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Protein

Sec-independent protein translocase protein TatB

Gene

tatB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.UniRule annotation5 Publications

GO - Molecular functioni

  • identical protein binding Source: EcoCyc
  • proton motive force dependent protein transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • intracellular protein transmembrane transport Source: EcoCyc
  • protein secretion Source: InterPro
  • protein transport by the Tat complex Source: EcoCyc

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7808-MONOMER
MetaCyc:G7808-MONOMER

Protein family/group databases

TCDBi2.A.64.1.1 the twin arginine targeting (tat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatBUniRule annotation
Gene namesi
Name:tatBUniRule annotation
Synonyms:mttA2, ysgB
Ordered Locus Names:b3838, JW5580
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14322 tatB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • intracellular Source: GOC
  • TAT protein transport complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption blocks the export of seven endogenous Tat substrates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926531 – 171Sec-independent protein translocase protein TatBAdd BLAST171

Proteomic databases

PaxDbiP69425
PRIDEiP69425

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. A complex containing only TatA and TatB has also been identified. It could be either an assembly intermediate or a disassembly intermediate generated during translocation activity. Each of TatA, TatB and TatC are able to interact in pairs without the third partner; TatB also forms homooligomers. Interacts with the signal sequence of DmsA and DmsD.UniRule annotation7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262617, 402 interactors
DIPiDIP-58536N
IntActiP69425, 6 interactors
MINTiP69425
STRINGi316385.ECDH10B_4028

Structurei

3D structure databases

ProteinModelPortaliP69425
SMRiP69425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The membrane-extrinsic domain forms parallel contacts with at least one other TatB protein.1 Publication

Sequence similaritiesi

Belongs to the TatB family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105X8U Bacteria
COG1826 LUCA
HOGENOMiHOG000245368
InParanoidiP69425
KOiK03117
OMAiGQFQEAM

Family and domain databases

HAMAPiMF_00237 TatB, 1 hit
InterProiView protein in InterPro
IPR018448 TatB
IPR003998 TatB-like
PRINTSiPR01506 TATBPROTEIN
TIGRFAMsiTIGR01410 tatB, 1 hit

Sequencei

Sequence statusi: Complete.

P69425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIGFSELL LVFIIGLVVL GPQRLPVAVK TVAGWIRALR SLATTVQNEL
60 70 80 90 100
TQELKLQEFQ DSLKKVEKAS LTNLTPELKA SMDELRQAAE SMKRSYVAND
110 120 130 140 150
PEKASDEAHT IHNPVVKDNE AAHEGVTPAA AQTQASSPEQ KPETTPEPVV
160 170
KPAADAEPKT AAPSPSSSDK P
Length:171
Mass (Da):18,421
Last modified:March 1, 2005 - v1
Checksum:i31F1405404F5DABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005830 Genomic DNA Translation: CAA06725.1
AF067848 Genomic DNA Translation: AAC19241.1
M87049 Genomic DNA Translation: AAA67633.1 Sequence problems.
U00096 Genomic DNA Translation: AAT48228.1
AP009048 Genomic DNA Translation: BAE77464.1
PIRiG91224
RefSeqiWP_000459594.1, NZ_LN832404.1
YP_026270.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48228; AAT48228; b3838
BAE77464; BAE77464; BAE77464
GeneIDi948319
KEGGiecj:JW5580
eco:b3838
PATRICifig|1411691.4.peg.2871

Similar proteinsi

Entry informationi

Entry nameiTATB_ECOLI
AccessioniPrimary (citable) accession number: P69425
Secondary accession number(s): O69415
, O87926, P27856, Q2M8E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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