da):9,371
Last modified:March 15, 2005 - v1
Checksum:i22FF023E0FC9792D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36968 Genomic RNA. Translation: AAA43078.1.
S42322 mRNA. Translation: AAB22931.1.
PIRiA42748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36968 Genomic RNA. Translation: AAA43078.1.
S42322 mRNA. Translation: AAB22931.1.
PIRiA42748.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiVPRL_FIVSD
AccessioniPrimary (citable) accession number: P69469
Secondary accession number(s): P19033, P69468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Was first thought to be the equivalent of lentiviral Tat protein.Curated
PubMed:1323707 sequence does not seem to originate from isolate Petaluma as described, but rather from the strain San Diego.Curated

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.